Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling (Q27655822)

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Hidehito Tochio

0 references

Zenichiro Kato

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Kenji E Orii

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Ailian Li

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Takeshi Kimura

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Hidekazu Hiroaki

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Naomi Kondo

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

23 June 2009

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published in

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volume

106

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issue

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page(s)

10260-5

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cites work

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The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer

20 March 2017

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The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

20 March 2017

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Binding specificity of Toll-like receptor cytoplasmic domains

20 March 2017

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Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

20 March 2017

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20 March 2017

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The cloning and characterization of human MyD88: a member of an IL-1 receptor related family

20 March 2017

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Pathogen recognition and innate immunity

20 March 2017

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Automated NMR structure calculation with CYANA

20 March 2017

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

7 April 2017

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20 March 2017

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22 April 2017

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20 March 2017

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Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation

20 March 2017

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TIRAP: an adapter molecule in the Toll signaling pathway

20 March 2017

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Accurate modeling of protein conformation by automatic segment matching

20 March 2017

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

20 March 2017

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

20 March 2017

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A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

20 March 2017

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Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

20 March 2017

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Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

20 March 2017

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MyD88, an adapter protein involved in interleukin-1 signaling

20 March 2017

1 reference

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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

20 March 2017

1 reference

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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Structure and regulation of cytoplasmic adapter proteins involved in innate immune signaling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Positioning of autoimmune TCR-Ob.2F3 and TCR-Ob.3D1 on the MBP85-99/HLA-DR2 complex

29 September 2017

1 reference

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The RXRalpha C-terminus T462 is a NMR sensor for coactivator peptide binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Signaling to NF-kappaB by Toll-like receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Prediction of protein three-dimensional structures in insertion and deletion regions: a procedure for searching data bases of representative protein fragments using geometric scoring criteria.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Prediction of the structure of a receptor-protein complex using a binary docking method

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693180

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0812956106

Distributed automated docking of flexible ligands to proteins: Parallel applications of AutoDock 2.4

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0812956106

21 January 2018

Identifiers

DOI

10.1073/PNAS.0812956106

1 reference

release_n4df3tzg3bgcjisk6e32vrnxyq

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/n4df3tzg3bgcjisk6e32vrnxyq

mapped directly with Wikidata item

24 November 2022

based on heuristic

2024708

1 reference

1 reference

2024708

PubMed publication ID

19506249

1 reference