Functional characterization of MODY2 mutations highlights the importance of the fine-tuning of glucokinase and its role in glucose sensing (Q28479050)

19 October 2023

Angel Gutierrez-Nogués

object named as

Angel Gutierrez-Nogués

Angel

Gutierrez-Nogués

1 reference

19 October 2023

Olivier Vincent

Olivier

Vincent

1 reference

19 October 2023

Angel Campos-Barros

Angel

Campos-Barros

1 reference

19 October 2023

Jesús Argente

Jesús

Argente

1 reference

19 October 2023

author name string

Carmen-María García-Herrero

Carmen-María

García-Herrero

1 reference

19 October 2023

Oscar Rubio-Cabezas

Oscar

Rubio-Cabezas

1 reference

19 October 2023

Sharona Azriel

Sharona

Azriel

1 reference

19 October 2023

Angel Aragonés

Angel

Aragonés

1 reference

Creative Commons Attribution 4.0 International

19 October 2023

language of work or name

English

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publication date

2012

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e30518

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start time

24 January 2012

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April 2022 Public Data File from Crossref

copyrighted

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cites work

Molecular physiology of mammalian glucokinase

1 reference

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Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Differences in regulatory properties between human and rat glucokinase regulatory protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

The determination of enzyme inhibitor constants

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Research and Development of Glucokinase Activators for Diabetes Therapy: Theoretical and Practical Aspects

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Phenotype variability and neonatal diabetes in a large family with heterozygous mutation of the glucokinase gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Assessing the potential of glucokinase activators in diabetes therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Glucokinase and molecular aspects of liver glycogen metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Effect of mutations on the sensitivity of human beta-cell glucokinase to liver regulatory protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Short-term control of glucokinase activity: role of a regulatory protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Site-directed mutagenesis studies on the determinants of sugar specificity and cooperative behavior of human beta-cell glucokinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Binding of ATP at the active site of human pancreatic glucokinase – nucleotide‐induced conformational changes with possible implications for its kinetic cooperativity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265476

Glucokinase and glucose homeostasis: proven concepts and new ideas

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030518

beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030518

Permanent neonatal diabetes caused by a homozygous nonsense mutation in the glucokinase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030518

Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030518

Identification and characterization of the ATP-binding site in human pancreatic glucokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030518

A novel glucokinase activator modulates pancreatic islet and hepatocyte function

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030518

Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families

21 January 2018

1 reference

12 December 2020

From Clinicogenetic Studies of Maturity-Onset Diabetes of the Young to Unraveling Complex Mechanisms of Glucokinase Regulation

1 reference

12 December 2020

Study of the regulatory properties of glucokinase by site-directed mutagenesis: conversion of glucokinase to an enzyme with high affinity for glucose

1 reference

12 December 2020

An allosteric model for the inhibition of glucokinase by long chain acyl coenzyme A

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0030518

Identifiers

DOI

0 references

ADS bibcode

2012PLoSO...730518G

0 references

Fatcat ID

release_tb42ifxvvnbwzj2n4ankexmo7y

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tb42ifxvvnbwzj2n4ankexmo7y

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3265476

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