Guarding the 'translation apparatus': defective ribosome biogenesis and the p53 signaling pathway (Q27022918)

The economics of ribosome biosynthesis in yeast

21 January 2018

1 reference

Regulation of ribosome biogenesis within the nucleolus

21 January 2018

1 reference

Pre-ribosomes on the road from the nucleolus to the cytoplasm

21 January 2018

1 reference

5 S rRNA: structure and interactions

21 January 2018

1 reference

Recent mechanistic insights into eukaryotic ribosomes

21 January 2018

1 reference

Maturation of eukaryotic ribosomes: acquisition of functionality

21 January 2018

1 reference

Growth control and ribosome biogenesis.

21 January 2018

1 reference

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

21 January 2018

1 reference

Nucleolus, ribosomes, and cancer

21 January 2018

1 reference

Does the ribosome translate cancer?

21 January 2018

1 reference

Ribosomopathies: human disorders of ribosome dysfunction

21 January 2018

1 reference

When ribosomes go bad: diseases of ribosome biogenesis

21 January 2018

1 reference

Ribosomes and marrow failure: coincidental association or molecular paradigm?

21 January 2018

1 reference

How common are extraribosomal functions of ribosomal proteins?

21 January 2018

1 reference

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway.

21 January 2018

1 reference

Live or let die: the cell's response to p53

21 January 2018

1 reference

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

21 January 2018

1 reference

Regulation and function of the p53-related proteins: same family, different rules

21 January 2018

1 reference

Blinded by the Light: The Growing Complexity of p53

21 January 2018

1 reference

21 January 2018

1 reference

Modulation of microRNA processing by p53

21 January 2018

1 reference

Regulation and function of the p53 tumor suppressor protein

21 January 2018

1 reference

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

21 January 2018

1 reference

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

21 January 2018

Surfing the p53 network

1 reference

Regulation of HDM2 activity by the ribosomal protein L11

21 January 2018

1 reference

Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

21 January 2018

1 reference

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

21 January 2018

1 reference

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

21 January 2018

1 reference

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

21 January 2018

1 reference

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

21 January 2018

1 reference

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

21 January 2018

1 reference

MDMX regulation of p53 response to ribosomal stress

21 January 2018

1 reference

Putting a finger on growth surveillance: insight into MDM2 zinc finger-ribosomal protein interactions.

21 January 2018

1 reference

Signaling to p53: ribosomal proteins find their way.

21 January 2018

1 reference

Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway

21 January 2018

1 reference

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

21 January 2018

1 reference

Ribosomal protein S7 is both a regulator and a substrate of MDM2

21 January 2018

1 reference

Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

21 January 2018

1 reference

Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26

21 January 2018

1 reference

Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain

21 January 2018

1 reference

Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation

21 January 2018

1 reference

The role of human ribosomal proteins in the maturation of rRNA and ribosome production

21 January 2018

1 reference

Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins

21 January 2018

1 reference

MYC as a regulator of ribosome biogenesis and protein synthesis

21 January 2018

1 reference

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

21 January 2018

1 reference

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

21 January 2018

1 reference

N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

21 January 2018

1 reference

Direct activation of RNA polymerase III transcription by c-Myc

21 January 2018

1 reference

MYC oncogenes and human neoplastic disease

21 January 2018

1 reference

Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product

21 January 2018

1 reference

Repression of RNA polymerase I transcription by the tumor suppressor p53

21 January 2018

1 reference

p53 is a general repressor of RNA polymerase III transcription

21 January 2018

1 reference

Overlapping functions of the pRb family in the regulation of rRNA synthesis

21 January 2018

1 reference

The retinoblastoma tumour suppressor in development and cancer

21 January 2018

1 reference

Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

21 January 2018

1 reference

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

21 January 2018

1 reference

Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization.

21 January 2018

1 reference

Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation

21 January 2018

1 reference

Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous system

21 January 2018

1 reference

The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway

21 January 2018

1 reference

WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development

21 January 2018

1 reference

Defects in 18 S or 28 S rRNA processing activate the p53 pathway

21 January 2018

1 reference

Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.

21 January 2018

1 reference

Depletion of the nucleolar protein nucleostemin causes G1 cell cycle arrest via the p53 pathway

21 January 2018

1 reference

Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2

21 January 2018

1 reference

Inhibition of c-Myc activity by ribosomal protein L11

21 January 2018

1 reference

Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response

21 January 2018

1 reference

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

21 January 2018

1 reference

Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation

21 January 2018

1 reference

Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response.

21 January 2018

1 reference

Silencing of ribosomal protein S9 elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation.

21 January 2018

1 reference

Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family

21 January 2018

1 reference

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

21 January 2018

1 reference

Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint

21 January 2018

1 reference

The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival.

21 January 2018

1 reference

The ribosomal protein genes and Minute loci of Drosophila melanogaster

21 January 2018

1 reference

Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway

21 January 2018

1 reference

Identification of 315 genes essential for early zebrafish development

21 January 2018

1 reference

Ribosomal protein gene knockdown causes developmental defects in zebrafish

21 January 2018

1 reference

Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish

21 January 2018

1 reference

Many ribosomal protein genes are cancer genes in zebrafish

21 January 2018

1 reference

Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia

21 January 2018

1 reference

Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute

21 January 2018

1 reference

Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29

21 January 2018

1 reference

Ribosomal proteins and colorectal cancer

21 January 2018

1 reference

A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice

21 January 2018

1 reference

Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita

21 January 2018

1 reference

Dyskeratosis Congenita: a historical perspective

21 January 2018

1 reference

Treacher Collins syndrome: current evaluation, treatment, and future directions

21 January 2018

1 reference

Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function.

21 January 2018

1 reference

The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia

21 January 2018

1 reference

Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients

21 January 2018

1 reference

Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia

21 January 2018

1 reference

Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia

21 January 2018

1 reference

Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia

21 January 2018

1 reference

Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia

21 January 2018

1 reference

Distinct haematological disorder with deletion of long arm of no. 5 chromosome

21 January 2018

1 reference

Patients with del(5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progression

21 January 2018

1 reference

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

21 January 2018

1 reference

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome

21 January 2018

1 reference

Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification

21 January 2018

1 reference

X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions

21 January 2018

1 reference

Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita

21 January 2018

1 reference

Telomere maintenance and human bone marrow failure

21 January 2018

1 reference

Novel dyskerin-mediated mechanism of p53 inactivation through defective mRNA translation

21 January 2018

1 reference

The Treacher Collins syndrome (TCOF1) gene product is involved in ribosomal DNA gene transcription by interacting with upstream binding factor

21 January 2018

1 reference

The Treacher Collins syndrome (TCOF1) gene product is involved in pre-rRNA methylation

21 January 2018

1 reference

Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities

21 January 2018

1 reference

Diamond Blackfan anemia 2008-2009: broadening the scope of ribosome biogenesis disorders

21 January 2018

1 reference

Diamond-Blackfan anemia: diagnosis, treatment, and molecular pathogenesis

21 January 2018

1 reference

Diamond-Blackfan anemia: a ribosomal puzzle

21 January 2018

1 reference

Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production

21 January 2018

1 reference

Mutation of ribosomal protein RPS24 in Diamond-Blackfan anemia results in a ribosome biogenesis disorder

21 January 2018

1 reference

Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits

21 January 2018

1 reference

Deficient RPS19 protein production induces cell cycle arrest in erythroid progenitor cells.

21 January 2018

1 reference

Ribosomal protein S19 deficiency leads to reduced proliferation and increased apoptosis but does not affect terminal erythroid differentiation in a cell line model of Diamond-Blackfan anemia.

21 January 2018

1 reference

Targeted disruption of the ribosomal protein S19 gene is lethal prior to implantation

21 January 2018

1 reference

Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype

21 January 2018

1 reference

Diamond Blackfan anemia: a disorder of red blood cell development

21 January 2018

1 reference

PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression

21 January 2018

1 reference

Repression of RNA polymerase III transcription by the retinoblastoma protein

21 January 2018

1 reference