Targeting epoxides for organ damage in hypertension (Q28387558)

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English	Targeting epoxides for organ damage in hypertension	scientific article

Statements

instance of

scholarly article

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review article

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stated in

Europe PubMed Central

title

Targeting epoxides for organ damage in hypertension (English)

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main subject

arterial hypertension

1 reference

based on heuristic

inferred from title

author name string

John D Imig

series ordinal

1

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language of work or name

English

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publication date

October 2010

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published in

Journal of Cardiovascular Pharmacology

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volume

56

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issue

4

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page(s)

329-35

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cites work

Soluble epoxide hydrolase inhibition modulates vascular remodeling

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PubMed Central

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Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling

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20 March 2017

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

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PubMed Central

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20 March 2017

Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice

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20 March 2017

Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension

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PubMed Central

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20 March 2017

Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy

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PubMed Central

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20 March 2017

Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia

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PubMed Central

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20 March 2017

Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice

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20 March 2017

Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function

1 reference

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PubMed Central

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20 March 2017

Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function

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PubMed Central

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20 March 2017

Cytochrome P450 2C is an EDHF synthase in coronary arteries

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PubMed Central

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20 March 2017

Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.

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PubMed Central

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20 March 2017

Potentiation of Ca2+ signaling in endothelial cells by 11,12-epoxyeicosatrienoic acid

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20 March 2017

Increased blood pressure in mice lacking cytochrome P450 2J5

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20 March 2017

Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain

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PubMed Central

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20 March 2017

Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation

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PubMed Central

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7 April 2017

Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors

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PubMed Central

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7 April 2017

Soluble epoxide hydrolase is a therapeutic target for acute inflammation

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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7 April 2017

P-450 metabolites of arachidonic acid in the control of cardiovascular function

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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7 April 2017

Epoxyeicosatrienoic acids and endothelium-dependent responses.

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PubMed Central

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29 September 2017

Epoxyeicosatrienoic acid analogs and vascular function

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PubMed Central

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29 September 2017

Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.

1 reference

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PubMed Central

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29 September 2017

14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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29 September 2017

Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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29 September 2017

Soluble epoxide hydrolase, a target with multiple opportunities for cardiovascular drug discovery

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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29 September 2017

The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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29 September 2017

Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection.

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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29 September 2017

Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo

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PubMed Central

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29 September 2017

Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.

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PubMed Central

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29 September 2017

Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats.

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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29 September 2017

Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.

1 reference

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PubMed Central

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29 September 2017

Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels.

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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29 September 2017

Orally bioavailable potent soluble epoxide hydrolase inhibitors

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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29 September 2017

Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension.

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PubMed Central

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29 September 2017

Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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29 September 2017

Epoxyeicosatrienoic acids, cell signaling and angiogenesis

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PubMed Central

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29 September 2017

Antileukotrienes in the treatment of asthma and allergic rhinitis

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PubMed Central

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29 September 2017

Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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29 September 2017

Cardiovascular therapeutic aspects of soluble epoxide hydrolase inhibitors.

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PubMed Central

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29 September 2017

Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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29 September 2017

Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition

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PubMed Central

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29 September 2017

An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension

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PubMed Central

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29 September 2017

Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases

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PubMed Central

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29 September 2017

Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids

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29 September 2017

Coxibs and cardiovascular disease

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29 September 2017

14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries.

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PubMed Central

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29 September 2017

Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels

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PubMed Central

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29 September 2017

Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive rats

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PubMed Central

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29 September 2017

Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids

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29 September 2017

Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation

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PubMed Central

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29 September 2017

Activation of microsomal cytochrome P450 mono-oxygenase by Ca2+ store depletion and its contribution to Ca2+ entry in porcine aortic endothelial cells

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2 June 2018

Actions of epoxygenase metabolites on the preglomerular vasculature.

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2 June 2018

Cytochrome P450 mono-oxygenase-regulated signalling of Ca2+ entry in human and bovine endothelial cells

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PubMed Central

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2 June 2018

Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry

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PubMed Central

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2 June 2018

Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle

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PubMed Central

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2 June 2018

Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids

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PubMed Central

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27 November 2018

Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium.

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PubMed Central

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27 November 2018

Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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27 November 2018

Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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27 November 2018

Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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27 November 2018

Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids

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PubMed Central

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27 November 2018

11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression

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PubMed Central

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27 November 2018

14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries

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PubMed Central

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27 November 2018

11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1.

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PubMed Central

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27 November 2018

Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation

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PubMed Central

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27 November 2018

14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries

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PubMed Central

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27 November 2018

Cytochrome P450 2C9-induced endothelial cell proliferation involves induction of mitogen-activated protein (MAP) kinase phosphatase-1, inhibition of the c-Jun N-terminal kinase, and up-regulation of cyclin D1.

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PubMed Central

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27 November 2018

Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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27 November 2018

Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071608

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27 November 2018

14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles

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PubMed Central

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27 November 2018

Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20531214

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12 December 2020

based on heuristic

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5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20531214

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12 December 2020

based on heuristic

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Afferent arteriolar vasodilation to the sulfonimide analog of 11, 12-epoxyeicosatrienoic acid involves protein kinase A

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20531214

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12 December 2020

based on heuristic

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Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20531214

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12 December 2020

based on heuristic

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Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20531214

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1097/FJC.0B013E3181E96E0C

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PMC publication ID

3071608

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PubMed publication ID

20531214

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ResearchGate publication ID

44656932

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