Stable expression and functional characterization of a human nicotinic acetylcholine receptor with α6β2 properties: discovery of selective antagonists (Q28388268)

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English	Stable expression and functional characterization of a human nicotinic acetylcholine receptor with α6β2 properties: discovery of selective antagonists	scientific article

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Stable expression and functional characterization of a human nicotinic acetylcholine receptor with α6β2 properties: discovery of selective antagonists (English)

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Anna Maria Capelli

1

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Laura Castelletti

2

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Yu Hua Chen

3

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Harjeet Van der Keyl

4

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Luca Pucci

5

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Beatrice Oliosi

6

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Cristian Salvagno

7

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Barbara Bertani

8

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Cecilia Gotti

9

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Andrew Powell

10

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Manolo Mugnaini

11

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publication date

May 2011

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British Journal of Pharmacology

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163

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2

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313-29

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Discovery of novel alpha7 nicotinic receptor antagonists

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20 March 2017

TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity

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20 March 2017

Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087134

20 March 2017

In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087134

20 March 2017

The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice

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20 March 2017

Brain reward circuitry: insights from unsensed incentives

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20 March 2017

Neuronal nicotinic receptors: from protein structure to function

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20 March 2017

GTS-21, a mixed nicotinic receptor agonist/antagonist, does not affect the nicotine cue

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087134

20 March 2017

A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087134

20 March 2017

"Orphan" alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087134

20 March 2017

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits

1 reference

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20 March 2017

Use of a snake venom toxin to characterize the cholinergic receptor protein

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20 March 2017

Functional characterization of mouse alpha4beta2 nicotinic acetylcholine receptors stably expressed in HEK293T cells

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20 March 2017

Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

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20 March 2017

Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087134

20 March 2017

Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.

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20 March 2017

Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei

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20 March 2017

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

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7 April 2017

Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods

1 reference

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29 September 2017

Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors in the nucleus accumbens shell regulate progressive ratio responding maintained by nicotine

1 reference

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29 September 2017

Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors

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29 September 2017

Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras

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29 September 2017

Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087134

29 September 2017

Up-regulation of nicotinic receptors by nicotine varies with receptor subtype

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087134

29 September 2017

Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087134

29 September 2017

The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum

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29 September 2017

Beta3 subunits promote expression and nicotine-induced up-regulation of human nicotinic alpha6* nicotinic acetylcholine receptors expressed in transfected cell lines

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29 September 2017

Incorporation of the beta3 subunit has a dominant-negative effect on the function of recombinant central-type neuronal nicotinic receptors

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29 September 2017

Brain neuronal nicotinic receptors as new targets for drug discovery

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29 September 2017

Striatal alpha6* nicotinic acetylcholine receptors: potential targets for Parkinson's disease therapy

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29 September 2017

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29 September 2017

Nicotinic Acetylcholine Receptors of Muscles and Nerves

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29 September 2017

Expression and functional characterisation of a human chimeric nicotinic receptor with alpha6beta4 properties

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29 September 2017

Nicotinic acetylcholine receptors as targets for antidepressants.

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29 September 2017

Drugs selective for nicotinic receptor subtypes: a real possibility or a dream?

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29 September 2017

Role of dopamine in the behavioural actions of nicotine related to addiction

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29 September 2017

"Scaffold-Hopping" by Topological Pharmacophore Search: A Contribution to Virtual Screening

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29 September 2017

International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits.

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Mammalian expression of transmembrane receptors for pharmaceutical applications

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29 September 2017

The neuronal alpha6 subunit forms functional heteromeric acetylcholine receptors in human transfected cells

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29 September 2017

Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo

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29 September 2017

Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain

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29 September 2017

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain

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29 September 2017

Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors

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2 June 2018

Methyllycaconitine is a potent antagonist of alpha-conotoxin-MII-sensitive presynaptic nicotinic acetylcholine receptors in rat striatum

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2 June 2018

Allosteric nicotinic receptors, human pathologies.

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2 June 2018

Xenopus Oocytes express a unitary glutamate receptor endogenously

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2 June 2018

Multiple determinants of dihydro-beta-erythroidine sensitivity on rat neuronal nicotinic receptor alpha subunits

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2 June 2018

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

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2 June 2018

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

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2 June 2018

Ligand efficiency indices as guideposts for drug discovery.

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21 January 2018

Antidepressant-like effects of nicotinic acetylcholine receptor antagonists, but not agonists, in the mouse forced swim and mouse tail suspension tests

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21 January 2018

Effect of novel alpha-conotoxins on nicotine-stimulated [3H]dopamine release from rat striatal synaptosomes

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21 January 2018

Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype.

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21 January 2018

High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation

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21 January 2018

Transport of multiple nicotinic acetylcholine receptors in the rat optic nerve: high densities of receptors containing alpha6 and beta3 subunits

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21 January 2018

Heterogeneity and selective targeting of neuronal nicotinic acetylcholine receptor (nAChR) subtypes expressed on retinal afferents of the superior colliculus and lateral geniculate nucleus: identification of a new native nAChR subtype alpha3beta2(al

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21 January 2018

Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation.

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21 January 2018

Nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area alpha6beta2* receptors in mediating systemic nicotine effects on dopamine release, locomotion, and reinforcement.

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21 January 2018

Human alpha6 AChR subtypes: subunit composition, assembly, and pharmacological responses

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21 January 2018

Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors

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21 January 2018

Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience.

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21 January 2018

A comparative study of the effects of the intravenous self-administration or subcutaneous minipump infusion of nicotine on the expression of brain neuronal nicotinic receptor subtypes

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21 January 2018

Involvement of alpha6/alpha3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies: [(125)I]-alpha-conotoxin MII binding in the thalamus and striatum.

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21 January 2018

Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.

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21 January 2018

Pharmacological properties of rat alpha 7 nicotinic receptors expressed in native and recombinant cell systems

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21 January 2018

Guide to Receptors and Channels (GRAC), 4th Edition

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27 November 2018

Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors.

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27 November 2018

Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum.

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27 November 2018

Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha 7/125I-alpha-bungarotoxin receptor subtypes.

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27 November 2018

Similarity Searching Using Reduced Graphs

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12 December 2020

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Differential coupling of alpha7 and non-alpha7 nicotinic acetylcholine receptors to calcium-induced calcium release and voltage-operated calcium channels in PC12 cells

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https://pubmed.ncbi.nlm.nih.gov/21232042

12 December 2020

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[Separation of excitable membranes from the electric organ of Electrophorus electricus]

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https://pubmed.ncbi.nlm.nih.gov/21232042

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10.1111/J.1476-5381.2011.01213.X

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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