PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila (Q27315571)

Creative Commons Attribution 4.0 International

GOA release 2020-03-11

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Nobutaka Hattori

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Kahori Shiba-Fukushima

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object named as

Kahori Shiba-Fukushima

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author name string

Tsuyoshi Inoshita

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Yuzuru Imai

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language of work or name

English

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publication date

June 2014

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e1004391

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start time

5 June 2014

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April 2022 Public Data File from Crossref

copyrighted

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describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4046931/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria

21 March 2017

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PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

21 March 2017

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PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

21 March 2017

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

21 March 2017

1 reference

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 March 2017

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 March 2017

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 March 2017

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

21 March 2017

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 March 2017

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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

7 April 2017

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Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

7 April 2017

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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

7 April 2017

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

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Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

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The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

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Dopaminergic expression of the Parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy.

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PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

28 September 2017

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PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

28 September 2017

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PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

28 September 2017

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28 September 2017

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Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts

28 September 2017

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28 September 2017

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The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila

28 September 2017

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The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway

28 September 2017

1 reference

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Parkin stabilizes PINK1 through direct interaction

28 September 2017

1 reference

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PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

28 September 2017

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Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein

28 September 2017

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Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

28 September 2017

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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046931

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046931

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046931

Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046931

Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance

31 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046931

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

31 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004391

Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004391

Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004391

Impaired in vivo dopamine release in parkin knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004391

The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004391

Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24901221

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1004391

1 reference

1 reference

1 reference

PubMed publication ID

24901221

1 reference