Insights into Phosphate Cooperativity and Influence of Substrate Modifications on Binding and Catalysis of Hexameric Purine Nucleoside Phosphorylases (Q27672664)

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English	Insights into Phosphate Cooperativity and Influence of Substrate Modifications on Binding and Catalysis of Hexameric Purine Nucleoside Phosphorylases	scientific article

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12 February 2020

Insights into phosphate cooperativity and influence of substrate modifications on binding and catalysis of hexameric purine nucleoside phosphorylases (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957058%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Humberto M Pereira

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12 February 2020

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Priscila O de Giuseppe

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12 February 2020

Nadia H Martins

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12 February 2020

Andreia N Meza

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12 February 2020

Camila R dos Santos

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12 February 2020

Mario T Murakami

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12 February 2020

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5 September 2012

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12 February 2020

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12 February 2020

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12 February 2020

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12 February 2020

e44282

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12 February 2020

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Creative Commons Attribution 4.0 International

5 September 2012

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0 references

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Structural basis of the substrate specificity ofBacillus cereusadenosine phosphorylase

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Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies

1 reference

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Structural basis for selective inhibition of purine nucleoside phosphorylase from Schistosoma mansoni: kinetic and structural studies

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MolProbity: all-atom structure validation for macromolecular crystallography

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Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2′-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine

1 reference

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Inhibition and Structure of Trichomonas vaginalis Purine Nucleoside Phosphorylase with Picomolar Transition State Analogues †

1 reference

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20 March 2017

Role of purine nucleoside phosphorylase in interactions between 2',3'-dideoxyinosine and allopurinol, ganciclovir, or tenofovir

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Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system

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20 March 2017

Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase

1 reference

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Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir

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Open and closed conformation of the E. coli purine nucleoside phosphorylase active center and implications for the catalytic mechanism

1 reference

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20 March 2017

The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology

1 reference

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20 March 2017

Purine Nucleoside Phosphorylase. 1. Structure−Function Studies

1 reference

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20 March 2017

Phasercrystallographic software

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20 March 2017

Inference of macromolecular assemblies from crystalline state

1 reference

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The integration of macromolecular diffraction data

1 reference

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Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

1 reference

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Coot: model-building tools for molecular graphics

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Refinement of macromolecular structures by the maximum-likelihood method

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20 March 2017

The CCP4 suite: programs for protein crystallography

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20 March 2017

Structural analyses reveal two distinct families of nucleoside phosphorylases

1 reference

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Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase.

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29 September 2017

Molecular cloning, overexpression, purification, crystallization and preliminary X-ray diffraction analysis of a purine nucleoside phosphorylase from Bacillus subtilis strain 168.

1 reference

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Discovery of new inhibitors of Schistosoma mansoni PNP by pharmacophore-based virtual screening.

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Enhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene

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Four generations of transition-state analogues for human purine nucleoside phosphorylase.

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Herpes simplex virus resistance to antiviral drugs

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Antitumor activity of 2-fluoro-2'-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase

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inferred from PubMed ID database lookup

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based on heuristic

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10.1371/JOURNAL.PONE.0044282

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Europe PubMed Central

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12 February 2020

2012PLoSO...744282D

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Europe PubMed Central

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12 February 2020

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Europe PubMed Central

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12 February 2020

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