A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters (Q27650857)

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Stefan Anemüller

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Shuai Chen

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Jeroen R Mesters

Neuroinvasion by human respiratory coronaviruses

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publication date

June 2008

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published in

Chemistry and Biology

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volume

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issue

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page(s)

597-606

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cites work

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12 December 2020

Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease

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12 December 2020

Crystal structures reveal an induced-fit binding of a substrate-like Aza-peptide epoxide to SARS coronavirus main peptidase

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12 December 2020

Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus

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12 December 2020

Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide

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12 December 2020

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

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12 December 2020

pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses

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12 December 2020

Structures of Two Coronavirus Main Proteases: Implications for Substrate Binding and Antiviral Drug Design

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12 December 2020

SARS CoV main proteinase: The monomer-dimer equilibrium dissociation constant

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12 December 2020

Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate

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12 December 2020

Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China

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12 December 2020

The CCP4 suite: programs for protein crystallography

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12 December 2020

Characterization of a human coronavirus (strain 229E) 3C-like proteinase activity

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12 December 2020

Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations

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12 December 2020

A novel coronavirus associated with severe acute respiratory syndrome

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12 December 2020

Conservation of substrate specificities among coronavirus main proteases

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12 December 2020

Determination of the rate constant of enzyme modification by measuring the substrate reaction in the presence of the modifier.

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12 December 2020

Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase

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Coronavirus HKU1 and other coronavirus infections in Hong Kong

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A previously undescribed coronavirus associated with respiratory disease in humans

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Refinement of macromolecular structures by the maximum-likelihood method

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SARS: systematic review of treatment effects

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12 December 2020

Structure of alpha-chymotrypsin refined at 1.68 A resolution

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12 December 2020

Common Adverse Events Associated with the Use of Ribavirin for Severe Acute Respiratory Syndrome in Canada

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12 December 2020

Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease

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12 December 2020

A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methods

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12 December 2020

Small molecules targeting severe acute respiratory syndrome human coronavirus

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Identification of a novel coronavirus in patients with severe acute respiratory syndrome

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12 December 2020

Virus-encoded proteinases and proteolytic processing in the Nidovirales.

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12 December 2020

Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction

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12 December 2020

Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining the extra domain as a new target for design of highly specific protease inhibitors

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12 December 2020

Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies

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12 December 2020

Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro.

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12 December 2020

Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease.

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12 December 2020

Mechanisms and enzymes involved in SARS coronavirus genome expression

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12 December 2020

Two cases of severe obstructive pneumonia associated with an HKU1-like coronavirus

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12 December 2020

Mosaic structure of human coronavirus NL63, one thousand years of evolution

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12 December 2020

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

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12 December 2020

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain

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12 December 2020

Coot: model-building tools for molecular graphics

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12 December 2020

The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity

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12 December 2020

Critical assessment of important regions in the subunit association and catalytic action of the severe acute respiratory syndrome coronavirus main protease.

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12 December 2020

Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the side-chain length of the penultimate amino acid

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12 December 2020

Identification of a new human coronavirus

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12 December 2020

Design of wide-spectrum inhibitors targeting coronavirus main proteases

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12 December 2020

Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia

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12 December 2020

An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors

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12 December 2020

Sometimes intermediates. Do the job!

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12 December 2020

Mechanism of the maturation process of SARS-CoV 3CL protease

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12 December 2020

Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro

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12 December 2020

Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening

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12 December 2020

Coronavirus as a possible cause of severe acute respiratory syndrome

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12 December 2020

The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme

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12 December 2020

Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide.

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12 December 2020

Efficient and rapid affinity purification of proteins using recombinant fusion proteases

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12 December 2020

Structure of the SARS coronavirus main proteinase as an active C2 crystallographic dimer

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020