Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel (Q27664399)

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English	Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel	scientific article

Statements

instance of

scholarly article

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title

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel (English)

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main subject

cell biology

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HCN channel complex

1 reference

stated in

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0098855

author

Xinping Xu

object named as

Xinping Xu

series ordinal

1

1 reference

stated in

ORCID Public Data File 2021

author name string

Zhanna V Vysotskaya

series ordinal

2

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Qinglian Liu

series ordinal

3

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Lei Zhou

series ordinal

4

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language of work or name

English

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publication date

19 November 2010

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published in

Journal of Biological Chemistry

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volume

285

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issue

47

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page(s)

37082-91

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cites work

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Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4

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Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions

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Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide

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The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides

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The Contribution of HCN4 to normal sinus node function in humans and animal models

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Hyperpolarization-activated cation channels: from genes to function

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Mouse models for studying pacemaker channel function and sinus node arrhythmia

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29 September 2017

Pacemaker activity of the human sinoatrial node: role of the hyperpolarization-activated current, I(f).

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29 September 2017

Genesis and regulation of the heart automaticity.

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29 September 2017

Molecular basis of funny current (If) in normal and failing human heart.

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29 September 2017

Pathway and endpoint free energy calculations for cyclic nucleotide binding to HCN channels

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Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.

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29 September 2017

Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy

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29 September 2017

Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels

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29 September 2017

Functional expression of the human HCN3 channel

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Cardiac pacemaker I(f) current and its inhibition by heart rate-reducing agents

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29 September 2017

Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels

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29 September 2017

Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia

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29 September 2017

Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels

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29 September 2017

The S4-S5 linker couples voltage sensing and activation of pacemaker channels.

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PubMed Central

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29 September 2017

The eag family of K+ channels in Drosophila and mammals

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29 September 2017

Structure and function of cyclic nucleotide-gated channels

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29 September 2017

Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling

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2 June 2018

A State-independent Interaction between Ligand and a Conserved Arginine Residue in Cyclic Nucleotide-gated Channels Reveals a Functional Polarity of the Cyclic Nucleotide Binding Site

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2 June 2018

Molecular mechanism of cAMP modulation of HCN pacemaker channels.

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Rotational movement during cyclic nucleotide-gated channel opening

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Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes

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21 January 2018

Voltage-dependent gating of hyperpolarization-activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4-S5 and C-linkers

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21 January 2018

A conserved tripeptide in CNG and HCN channels regulates ligand gating by controlling C-terminal oligomerization

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Pacemaking by HCN channels requires interaction with phosphoinositides

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A superfamily of ion channels

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Regulation of hyperpolarization-activated HCN channels by cAMP through a gating switch in binding domain symmetry

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Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart

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Identifiers

DOI

10.1074/JBC.M110.152033

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PMC publication ID

2978636

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PubMed publication ID

20829353

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