c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling (Q28504741)

24 January 2017

title

c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling (English)

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24 January 2017

main subject

Rous sarcoma oncogene

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GOA release 2020-03-11

Harold Kim

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24 January 2017

Mike Laing

series ordinal

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24 January 2017

William Muller

series ordinal

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24 January 2017

language of work or name

English

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publication date

25 August 2005

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24 January 2017

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24 January 2017

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24 January 2017

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24 January 2017

page(s)

5629–5636

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Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance

24 January 2017

cites work

1 reference

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PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

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Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation

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CDK-independent activation of estrogen receptor by cyclin D1

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Estradiol-binding mechanism and binding capacity of the human estrogen receptor is regulated by tyrosine phosphorylation.

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Phosphorylation of tyrosine 537 on the human estrogen receptor is required for binding to an estrogen response element

21 January 2018

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Non-transcriptional action of oestradiol and progestin triggers DNA synthesis.

21 January 2018

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Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit

21 January 2018

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Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinants

21 January 2018

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Distinct Tyrosine Autophosphorylation Sites Negatively and Positively Modulate Neu-Mediated Transformation

21 January 2018

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Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

21 January 2018

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c-erbB2 expression predicts tamoxifen efficacy in breast cancer patients

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Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activation.

21 January 2018

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A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

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c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes

21 January 2018

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Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells

21 January 2018

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Overexpression of c-erbB2 is an independent marker of resistance to endocrine therapy in advanced breast cancer

21 January 2018

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Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

21 January 2018

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ErbB2 is required for ductal morphogenesis of the mammary gland

21 January 2018

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Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase

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c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

21 January 2018

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Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

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Insights from the study of animals lacking functional estrogen receptor

21 January 2018

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Identification of phosphorylation sites in the mouse oestrogen receptor

21 January 2018

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The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation

21 January 2018

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Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene

21 January 2018

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Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor

21 January 2018

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Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells

21 January 2018

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Proteasome-dependent degradation of the human estrogen receptor

21 January 2018

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Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer

21 January 2018

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c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry

21 January 2018

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Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2.

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Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling

21 January 2018

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Cyclin D1 provides a link between development and oncogenesis in the retina and breast

21 January 2018

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Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

21 January 2018

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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

21 January 2018

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Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

21 January 2018

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A beta-catenin survival signal is required for normal lobular development in the mammary gland.

21 January 2018

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Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene

21 January 2018

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Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine

21 January 2018

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Function of estrogen receptor tyrosine 537 in hormone binding, DNA binding, and transactivation.

21 January 2018

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Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1

21 January 2018

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Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

c-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208718

inferred from DOI database lookup

7 January 2021

based on heuristic

Bidirectional interactions between the estrogen receptor and the cerbB-2 signaling pathways: heregulin inhibits estrogenic effects in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208718

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1208718

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Dimensions Publication ID

1003698243

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1 reference