Galectins and their ligands: negative regulators of anti-tumor immunity (Q27024580)

language of work or name

1 reference

December 2012

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published in

Glycoconjugate Journal

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1 reference

8-9

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page(s)

619-25

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Galectin-1 research in T cell immunity: past, present and future

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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

21 March 2017

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Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes

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Galectin-3 mediates post-ischemic tissue remodeling

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Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity.

21 March 2017

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Galectin-3--a jack-of-all-trades in cancer

28 September 2017

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28 September 2017

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Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress.

28 September 2017

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Peracetylated 4-fluoro-glucosamine reduces the content and repertoire of N- and O-glycans without direct incorporation.

28 September 2017

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Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

28 September 2017

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Viral induction and targeted inhibition of galectin-1 in EBV+ posttransplant lymphoproliferative disorders

28 September 2017

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Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

28 September 2017

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Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

28 September 2017

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Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients

28 September 2017

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A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumor-infiltrating lymphocytes and favors tumor rejection in mice

28 September 2017

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TIM-3 and its regulatory role in immune responses

28 September 2017

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Glioma-associated cancer-initiating cells induce immunosuppression

28 September 2017

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Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.

28 September 2017

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The costimulatory role of TIM molecules

28 September 2017

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The immunological potential of galectin-1 and -3.

28 September 2017

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Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells.

28 September 2017

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Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function

28 September 2017

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Tumor-associated galectin-3 modulates the function of tumor-reactive T cells

28 September 2017

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Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion

28 September 2017

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Structural features of galectin-9 and galectin-1 that determine distinct T cell death pathways

28 September 2017

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The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma

28 September 2017

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Galectin-1 expression in cancer-associated stromal cells correlates tumor invasiveness and tumor progression in breast cancer

28 September 2017

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Galectin-1: a small protein with major functions

28 September 2017

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Galectin-3: an open-ended story

28 September 2017

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Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death

28 September 2017

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Synthetic lactulose amines: novel class of anticancer agents that induce tumor-cell apoptosis and inhibit galectin-mediated homotypic cell aggregation and endothelial cell morphogenesis

28 September 2017

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Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells

28 September 2017

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Galectins as modulators of tumour progression

28 September 2017

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Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity

28 September 2017

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Mucins and mucin binding proteins in colorectal cancer

28 September 2017

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Expression of galectins in cancer: a critical review

28 September 2017

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Quaternary solution structures of galectins-1, -3, and -7.

28 September 2017

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The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death

28 September 2017

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Isolation and characterization of a novel eosinophil-specific galectin released into the lungs in response to allergen challenge

28 September 2017

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Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation

28 September 2017

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CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death

28 September 2017

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Ecalectin/galectin-9, a novel eosinophil chemoattractant: its function and production

28 September 2017

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Concentrations of galectin-3 in the sera of normal controls and cancer patients

28 September 2017

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Identification of the metastasis-associated, galactoside-binding lectin as a chimeric gene product with homology to an IgE-binding protein.

28 September 2017

1 reference

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Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression

28 September 2017

1 reference

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Inhibition of lectin-mediated ovarian tumor cell adhesion by sugar analogs

31 May 2018

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Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis

31 May 2018

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Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding

21 January 2018

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Dimeric galectin-1 binds with high affinity to alpha2,3-sialylated and non-sialylated terminal N-acetyllactosamine units on surface-bound extended glycans.

21 January 2018

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Apoptosis of T cells mediated by galectin-1.

21 January 2018

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Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting

21 January 2018

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Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege

21 January 2018

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Shuttling of galectin-3 between the nucleus and cytoplasm.

21 January 2018

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Loss of CD7, independent of galectin-3 expression, implies a worse prognosis in adult T-cell leukaemia/lymphoma.

21 January 2018

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CD4+CD7- leukemic T cells from patients with Sézary syndrome are protected from galectin-1-triggered T cell death.

21 January 2018

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Synthesis of stable and selective inhibitors of human galectins-1 and -3.

21 January 2018

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Strongly enhanced IL-10 production using stable galectin-1 homodimers

21 January 2018

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Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors

21 January 2018

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CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis

28 November 2018

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Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease

28 November 2018

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12 December 2020

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

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12 December 2020

Serum Galectin-1 and Galectin-3 Levels in Benign and Malignant Nodular Thyroid Disease

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12 December 2020

Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family

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12 December 2020

Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancer

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12 December 2020

[Serum galectin-9 in cervical cancer]

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12 December 2020

Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity

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12 December 2020

High expression of Galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer

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12 December 2020

The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide

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12 December 2020

Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments

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12 December 2020

10.1007/S10719-012-9379-0

Identifiers

DOI

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Dimensions Publication ID

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1 reference

PubMed publication ID

22544342

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