Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content (Q27305332)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26020641%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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12 June 2020

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12 June 2020

Evelyn Zacharewicz

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12 June 2020

Derk Pol

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12 June 2020

Robert S Lee-Young

series ordinal

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12 June 2020

Rod J Snow

series ordinal

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12 June 2020

language of work or name

English

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publication date

2015

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published in

PLOS One

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12 June 2020

volume

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12 June 2020

issue

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12 June 2020

page(s)

e0128398

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Creative Commons Attribution 4.0 International

12 June 2020

start time

28 May 2015

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

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28 September 2017

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28 September 2017

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Regulation of muscle pyruvate dehydrogenase complex in insulin resistance: effects of exercise and dichloroacetate

28 September 2017

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Effects of lipid-lowering drugs on irisin in human subjects in vivo and in human skeletal muscle cells ex vivo

28 September 2017

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Ubiquinol rescues simvastatin-suppression of mitochondrial content, function and metabolism: implications for statin-induced rhabdomyolysis

28 September 2017

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28 September 2017

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AMP-activated protein kinase stimulates myostatin expression in C2C12 cells

28 September 2017

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AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity.

28 September 2017

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Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass

28 September 2017

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Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1.

28 September 2017

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Statin myopathy: a common dilemma not reflected in clinical trials

28 September 2017

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Statin‐associated myopathy and its exacerbation with exercise

28 September 2017

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Maternal creatine supplementation from mid-pregnancy protects the diaphragm of the newborn spiny mouse from intrapartum hypoxia-induced damage

28 September 2017

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Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo

28 September 2017

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Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447258

Smad2 and 3 transcription factors control muscle mass in adulthood.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447258

28 September 2017

Managing statin myopathy

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Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation

28 September 2017

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Molecular basis for statin-induced muscle toxicity: implications and possibilities

28 September 2017

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Statin suppresses apoptosis in osteoblastic cells: role of transforming growth factor-beta-Smad3 pathway

28 September 2017

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AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells

28 September 2017

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Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo

28 September 2017

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Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism

28 September 2017

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NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS.

28 September 2017

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The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis

28 September 2017

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PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

28 September 2017

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Toxicity of statins on rat skeletal muscle mitochondria

28 September 2017

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Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1.

28 September 2017

1 reference

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Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study

28 September 2017

1 reference

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Rho GTPases, statins, and nitric oxide

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447258

High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447258

The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447258

Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447258

Beyond lipid-lowering: effects of statins on endothelial nitric oxide

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447258

Statin-associated myopathy with normal creatine kinase levels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447258

Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447258

Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447258

Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447258

Atorvastatin and pitavastatin enhance lipoprotein lipase production in L6 skeletal muscle cells through activation of adenosine monophosphate-activated protein kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447258

Effect of nitric oxide synthase inhibition on mitochondrial biogenesis in rat skeletal muscle.

31 May 2018

1 reference

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Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt.

31 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Statin myotoxicity is associated with changes in the cardiopulmonary function

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Statin-induced muscle necrosis in the rat: distribution, development, and fibre selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Role of multi-drug resistance-associated protein-1 transporter in statin-induced myopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Simvastatin induces impairment in skeletal muscle while heart is protected.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Statins activate AMP-activated protein kinase in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Statin treatment and 3' polyadenylation of eNOS mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Atorvastatin upregulates nitric oxide synthases with Rho-kinase inhibition and Akt activation in the kidney of spontaneously hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0128398

Rosuvastatin: characterization of induced myopathy in the rat.

21 January 2018

1 reference

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Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin

28 November 2018

1 reference

12 December 2020

Mitochondrial alterations in muscle biopsies of patients on statin therapy

1 reference

12 December 2020

Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration

1 reference

12 December 2020

Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway

1 reference

12 December 2020

Neuronal NOS is dislocated during muscle atrophy in amyotrophic lateral sclerosis

1 reference

12 December 2020

Statins: established indications and controversial subgroups

1 reference

12 December 2020

Decreased skeletal muscle mitochondrial DNA in patients with statin-induced myopathy

1 reference

12 December 2020

Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0128398

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26020641%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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Fatcat

https://api.fatcat.wiki/v0/release/hzozcftx4fel3pctph5axvuyy4

24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26020641%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

26020641

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26020641%20AND%20SRC:MED&resulttype=core&format=json