Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities (Q27650138)

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Suneil Malik

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Anna Vinogradova

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Ping Wang

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Zhigang Chen

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Ping Xu

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Hugh P J Bennett

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Andrew Bateman

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Feng Ni

Solution structures of a 30-residue amino-terminal domain of the carp granulin-1 protein and its amino-terminally truncated 3-30 subfragment: implications for the conformational stability of the stack of two beta-hairpins

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publication date

April 2008

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711-24

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cites work

2 references

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20 March 2017

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A peptide derived from the C-terminal part of a plant cysteine protease folds into a stack of two beta-hairpins, a scaffold present in the emerging family of granulin-like growth factors

27 November 2018

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Design and solution structure of a well-folded stack of two beta-hairpins based on the amino-terminal fragment of human granulin A

20 March 2017

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A 30-residue fragment of the carp granulin-1 protein folds into a stack of two beta-hairpins similar to that found in the native protein

20 March 2017

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Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor)

20 March 2017

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Characterisation of UGP and its relationship with beta-core fragment

20 March 2017

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Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains

20 March 2017

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20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

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20 March 2017

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How to measure and predict the molar absorption coefficient of a protein

20 March 2017

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

20 March 2017

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Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo

20 March 2017

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

20 March 2017

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Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

20 March 2017

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Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line

20 March 2017

1 reference

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Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells

20 March 2017

1 reference

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Granulins, a novel class of peptide from leukocytes

20 March 2017

1 reference

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The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth

20 March 2017

1 reference

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Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats

20 March 2017

1 reference

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Automated assignment of ambiguous nuclear overhauser effects with ARIA

20 March 2017

1 reference

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Use of a water flip-back pulse in the homonuclear NOESY experiment

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Oncogenic property of acrogranin in human uterine leiomyosarcoma: direct evidence of genetic contribution in in vivo tumorigenesis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis

29 September 2017

1 reference

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PC cell-derived growth factor (granulin precursor) expression and action in human multiple myeloma

29 September 2017

1 reference

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The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer.

29 September 2017

1 reference

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Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Progranulin is a mediator of the wound response

29 September 2017

1 reference

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Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival.

29 September 2017

1 reference

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Granulin precursor gene: a sex steroid-inducible gene involved in sexual differentiation of the rat brain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Determination of the disulfide structure of sillucin, a highly knotted, cysteine-rich peptide, by cyanylation/cleavage mass mapping

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Differential gene expression profiling in human brain tumors

29 September 2017

1 reference

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Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Cellular localization of gene expression for progranulin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Biological activities and signaling pathways of the granulin/epithelin precursor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

J-multiplied HSQC (MJ-HSQC): a new method for measuring 3J(HNHalpha) couplings in 15N-labeled proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

The granulin/epithelin precursor abrogates the requirement for the insulin-like growth factor 1 receptor for growth in vitro.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Optimization of the cleavage reaction for cyanylated cysteinyl proteins for efficient and simplified mass mapping

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

A novel methodology for assignment of disulfide bond pairings in proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Determination of the disulphide bonding pattern in proteins by local and global analysis of nuclear magnetic resonance data. Application to flavoridin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Determinants of strand register in antiparallel beta-sheets of proteins

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Identification of a sex steroid-inducible gene in the neonatal rat hypothalamus

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

The role of the thioredoxin and glutaredoxin pathways in reducing protein disulfide bonds in the Escherichia coli cytoplasm.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Two-step selective formation of three disulfide bridges in the synthesis of the C-terminal epidermal growth factor-like domain in human blood coagulation factor IX

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Conformation of beta hairpins in protein structures: classification and diversity in homologous structures

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

PC cell-derived growth factor overexpression promotes proliferation and survival of laryngeal carcinoma.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Granulin-epithelin precursor is a novel prognostic marker in epithelial ovarian carcinoma

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

PC cell-derived growth factor mediates tamoxifen resistance and promotes tumor growth of human breast cancer cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

PC cell-derived growth factor expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Expression of PC-cell-derived growth factor in benign and malignant human breast epithelium

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Induction of granulin precursor gene expression by estrogen treatment in neonatal rat hypothalamus

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Modulation of mouse preimplantation embryo development by acrogranin (epithelin/granulin precursor).

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Deprotection of S-acetamidomethyl cysteine-containing peptides by silver trifluoromethanesulfonate avoids the oxidation of methionines.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Isolation and primary structure of the three major forms of granulin-like peptides from hematopoietic tissues of a teleost fish (Cyprinus carpio).

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

The complementary deoxyribonucleic acid sequence, tissue distribution, and cellular localization of the rat granulin precursor

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2271164

Granulins: the structure and function of an emerging family of growth factors

27 November 2018

1 reference

12 December 2020

Immunocytochemical localization of granulin-1 to mononuclear phagocytic cells of the teleost fish Cyprinus carpio and Carassius auratus

1 reference

12 December 2020

Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium

1 reference

12 December 2020

Isolation and N-Terminal Sequence of Multiple Forms of Granulins in Human Urine

1 reference

12 December 2020

Beta-hairpins in proteins revisited: lessons for de novo design

1 reference

12 December 2020

Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex

1 reference

12 December 2020

Identifiers

DOI

10.1110/PS.073295308

1 reference

1 reference

1 reference

PubMed publication ID

18359860

1 reference