Influence of various polymorphic variants of cytochrome P450 oxidoreductase (POR) on drug metabolic activity of CYP3A4 and CYP2B6 (Q28484196)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22719896%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Influence of various polymorphic variants of cytochrome P450 oxidoreductase (POR) on drug metabolic activity of CYP3A4 and CYP2B6 (English)

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5 February 2020

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5 February 2020

Xuan Chen

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5 February 2020

Li Qiang Pan

series ordinal

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5 February 2020

Su Zeng

series ordinal

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5 February 2020

Shu Qing Chen

series ordinal

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5 February 2020

language of work or name

English

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publication date

12 June 2012

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5 February 2020

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5 February 2020

volume

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issue

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5 February 2020

page(s)

e38495

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Creative Commons Attribution 4.0 International

5 February 2020

start time

12 June 2012

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro

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Reduction in hepatic drug metabolizing CYP3A4 activities caused by P450 oxidoreductase mutations identified in patients with disordered steroid metabolism

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Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase

19 March 2017

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Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

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Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase

19 March 2017

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Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis

19 March 2017

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Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study

19 March 2017

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Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome

19 March 2017

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Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

19 March 2017

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Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase

19 March 2017

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Engineering of proteolytically stable NADPH-cytochrome P450 reductase

19 March 2017

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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

19 March 2017

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Altered human CYP3A4 activity caused by Antley-Bixler syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro system

7 April 2017

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Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase c

29 September 2017

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Identification of Cytochrome P450 Oxidoreductase Gene Variants That Are Significantly Associated with the Interindividual Variations in Warfarin Maintenance Dose

29 September 2017

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Consequences of POR mutations and polymorphisms.

29 September 2017

1 reference

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Human cytochrome P450 oxidoreductase deficiency caused by the Y181D mutation: molecular consequences and rescue of defect.

29 September 2017

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Nomenclature for alleles of the cytochrome P450 oxidoreductase gene

29 September 2017

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Genetic variation in human P450 oxidoreductase.

29 September 2017

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Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4.

29 September 2017

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Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations

29 September 2017

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Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects

29 September 2017

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Clinical, structural and functional implications of mutations and polymorphisms in human NADPH P450 oxidoreductase

29 September 2017

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Pharmacogenomics and individualized drug therapy

29 September 2017

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Pharmacogenetics - five decades of therapeutic lessons from genetic diversity

29 September 2017

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Cytochrome P450: what have we learned and what are the future issues?

29 September 2017

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Rapid titer determination of baculovirus by quantitative real-time polymerase chain reaction

29 September 2017

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Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis

29 September 2017

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Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

29 September 2017

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Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.

29 September 2017

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29 September 2017

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The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test

2 June 2018

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Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase.

21 January 2018

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Genetic variation of human cytochrome p450 reductase as a potential biomarker for mitomycin C-induced cytotoxicity

21 January 2018

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Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase

21 January 2018

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Diminished FAD binding in the Y459H and V492E Antley-Bixler syndrome mutants of human cytochrome P450 reductase

21 January 2018

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Pharmacogenetics of P450 oxidoreductase: effect of sequence variants on activities of CYP1A2 and CYP2C19.

21 January 2018

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Effect of genetic variation on human cytochrome p450 reductase-mediated paraquat cytotoxicity

21 January 2018

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Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method

21 January 2018

1 reference

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The role of a conserved serine residue within hydrogen bonding distance of FAD in redox properties and the modulation of catalysis by Ca2+/calmodulin of constitutive nitric-oxide synthases

21 January 2018

1 reference

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Human cytochrome P450 3A4-catalyzed testosterone 6 beta-hydroxylation and erythromycin N-demethylation. Competition during catalysis.

21 January 2018

1 reference

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Evidence for a new physiological role of hepatic NADPH:ferricytochrome (P-450) oxidoreductase. Direct electron input to the microsomal fatty acid chain elongation system

27 November 2018

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12 December 2020

Characterizing the effect of UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A9 genetic polymorphisms on enantioselective glucuronidation of flurbiprofen

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12 December 2020

Structural features of liver microsomal NADPH-cytochrome P-450 reductase. Hydrophobic domain, hydrophilic domain, and connecting region

1 reference

12 December 2020

Differential Inhibition of CYP17A1 and CYP21A2 Activities by the P450 Oxidoreductase Mutant A287P

1 reference

12 December 2020

Novel SNPs in cytochrome P450 oxidoreductase

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12 December 2020

P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0038495

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22719896%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

ADS bibcode

2012PLoSO...738495C

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22719896%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

22719896

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22719896%20AND%20SRC:MED&resulttype=core&format=json