Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders

12 December 2020

Protective effects of glial cell line-derived neurotrophic factor on hippocampal neurons after traumatic brain injury in rats

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12 December 2020

Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury.

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12 December 2020

Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

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12 December 2020

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

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12 December 2020

Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

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12 December 2020

Calcium-induced actin depolymerization reduces NMDA channel activity

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12 December 2020

Reduced neurotoxicity in transgenic mice overexpressing human copper-zinc-superoxide dismutase

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12 December 2020

NF-kappaB in neuronal plasticity and neurodegenerative disorders

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12 December 2020

Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro

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12 December 2020

Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis

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12 December 2020

Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus

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12 December 2020

Protective Effect of the Energy Precursor Creatine Against Toxicity of Glutamate and β-Amyloid in Rat Hippocampal Neurons

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12 December 2020

Dantrolene is cytoprotective in two models of neuronal cell death

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12 December 2020

Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons.

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12 December 2020

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

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12 December 2020

DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures.

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12 December 2020

Nitric oxide, a novel neuronal messenger

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12 December 2020

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

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12 December 2020

Mitochondrial deenergization underlies neuronal calcium overload following a prolonged glutamate challenge

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12 December 2020

Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture.

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12 December 2020

Group I metabotropic glutamate receptors in spinal cord injury: roles in neuroprotection and the development of chronic central pain

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12 December 2020

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

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12 December 2020

Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

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12 December 2020

Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease

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12 December 2020

Selective vulnerability of spinal cord motor neurons to non-NMDA toxicity

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12 December 2020

Genetic aspects of amyotrophic lateral sclerosis.

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12 December 2020

Free radical pathways in CNS injury

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12 December 2020

Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord

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12 December 2020

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

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12 December 2020

PDGFs protect hippocampal neurons against energy deprivation and oxidative injury: evidence for induction of antioxidant pathways.

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12 December 2020

Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat.

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12 December 2020

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

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12 December 2020

The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity

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12 December 2020

Clinical experiences with nimodipine in cerebral ischemia

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12 December 2020

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.

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12 December 2020

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice

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12 December 2020

Role of glutamate in neurodegeneration of dopamine neurons in several animal models of parkinsonism

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12 December 2020

Glutamate AMPA receptor antagonist treatment for ischaemic stroke

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12 December 2020

Calpain inhibitors prevent nitric oxide-triggered excitotoxic apoptosis

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12 December 2020

Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Astrocytic gap junctional communication decreases neuronal vulnerability to oxidative stress-induced disruption of Ca2+ homeostasis and cell death

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12 December 2020

Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility?

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12 December 2020

Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

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12 December 2020

Delayed treatment with YM90K, an AMPA receptor antagonist, protects against ischaemic damage after middle cerebral artery occlusion in rats

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12 December 2020

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

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12 December 2020

Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease

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12 December 2020

A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion

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12 December 2020

Pretreatment with intraventricular basic fibroblast growth factor decreases infarct size following focal cerebral ischemia in rats

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12 December 2020

K+ channel openers protect hippocampal neurons against oxidative injury and amyloid beta-peptide toxicity

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12 December 2020

Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition

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12 December 2020

Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture

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12 December 2020

A randomized double-blind controlled study of nimodipine in acute cerebral ischemic stroke

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12 December 2020

Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture

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12 December 2020

Endogenous neuroprotection factors and traumatic brain injury: mechanisms of action and implications for therapy

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12 December 2020

Intracerebral injection of caspase-3 inhibitor prevents neuronal apoptosis after kainic acid-evoked status epilepticus

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12 December 2020

On the mechanisms of neuroprotection by creatine and phosphocreatine

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12 December 2020

NMDA Receptor Activation Produces Concurrent Generation of Nitric Oxide and Reactive Oxygen Species: Implications for Cell Death

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12 December 2020

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

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12 December 2020

Experimental models of Parkinson's disease

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12 December 2020

Caspase-mediated degradation of AMPA receptor subunits: a mechanism for preventing excitotoxic necrosis and ensuring apoptosis

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12 December 2020

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis

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12 December 2020

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12 December 2020

Glutamate induced cell death: apoptosis or necrosis?

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12 December 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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12 December 2020

NMDA-dependent superoxide production and neurotoxicity

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12 December 2020

Perforant path stimulation in rats produces seizures, loss of hippocampal neurons, and a deficit in spatial mapping which are reduced by prior MK-801.

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12 December 2020

Selective vulnerability of the brain: new insights into the pathophysiology of stroke

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12 December 2020

Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

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12 December 2020

The role of mammalian ionotropic receptors in synaptic plasticity: LTP, LTD and epilepsy

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12 December 2020

Neuroprotective signal transduction: relevance to stroke

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12 December 2020

Pathobiology of ischaemic stroke: an integrated view

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12 December 2020

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

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12 December 2020

Caspase pathways, neuronal apoptosis, and CNS injury

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12 December 2020

Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia

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12 December 2020

Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons

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12 December 2020

Neuroprotection by melatonin from kainate-induced excitotoxicity in rats

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12 December 2020

Dietary supplement creatine protects against traumatic brain injury

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12 December 2020

Nimodipine prevents postischemic brain damage in the early phase of focal cerebral ischemia.

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12 December 2020

Creatine and cyclocreatine attenuate MPTP neurotoxicity

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12 December 2020

Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

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12 December 2020

Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

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12 December 2020

Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons

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12 December 2020

Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury

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12 December 2020

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

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12 December 2020

Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures

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12 December 2020

Regional distribution and time-course of calpain activation following kainate-induced seizure activity in adult rat brain

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12 December 2020

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide

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12 December 2020

Nitric oxide disrupts Ca2+ homeostasis in hippocampal neurons

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12 December 2020

Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity

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12 December 2020

NMDA antagonists: antiepileptic-neuroprotective drugs with diversified neuropharmacological profiles

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12 December 2020

4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes

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12 December 2020

Protective effects of dietary docosahexaenoic acid against kainate-induced retinal degeneration in rats

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12 December 2020

Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis

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12 December 2020

ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis

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12 December 2020

Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis, and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose

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12 December 2020

Nutritional factors in stroke

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12 December 2020

Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-1328k in cultured hippocampal neurons

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12 December 2020

Kainate excitotoxicity in organotypic hippocampal slice cultures: evidence for multiple apoptotic pathways

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12 December 2020

Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons.

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12 December 2020

Caspase-Mediated Apoptosis in Neuronal Excitotoxicity Triggered by Nitric Oxide

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12 December 2020

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

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12 December 2020

Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury

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12 December 2020

Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity

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12 December 2020

Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus

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12 December 2020

Protective effect of nimodipine against ischemic neuronal damage in rat hippocampus without changing postischemic cerebral blood flow

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12 December 2020

Transforming growth factor alpha-induced expression of type 1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity.

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12 December 2020

The transcription factor NF-kappaB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor-alpha in hippocampal neurons

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12 December 2020

Modulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress

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12 December 2020

Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex

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12 December 2020

Early treatment with a novel inhibitor of lipid peroxidation (LY341122) improves histopathological outcome after moderate fluid percussion brain injury in rats

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12 December 2020

Extracellular accumulation of nitric oxide, hydrogen peroxide, and glutamate in astrocytic cultures following glutathione depletion, complex I inhibition, and/or lipopolysaccharide-induced activation

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12 December 2020

Replicating Huntington's disease phenotype in experimental animals

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12 December 2020

Mechanisms of neurodegeneration in amyotrophic lateral sclerosis

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12 December 2020

Differential effects of BDNF, ADNF9, and TNFalpha on levels of NMDA receptor subunits, calcium homeostasis, and neuronal vulnerability to excitotoxicity

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12 December 2020

A glutamate receptor channel with high affinity for domoate and kainate

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12 December 2020

Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase

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12 December 2020

Nuclear factor kappaB is a critical determinant in N-methyl-D-aspartate receptor-mediated neuroprotection

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12 December 2020

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

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12 December 2020

Transforming growth factor-beta 1 prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse neocortex from ischemic injury in vivo

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12 December 2020

Excitotoxicity and mitochondria

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12 December 2020

A role for Na+-dependent Ca2+ extrusion in protection against neuronal excitotoxicity

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12 December 2020

An anticonvulsant profile of the ketogenic diet in the rat.

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12 December 2020

Neuroprotective effects of alpha-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia

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12 December 2020

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

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12 December 2020

Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release

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12 December 2020

Spine loss and other dendritic abnormalities in epilepsy

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12 December 2020

Glutamate-induced intracellular acidification of cultured hippocampal neurons demonstrates altered energy metabolism resulting from Ca2+ loads

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12 December 2020

Cholesterol in Alzheimer's disease and tauopathy

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12 December 2020

Neurotrophin Regulation of the Developing Nervous System: Analyses of Knockout Mice

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12 December 2020

N-methyl-D-aspartate receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis

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12 December 2020

An open-label study of CP-101,606 in subjects with a severe traumatic head injury or spontaneous intracerebral hemorrhage

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12 December 2020

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

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12 December 2020

Temporal lobe epilepsy caused by domoic acid intoxication: evidence for glutamate receptor-mediated excitotoxicity in humans.

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12 December 2020

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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12 December 2020

Oligodendrocytes as providers of growth factors

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12 December 2020

Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons

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12 December 2020

Advances in the physiopathology of epileptogenesis: molecular aspects

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12 December 2020

Glia protect hippocampal neurons against excitatory amino acid-induced degeneration: involvement of fibroblast growth factor

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12 December 2020

Mitochondria and calcium: from cell signalling to cell death

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12 December 2020

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

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12 December 2020

Nimodipine prevents delayed neuronal death of sector CA1 pyramidal cells in short-term forebrain ischemia in Mongolian gerbils

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12 December 2020

Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo.

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12 December 2020

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

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12 December 2020

Kainic acid induced seizures: neurochemical and histopathological changes

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12 December 2020

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

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12 December 2020

Increased frequency of diabetes mellitus in patients with Huntington's chorea

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12 December 2020

Cerebral protection by AMPA- and NMDA-receptor antagonists administered after severe insulin-induced hypoglycemia

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12 December 2020

Basic Fibroblast Growth Factor Selectively Increases AMPA‐Receptor Subunit GluR1 Protein Level and Differentially Modulates Ca2+ Responses to AMPA and NMDA in Hippocampal Neurons

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12 December 2020

Endoplasmic reticulum calcium release is modulated by actin polymerization

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12 December 2020

Presenilin-1 mutation sensitizes oligodendrocytes to glutamate and amyloid toxicities, and exacerbates white matter damage and memory impairment in mice

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12 December 2020

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

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12 December 2020

The Actin-Severing Protein Gelsolin Modulates Calcium Channel and NMDA Receptor Activities and Vulnerability to Excitotoxicity in Hippocampal Neurons

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12 December 2020

Evidence for synaptic apoptosis

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12 December 2020

Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease

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12 December 2020

Kainate, a double agent that generates seizures: two decades of progress

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12 December 2020

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

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12 December 2020

The link between excitotoxic oligodendroglial death and demyelinating diseases

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12 December 2020

Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice

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12 December 2020

Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate

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12 December 2020

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

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12 December 2020

Pathophysiology of oligodendroglial excitotoxicity

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12 December 2020

The efficacy of intravenous nimodipine in the treatment of focal cerebral ischemia in a primate model

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12 December 2020

Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid

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12 December 2020

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

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12 December 2020

Excitatory amino acid receptors in glia: different subtypes for distinct functions?

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12 December 2020

Cell death induced by β-amyloid 1–40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis

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12 December 2020

Cyclosporin ameliorates traumatic brain-injury-induced alterations of hippocampal synaptic plasticity.

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12 December 2020

The role of excitotoxicity in neurodegenerative disease: implications for therapy

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12 December 2020

Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes

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12 December 2020

Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene

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12 December 2020

Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

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12 December 2020

Basic fibroblast growth factor (bFGF) enhances functional recovery following severe spinal cord injury to the rat

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12 December 2020

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

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12 December 2020

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

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12 December 2020

Edarabone scavenges nitric oxide

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12 December 2020

Caspase-mediated suppression of glutamate (AMPA) receptor channel activity in hippocampal neurons in response to DNA damage promotes apoptosis and prevents necrosis: implications for neurological side effects of cancer therapy and neurodegenerative

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12 December 2020

Glutamate receptors induce a burst of superoxide via activation of nitric oxide synthase in arginine-depleted neurons

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12 December 2020

Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity

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12 December 2020

Selfotel in acute ischemic stroke : possible neurotoxic effects of an NMDA antagonist

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12 December 2020

The role of Bax in glutamate-induced nerve cell death

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12 December 2020

Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo

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12 December 2020

An immunosuppressant, FK506, protects against neuronal dysfunction and death but has no effect on electrographic and behavioral activities induced by systemic kainate

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12 December 2020

Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS.

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12 December 2020

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease

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12 December 2020

Nitric oxide in neurodegeneration

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12 December 2020

Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury

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12 December 2020

Peptidyl alpha-keto amide inhibitor of calpain blocks excitotoxic damage without affecting signal transduction events

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12 December 2020

Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor.

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12 December 2020

Mouse models of Huntington's disease

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12 December 2020

Therapeutic strategies targeting caspase inhibition following spinal cord injury in rats

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12 December 2020

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

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12 December 2020

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

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12 December 2020

The role of excitotoxicity in ALS--what is the evidence?

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12 December 2020

Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice

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12 December 2020

DATATOP: a decade of neuroprotective inquiry. Parkinson Study Group. Deprenyl And Tocopherol Antioxidative Therapy Of Parkinsonism.

1 reference

12 December 2020

Taxol stabilizes [Ca2+]i and protects hippocampal neurons against excitotoxicity

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12 December 2020

Neuron-astrocyte cross-talk during synaptic transmission: physiological and neuropathological implications.

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12 December 2020

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

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12 December 2020

Corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo.

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12 December 2020

Nerve Growth Factor Attenuates Cholinergic Deficits Following Traumatic Brain Injury in Rats

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12 December 2020

Role of Bcl-2 in the brain-derived neurotrophic factor survival response

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12 December 2020

Neural transplantation for treatment of Parkinson's disease.

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12 December 2020

Role of nitric oxide in inflammation-mediated neurodegeneration.

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12 December 2020

Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons

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12 December 2020

4-hydroxynonenal, a lipid peroxidation product, rapidly accumulates following traumatic spinal cord injury and inhibits glutamate uptake

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12 December 2020

Neurotrophin-4/5 protects hippocampal and cortical neurons against energy deprivation- and excitatory amino acid-induced injury

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12 December 2020

Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I

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12 December 2020

The role of oxygen radicals in traumatic injury: clinical implications.

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12 December 2020

Prostate apoptosis response-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration

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12 December 2020

NMDA-induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria

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12 December 2020

Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity

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12 December 2020

Oxygen free radicals regulate NMDA receptor function via a redox modulatory site

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12 December 2020

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.

1 reference

12 December 2020

Anticonvulsants attenuate amyloid beta-peptide neurotoxicity, Ca2+ deregulation, and cytoskeletal pathology

1 reference

12 December 2020

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1 reference

12 December 2020

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

1 reference

12 December 2020

17?-Estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid ?-peptide and iron

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12 December 2020

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes

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12 December 2020

Dantrolene Prevents Glutamate Cytotoxicity and Ca2+Release from Intracellular Stores in Cultured Cerebral Cortical Neurons

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12 December 2020

Head and spinal cord injury

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12 December 2020

Prevention of trauma-induced neurodegeneration in infant and adult rat brain: glutamate antagonists.

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12 December 2020

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

12 December 2020

Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.

1 reference

12 December 2020

Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death

1 reference

12 December 2020

Glutamate receptors and transporters in genetic and acquired models of epilepsy

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12 December 2020

Group II metabotropic glutamate receptor activation attenuates traumatic neuronal injury and improves neurological recovery after traumatic brain injury

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12 December 2020

Trinucleotide repeat length and clinical progression in Huntington's disease

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12 December 2020

Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons

1 reference

12 December 2020

Effects of nitric oxide synthase inhibition on brain infarction in SOD-1-transgenic mice following transient focal cerebral ischemia

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12 December 2020

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

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12 December 2020

New frontiers in Alzheimer's disease genetics

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12 December 2020

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis

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12 December 2020

Basic fibroblast growth factor protects against hypoxia-ischemia and NMDA neurotoxicity in neonatal rats

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12 December 2020

Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice

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12 December 2020

Neurotrophins and basic fibroblast growth factor induce the differentiation of calbindin-containing neurons in the cerebral cortex

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12 December 2020

Caloric intake and the risk of Alzheimer disease

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12 December 2020

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

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12 December 2020

Mitochondrial control of apoptosis

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12 December 2020

The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis

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12 December 2020

Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam

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12 December 2020

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

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12 December 2020

Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain

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12 December 2020

AMPA receptor activation is rapidly toxic to cortical astrocytes when desensitization is blocked.

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12 December 2020

Prolonged pretreatment with alpha-lipoic acid protects cultured neurons against hypoxic, glutamate-, or iron-induced injury

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12 December 2020

Only certain anticonvulsants protect against kainate neurotoxicity.

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12 December 2020

GLIA: listening and talking to the synapse

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12 December 2020

Neuroprotective effects of a novel NMDA antagonist, Gacyclidine, after experimental contusive spinal cord injury in adult rats

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12 December 2020

Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide.

1 reference

12 December 2020

Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease

1 reference

12 December 2020

The lipid peroxidation product 4-hydroxynonenal facilitates opening of voltage-dependent Ca2+ channels in neurons by increasing protein tyrosine phosphorylation

1 reference

12 December 2020

Kainic acid‐induced seizures and brain damage in the rat: Role of calcium homeostasis

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12 December 2020

Pharmacological interventions for stroke: failures and future

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12 December 2020

Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation

1 reference

12 December 2020

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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12 December 2020

Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

1 reference

12 December 2020

Inflammation and glial responses in ischemic brain lesions

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12 December 2020

Central role of microglia in neonatal excitotoxic lesions of the murine periventricular white matter

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12 December 2020

Hypoxic pretreatment protects against neuronal damage of the rat hippocampus induced by severe hypoxia

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12 December 2020

Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults

1 reference

12 December 2020

Mechanisms of disease pathogenesis in amyotrophic lateral sclerosis. A central role for calcium

1 reference

12 December 2020

Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism

1 reference

12 December 2020

Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial. GAIN International Investigators

1 reference

12 December 2020

Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor

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12 December 2020

Pesticides and parkinsonism: is there an etiological link?

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12 December 2020

Activity-dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-methyl-D-aspartate

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12 December 2020

Evidence That Actin Depolymerization Protects Hippocampal Neurons against Excitotoxicity by Stabilizing [Ca2+]i

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12 December 2020

Neuroprotective effects of gelsolin during murine stroke

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12 December 2020

Neurotransmitter-mediated mechanisms of traumatic brain injury: acetylcholine and excitatory amino acids

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12 December 2020

Proteolysis of the N-methyl-d-aspartate receptor by calpain in situ

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12 December 2020

Dendritic changes in senile and presenile dementias

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12 December 2020

Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?

1 reference

12 December 2020

Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice.

1 reference

12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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12 December 2020

The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity

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12 December 2020

Protective effect of alpha-tocopherol on ischemic neuronal damage in the gerbil hippocampus

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12 December 2020

Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury

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12 December 2020

The selective vulnerability of nerve cells in Huntington's disease

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12 December 2020