Chymotrypsin C mutations in chronic pancreatitis (Q27693296)

title

Chymotrypsin C mutations in chronic pancreatitis (English)

1 reference

1 reference

Miklós Sahin-Tóth

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21631589

3 December 2024

Jiayi Zhou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21631589

3 December 2024

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21631589

3 December 2024

publication date

August 2011

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full work available at URL

https://europepmc.org/articles/pmc3142265?pdf=render

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21631589

https://europepmc.org/articles/PMC3142265

3 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21631589

https://europepmc.org/articles/PMC3142265?pdf=render

3 December 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21631589

https://doi.org/10.1111/j.1440-1746.2011.06791.x

3 December 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21631589

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1440-1746.2011.06791.x

3 December 2024

1 reference

10.1111/J.1440-1746.2011.06791.X

DOI

https://api.crossref.org/works/10.1111/J.1440-1746.2011.06791.X

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1440-1746.2011.06791.x

3 December 2024

1 reference

10.1111/J.1440-1746.2011.06791.X

DOI

https://api.crossref.org/works/10.1111/J.1440-1746.2011.06791.X

Journal of Gastroenterology and Hepatology

3 December 2024

published in

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1 reference

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1238-46

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Uncertainties in the classification of human cationic trypsinogen (PRSS1) variants as hereditary pancreatitis-associated mutations

cites work

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Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism

20 March 2017

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Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

20 March 2017

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Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y

20 March 2017

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Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis

20 March 2017

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Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis

20 March 2017

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Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

20 March 2017

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Molecular cloning and expression of human caldecrin

20 March 2017

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The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C

20 March 2017

1 reference

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Signal integration in the endoplasmic reticulum unfolded protein response

20 March 2017

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SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis

20 March 2017

1 reference

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Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis

20 March 2017

1 reference

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A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Clinical and genetic characteristics of hereditary pancreatitis in Europe

20 March 2017

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Pedigree of a family with hereditary chronic relapsing pancreatitis

20 March 2017

1 reference

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Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin

20 March 2017

1 reference

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Smoking Is Underrecognized as a Risk Factor for Chronic Pancreatitis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Alcohol and Smoking as Risk Factors in an Epidemiology Study of Patients With Chronic Pancreatitis

29 September 2017

1 reference

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Smoking as a cofactor for causation of chronic pancreatitis: a meta-analysis

29 September 2017

1 reference

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Serum calcium-decreasing factor, caldecrin, inhibits osteoclast differentiation by suppression of NFATc1 activity

29 September 2017

1 reference

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Genetic aspects of pancreatitis

29 September 2017

1 reference

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Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells

29 September 2017

1 reference

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Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell death

29 September 2017

1 reference

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Chronic pancreatitis: genetics and pathogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants

29 September 2017

1 reference

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Minigene analysis of intronic variants in common SPINK1 haplotypes associated with chronic pancreatitis.

29 September 2017

1 reference

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Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis

29 September 2017

1 reference

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Trypsinogen copy number mutations in patients with idiopathic chronic pancreatitis

29 September 2017

1 reference

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Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation

29 September 2017

1 reference

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Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy.

29 September 2017

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Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

29 September 2017

1 reference

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Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

The chemical structure and enzymatic functions of bovine procarboxypeptidase A.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Studies of intestinal digestion and absorption in the human

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Mechanisms of intestinal calcium absorption

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Chronic pancreatitis: diagnosis, classification, and new genetic developments

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Mutations of the cystic fibrosis gene in patients with chronic pancreatitis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Advances in metallo-procarboxypeptidases. Emerging details on the inhibition mechanism and on the activation process

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

The tetra-aspartate motif in the activation peptide of human cationic trypsinogen is essential for autoactivation control but not for enteropeptidase recognition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Human cationic trypsinogen. Role of Asn-21 in zymogen activation and implications in hereditary pancreatitis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Diabetes mellitus and cerebrovascular disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Linkage studies in a large kindred with hereditary pancreatitis confirms mapping of the gene to a 16-cM region on 7q.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Existence of ternary complexes of procarboxypeptidase A in the pancreas of some ruminant species

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142265

Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis.

19 June 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2011.06791.X

Evolution of trypsinogen activation peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2011.06791.X

[-215G>A; IVS3+2T>C] mutation in the SPINK1 gene causes exon 3 skipping and loss of the trypsin binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2011.06791.X

Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2011.06791.X

Molecular cloning and expression of serum calcium-decreasing factor (caldecrin).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2011.06791.X

Human cationic trypsinogen. Arg(117) is the reactive site of an inhibitory surface loop that controls spontaneous zymogen activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2011.06791.X

Calcium Solubility, Intestinal Sojourn Time and Paracellular Permeability Codetermine Passive Calcium Absorption in Rats

21 January 2018

1 reference

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The First International Symposium on Hereditary Pancreatitis

27 November 2018

1 reference

12 December 2020

CHYMOTRYPSIN C. II. ENZYMATIC SPECIFICITY TOWARD SEVERAL POLYPEPTIDES

1 reference

12 December 2020

Hereditary pancreatitis caused by triplication of the trypsinogen locus

1 reference

12 December 2020

CHYMOTRYPSIN C. I. ISOLATION OF THE ZYMOGEN AND THE ACTIVE ENZYME: PRELIMINARY STRUCTURE AND SPECIFICITY STUDIES

1 reference

12 December 2020

Multifactorial genesis of pancreatitis in primary hyperparathyroidism: evidence for "protective" (PRSS2) and "destructive" (CTRC) genetic factors

1 reference

12 December 2020

Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene

1 reference

12 December 2020

On subunit II of bovine procarboxypeptidase A. Enzymatic specificity after tryptic activation

1 reference

12 December 2020

Active forms of chymotrypsin C isolated from autolyzed porcine pancreas glands

1 reference

12 December 2020

Metabolism of 131I-labelled human pancreatic cationic trypsin after intraduodenal administration

1 reference

12 December 2020

Fate of pancreatic enzymes during small intestinal aboral transit in humans

1 reference

12 December 2020

A possible zymogen self-destruct mechanism preventing pancreatic autodigestion

1 reference

12 December 2020

Serum calcium-decreasing factor (caldecrin) from porcine pancreas has proteolytic activity which has no clear connection with the calcium decrease

1 reference

12 December 2020

1 reference

12 December 2020

A gene for hereditary pancreatitis maps to chromosome 7q35

1 reference

12 December 2020

The hereditary pancreatitis gene maps to long arm of chromosome 7

1 reference

12 December 2020

10.1111/J.1440-1746.2011.06791.X

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DOI

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