Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single Agent (Q28391163)

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English	Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single Agent	scientific article

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instance of

scholarly article

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title

Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single Agent (English)

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main subject

brain

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Soluble epoxide hydrolase

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author

Jeffrey J Iliff

series ordinal

1

object named as

Jeffrey J Iliff

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author name string

Nabil J Alkayed

series ordinal

2

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language of work or name

English

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publication date

1 March 2009

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published in

Future Neurology

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volume

4

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issue

2

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page(s)

179-199

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cites work

Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia

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Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population

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Soluble epoxide hydrolase: a novel therapeutic target in stroke

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Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice

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Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function

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Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study

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Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2

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Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure

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The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity

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Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms

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Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension

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1,026 experimental treatments in acute stroke

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Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation

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P-450 metabolites of arachidonic acid in the control of cardiovascular function

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Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo

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29 September 2017

Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.

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29 September 2017

Distribution and expression of soluble epoxide hydrolase in human brain

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29 September 2017

Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia

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The soluble epoxide hydrolase as a pharmaceutical target for hypertension

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Cytochrome P-450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis factor-alpha via MAPK and PI3K/Akt signaling pathways.

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The inflammatory response in stroke

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Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs).

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Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.

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29 September 2017

Beyond vasodilatation: non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system

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Action of epoxyeicosatrienoic acids on cellular function

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Cardiovascular therapeutic aspects of soluble epoxide hydrolase inhibitors.

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Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia

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Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smoking

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Role of astrocytes in cerebrovascular regulation

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An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats

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29 September 2017

Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis.

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TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels.

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An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension

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The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke

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A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin II-induced renal injury

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Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study

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29 September 2017

Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide

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Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation

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29 September 2017

Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids

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Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition

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Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries.

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Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats

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Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow

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29 September 2017

Genetic and environmental factors that regulate cytosolic epoxide hydrolase activity in normal human lymphocytes

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29 September 2017

Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model

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2 June 2018

Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells.

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2 June 2018

Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans

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2 June 2018

Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction

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2 June 2018

Bioassay of an endothelium-derived hyperpolarizing factor from bovine coronary arteries: role of a cytochrome P450 metabolite

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2 June 2018

Identification of arachidonate P-450 metabolites in human platelet phospholipids

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2 June 2018

Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry

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2 June 2018

Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid

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2 June 2018

Brain synthesis and cerebrovascular action of cytochrome P-450/monooxygenase metabolites of arachidonic acid

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2 June 2018

Brain synthesis and cerebrovascular action of epoxygenase metabolites of arachidonic acid

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2 June 2018

Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle

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2 June 2018

Epoxyeicosatrienoic acids activate K+ channels in coronary smooth muscle through a guanine nucleotide binding protein.

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14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles

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21 January 2018

Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids

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21 January 2018

Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids

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Metabolism of arachidonic acid to epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and prostaglandins in cultured rat hippocampal astrocytes

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21 January 2018

Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Arachidonic acid epoxygenase metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

PPAR-alpha activator fenofibrate increases renal CYP-derived eicosanoid synthesis and improves endothelial dilator function in obese Zucker rats

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Polymorphisms in human soluble epoxide hydrolase.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Hypoxic preconditioning and tolerance via hypoxia inducible factor (HIF) 1alpha-linked induction of P450 2C11 epoxygenase in astrocytes

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Contribution of epoxyeicosatrienoic acids to the hypoxia-induced activation of Ca2+ -activated K+ channel current in cultured rat hippocampal astrocytes

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Involvement of TRP-like channels in the acute ischemic response of hippocampal CA1 neurons in brain slices.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.2217%2F14796708.4.2.179

retrieved

21 January 2018

Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749308

retrieved

27 November 2018

A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749308

retrieved

27 November 2018

Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749308

retrieved

27 November 2018

Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749308

retrieved

27 November 2018

Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749308

retrieved

27 November 2018

14(R),15(S)-epoxyeicosatrienoic acid (14(R),15(S)-EET) receptor in guinea pig mononuclear cell membranes.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749308

retrieved

27 November 2018

Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19779591

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19779591

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19779591

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cytochrome P-450 attenuates hypoxemia of acute lung injury in dogs

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19779591

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19779591

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19779591

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.2217/14796708.4.2.179

0 references

Fatcat ID

release_bif46a25ezbm7i3grqnstvxvuu

0 references

PMC publication ID

2749308

0 references

PubMed publication ID

19779591

0 references

ResearchGate publication ID

26836510

0 references

 

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