General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues (Q27477760)

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scientific article (publication date: December 2006)

Language	Label	Description	Also known as
English	General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues	scientific article (publication date: December 2006)

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scholarly article

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General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues (English)

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Hepatitis C virus

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based on heuristic

inferred from title

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based on heuristic

inferred from title

4

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Hélène Dutartre

1

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author name string

Cécile Bussetta

2

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Joëlle Boretto

3

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language of work or name

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publication date

December 2006

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Antimicrobial Agents and Chemotherapy

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50

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12

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4161-9

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Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693996

21 March 2017

Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay

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Inhibitory Effect of 2'-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon Cells

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A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties

1 reference

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Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor

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Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation

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21 March 2017

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

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A mechanism for initiating RNA-dependent RNA polymerization

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Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase

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21 March 2017

De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase

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21 March 2017

De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus

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21 March 2017

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

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21 March 2017

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

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A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA.

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

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21 March 2017

Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection

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21 March 2017

Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial

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21 March 2017

Hepatitis C virus infection

1 reference

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21 March 2017

Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group

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VMD: visual molecular dynamics

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A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

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Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose

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Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase

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Challenges and successes in developing new therapies for hepatitis C.

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Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors.

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Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective

1 reference

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29 September 2017

Rationale for maintenance of the M184v resistance mutation in human immunodeficiency virus type 1 reverse transcriptase in treatment experienced patients

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The impact of the M184V substitution on drug resistance and viral fitness

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Progress and development of small molecule HCV antivirals.

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The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation

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Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate

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Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

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Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives

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Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

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In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061.

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A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions

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Excision of incorporated nucleotide analogue chain-terminators can diminish their inhibitory effects on viral RNA-dependent RNA polymerases

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Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations

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Multiple interactions within the hepatitis C virus RNA polymerase repress primer-dependent RNA synthesis

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Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression

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Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

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27 November 2018

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