Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator (Q27343160)

26 June 2017

title

Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator (English)

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26 June 2017

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Jun-Ichi Okada

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Junko Kurokawa

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Takashi Yoshinaga

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26 June 2017

Takumi Washio

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26 June 2017

Tetsushi Furukawa

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26 June 2017

Kohei Sawada

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26 June 2017

Seiryo Sugiura

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26 June 2017

Toshiaki Hisada

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26 June 2017

language of work or name

English

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publication date

1 May 2015

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26 June 2017

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26 June 2017

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26 June 2017

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26 June 2017

page(s)

e1400142

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Drug induced QT prolongation and torsades de pointes

26 June 2017

cites work

1 reference

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21 March 2017

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Late cardiac sodium current can be assessed using automated patch-clamp

21 March 2017

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MICE models: superior to the HERG model in predicting Torsade de Pointes

29 September 2017

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Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

29 September 2017

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Current pharmacogenomic studies on hERG potassium channels

29 September 2017

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Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials

29 September 2017

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Multi-scale simulations of cardiac electrophysiology and mechanics using the University of Tokyo heart simulator

29 September 2017

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Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.

29 September 2017

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Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk

29 September 2017

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In silico risk assessment for drug-induction of cardiac arrhythmia

29 September 2017

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Key clinical considerations for demonstrating the utility of preclinical models to predict clinical drug-induced torsades de pointes

29 September 2017

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Cellular basis for the repolarization waves of the ECG.

29 September 2017

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A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes

29 September 2017

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Drugs, QTc interval prolongation and final ICH E14 guideline : an important milestone with challenges ahead

29 September 2017

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29 September 2017

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Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

29 September 2017

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

29 September 2017

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Simulating the electrical behavior of cardiac tissue using the bidomain model

29 September 2017

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How the anisotropy of the intracellular and extracellular conductivities influences stimulation of cardiac muscle

29 September 2017

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29 September 2017

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2 June 2018

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27 November 2018

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27 November 2018

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27 November 2018

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Clarithromycin reduces Isus and Ito currents in human atrial myocytes with minor repercussions on action potential duration

27 November 2018

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Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels

27 November 2018

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27 November 2018

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Advancing Regulatory Science

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Revolution dawning in cardiotoxicity testing

1 reference

12 December 2020

Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia

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12 December 2020

Transmural and apicobasal gradients in repolarization contribute to T-wave genesis in human surface ECG

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12 December 2020

Identifiers

DOI

10.1126/SCIADV.1400142

1 reference

release_oo57xbvr5fbetkqdbgnyku5o5y

26 June 2017

Fatcat ID

0 references

OpenCitations bibliographic resource ID

1550083

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1550083

1 reference