Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices (Q27730898)

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A Truneh

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R W Sweet

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W A Hendrickson

Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen

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publication date

15 January 1994

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59-74

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Interaction between CD4 and class II MHC molecules mediates cell adhesion

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Direct evidence for binding of CD8 to HLA class I antigens

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Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

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Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

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Acquisition of immunologic self-tolerance

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CD4: collaborator in immune recognition and HIV infection

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The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

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Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule

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Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

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Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

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Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis

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7 January 2021

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

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7 January 2021

Crystal structure of an HIV-binding recombinant fragment of human CD4.

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7 January 2021

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

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7 January 2021

Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2-terminal domains

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7 January 2021

CD4: its structure, role in immune function and AIDS pathogenesis, and potential as a pharmacological target

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7 January 2021

Design and synthesis of a CD4 beta-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes

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7 January 2021

Soluble forms of the human T cell receptor CD4 are efficiently expressed by Streptomyces lividans

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7 January 2021

Enzymatic cleavage of a CD4 immunoadhesin generates crystallizable, biologically active Fd-like fragments

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7 January 2021

Crystal structure of chaperone protein PapD reveals an immunoglobulin fold

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The anatomy and taxonomy of protein structure

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Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding

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Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4.

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7 January 2021

Identification of the residues in human CD4 critical for the binding of HIV.

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7 January 2021

Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis

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7 January 2021

The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure

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7 January 2021

Construction of a binding site for human immunodeficiency virus type 1 gp120 in rat CD4

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Structure and interactions of CD4

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Identification of a CD4 binding site on the beta 2 domain of HLA-DR molecules.

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7 January 2021

Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding

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7 January 2021

The MHC-binding and gp120-binding functions of CD4 are separable

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7 January 2021

Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite the gp120-binding site

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7 January 2021

Human immunodeficiency virus gp120 binding C'C" ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules

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7 January 2021

Structural aspects of CD4 and CD8 involvement in the cellular immune response

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7 January 2021

Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex binding

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7 January 2021

Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals

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7 January 2021

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

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7 January 2021

Radiation damage in protein crystallography

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7 January 2021

Crystallographic R factor refinement by molecular dynamics

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7 January 2021

The detection of sub-units within the crystallographic asymmetric unit

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7 January 2021

A graphics model building and refinement system for macromolecules

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7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

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7 January 2021

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

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7 January 2021