A novel ATP-dependent conformation in p97 N–D1 fragment revealed by crystal structures of disease-related mutants (Q27662051)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Wai Kwan Tang

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Dongyang Li

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Chou-chi Li

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Lothar Esser

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Renming Dai

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Liang Guo

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Di Xia

The crystal structure of murine p97/VCP at 3.6A

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language of work or name

English

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publication date

7 July 2010

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2217-29

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cites work

1 reference

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Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4.

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Crystal structure of ClpA, an Hsp100 chaperone and regulator of ClpAP protease

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Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation

20 March 2017

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Structure of the AAA ATPase p97

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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Likelihood-enhanced fast rotation functions

20 March 2017

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The interpretation of protein structures: Estimation of static accessibility

20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

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Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone

22 April 2017

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AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes

20 March 2017

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Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

20 March 2017

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Motions and negative cooperativity between p97 domains revealed by cryo-electron microscopy and quantised elastic deformational model

20 March 2017

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Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle

20 March 2017

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Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation

20 March 2017

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UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97

20 March 2017

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Conformational changes in the AAA ATPase p97-p47 adaptor complex

20 March 2017

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Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase

20 March 2017

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Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation

20 March 2017

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Nucleotide dependent motion and mechanism of action of p97/VCP

20 March 2017

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Molecular perspectives on p97-VCP: progress in understanding its structure and diverse biological functions

20 March 2017

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Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants

20 March 2017

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The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97

20 March 2017

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Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase

20 March 2017

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Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

20 March 2017

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Purification, crystallization and preliminary X-ray diffraction analysis of disease-related mutants of p97.

7 April 2017

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The use of blue native PAGE in the evaluation of membrane protein aggregation states for crystallization

29 September 2017

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Pathological consequences of VCP mutations on human striated muscle

29 September 2017

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The N-terminal substrate-binding domain of ClpA unfoldase is highly mobile and extends axially from the distal surface of ClpAP protease

2 June 2018

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Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering

2 June 2018

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A novel mutation in the VCP gene (G157R) in a German family with inclusion-body myopathy with Paget disease of bone and frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.104

VAT, the thermoplasma homolog of mammalian p97/VCP, is an N domain-regulated protein unfoldase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.104

Two Australian families with inclusion-body myopathy, Paget's disease of bone and frontotemporal dementia: novel clinical and genetic findings

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.104

Mutant valosin-containing protein causes a novel type of frontotemporal dementia

21 January 2018

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Novel VCP mutations in inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.104

Inclusion body myopathy and Paget disease is linked to a novel mutation in the VCP gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.104

p97, a protein coping with multiple identities

21 January 2018

1 reference

12 December 2020

A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting

1 reference

12 December 2020

Going through the motions: The ATPase cycle of p97

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Low-affinity binding determined by titration calorimetry using a high-affinity coupling ligand: a thermodynamic study of ligand binding to protein tyrosine phosphatase 1B

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2010.104

1 reference

1 reference

1 reference

PubMed publication ID

20512113

1 reference