Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition (Q27641108)

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3 November 2019

title

Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition (English)

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3 November 2019

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3 November 2019

Matthew R Redinbo

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3 November 2019

Sompop Bencharit

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3 November 2019

Christopher L Morton

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3 November 2019

Janice L Hyatt

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3 November 2019

Peter Kuhn

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3 November 2019

Mary K Danks

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3 November 2019

publication date

1 April 2003

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3 November 2019

published in

Chemistry and Biology

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3 November 2019

volume

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issue

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3 November 2019

page(s)

341-349

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Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases.

3 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

The mammalian carboxylesterases: from molecules to functions

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Lipases and carboxylesterases: possible roles in the hepatic metabolism of retinol

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Current progress on esterases: from molecular structure to function

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Involvement of liver carboxylesterases in the in vitro metabolism of lidocaine

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Variable activation of lovastatin by hydrolytic enzymes in human plasma and liver. 4

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Hydrolytic Profile for Ester- or Amide-linkage by Carboxylesterases pI 5.3 and 4.5 from Human Liver

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Identification of two tamoxifen target proteins by photolabeling with 4-(2-morpholinoethoxy)benzophenone

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Setting the standards: quality control in the secretory pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Identification of human liver carboxylesterase as one of the proteins involved in Plasmodium falciparum malaria sporozoite invasion in primary cultures of human hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

The beta-glucuronidase propeptide contains a serpin-related octamer necessary for complex formation with egasyn esterase and for retention within the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Identification of a C-reactive protein binding site in two hepatic carboxylesterases capable of retaining C-reactive protein within the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

C-reactive protein, arterial endothelial activation, and development of transplant coronary artery disease: a prospective study

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Efficacy of acetylcholinesterase inhibitors versus nootropics in Alzheimer's disease: a retrospective, longitudinal study

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

A rapid method for positioning small flexible molecules, nucleic acids, and large protein fragments in experimental electron density maps

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Open "back door" in a molecular dynamics simulation of acetylcholinesterase.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

"Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Homodimeric tacrine congeners as acetylcholinesterase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Novel tacrine derivatives that block neuronal calcium channels.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Heterodimeric Tacrine-Based Acetylcholinesterase Inhibitors: Investigating Ligand−Peripheral Site Interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Structural mechanisms of QacR induction and multidrug recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Comparison of Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Spodoptera frugiperda, and COS7 cells for recombinant gene expression. Application to a rabbit liver carboxylesterase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

AMoRe: an automated package for molecular replacement

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Improved Fourier coefficients for maps using phases from partial structures with errors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Further additions to MolScript version 1.4, including reading and contouring of electron-density maps

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Raster3D Version 2.0. A program for photorealistic molecular graphics

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Analytical study of microsomes and isolated subcellular membranes from rat liver. I. Biochemical methods

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

A new and rapid colorimetric determination of acetylcholinesterase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

Microtiter assay for acetylcholinesterase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900071-1

7 January 2021

10.1016/S1074-5521(03)00071-1

Identifiers

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3 November 2019

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