Three key proteases--angiotensin-I-converting enzyme (ACE), ACE2 and renin--within and beyond the renin-angiotensin system

12 December 2020

Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry

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12 December 2020

Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline

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12 December 2020

A new class of angiotensin-converting enzyme inhibitors

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12 December 2020

Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension.

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12 December 2020

Inhibition of human renin activity by saponins

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12 December 2020

Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms

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12 December 2020

Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters

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12 December 2020

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

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12 December 2020

Candesartan ameliorates cardiac dysfunction observed in angiotensin-converting enzyme 2-deficient mice

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12 December 2020

Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension

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12 December 2020

Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface

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12 December 2020

Angiotensin converting enzyme inhibitory peptides derived from food proteins: biochemistry, bioactivity and production

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12 December 2020

The two homologous domains of human angiotensin I-converting enzyme are both catalytically active

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12 December 2020

Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system

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12 December 2020

Isolation of human renin inhibitor from soybean: soyasaponin I is the novel human renin inhibitor in soybean

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12 December 2020

ACE2 activation promotes antithrombotic activity

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12 December 2020

Novel activity of human angiotensin I converting enzyme: release of the NH2- and COOH-terminal tripeptides from the luteinizing hormone-releasing hormone

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12 December 2020

Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability

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12 December 2020

Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats

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12 December 2020

Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).

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12 December 2020

Angiotensin-Converting Enzyme C-Terminal Catalytic Domain Is the Main Site of Angiotensin I Cleavage In Vivo

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12 December 2020

Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage

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12 December 2020

Plant food-derived Angiotensin I converting enzyme inhibitory peptides

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12 December 2020

Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design.

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12 December 2020

Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition

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12 December 2020

Kidney amino acid transport.

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12 December 2020

The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer's Abeta-(1-16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser [...]

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12 December 2020

Lactotripeptides do not lower ambulatory blood pressure in untreated whites: results from 2 controlled multicenter crossover studies

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12 December 2020

Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function.

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12 December 2020

Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.

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12 December 2020

Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene.

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12 December 2020

Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors

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12 December 2020

In vivo effect of the tetrapeptide, N-acetyl-Ser-Asp-Lys-Pro, on the G1-S transition of rat hepatocytes

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12 December 2020

The zinc metallopeptidase family: new faces, new functions

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12 December 2020

Physiology of kidney renin

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12 December 2020

Genetic Ace2 deficiency accentuates vascular inflammation and atherosclerosis in the ApoE knockout mouse.

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12 December 2020

Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats

1 reference

12 December 2020

RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis

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12 December 2020

ACE2, a promising therapeutic target for pulmonary hypertension

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12 December 2020

N-domain-specific substrate and C-domain inhibitors of angiotensin-converting enzyme: angiotensin-(1-7) and keto-ACE

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12 December 2020

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12 December 2020

Degradation of Met-enkephalin by hemolymph peptidases in Mytilus edulis

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12 December 2020

Renin, prorenin and the putative (pro)renin receptor

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12 December 2020

ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice.

1 reference

12 December 2020

Peptidase specificity characterization of C- and N-terminal catalytic sites of angiotensin I-converting enzyme.

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12 December 2020

Hydrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase

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12 December 2020

Secretase-mediated cell surface shedding of the angiotensin-converting enzyme

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12 December 2020

The synthetic tetrapeptide AcSDKP protects cells that reconstitute long-term bone marrow stromal cultures from the effects of mafosfamide (Asta Z 7654)

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12 December 2020

Physiology and pharmacology of the (pro)renin receptor

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12 December 2020

Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats

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12 December 2020

A map and new directions for the (pro)renin receptor in the brain: focus on "A role of the (pro)renin receptor in neuronal cell differentiation".

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12 December 2020

New class of agents for treatment of hypertension: Focus on direct renin inhibition

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12 December 2020

Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase

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12 December 2020

Renin-angiotensin system revisited

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12 December 2020

Genetic deletion of the angiotensin-(1-7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria

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12 December 2020

Prorenin and the (pro)renin receptor--an update

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12 December 2020

The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide.

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12 December 2020

Potentiation of bradykinin effect by angiotensin-converting enzyme inhibition does not correlate with angiotensin-converting enzyme activity in the rat mesenteric arteries

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12 December 2020

Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction

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12 December 2020

Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials

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12 December 2020

Identification and Inhibitory Properties of Multifunctional Peptides from Pea Protein Hydrolysate

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12 December 2020

Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.

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12 December 2020

Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin

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12 December 2020

The angiotensin converting enzyme (ACE).

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12 December 2020

Correlation of angiotensin-converting enzyme 2 gene polymorphisms with stage 2 hypertension in Han Chinese

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12 December 2020

Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity

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12 December 2020

Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor

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12 December 2020

Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade

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12 December 2020

The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling

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12 December 2020

A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

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12 December 2020

Evolutionary families of peptidases

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12 December 2020

Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men

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12 December 2020

The angiotensin-(1-7)/Mas receptor axis is expressed in sinoatrial node cells of rats.

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12 December 2020

Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system.

1 reference

12 December 2020

Angiotensin-I-converting enzyme and its relatives

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12 December 2020

Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease

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12 December 2020

The angiotensin-converting enzyme gene family: genomics and pharmacology

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12 December 2020

Major congenital malformations after first-trimester exposure to ACE inhibitors

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12 December 2020

Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases

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12 December 2020

Gene transfer of angiotensin-converting enzyme 2 in the nucleus tractus solitarius improves baroreceptor heart rate reflex in spontaneously hypertensive rats

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12 December 2020

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

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12 December 2020

The preparation and function of the hypertensin-converting enzyme

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12 December 2020

Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.

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12 December 2020

Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases

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12 December 2020

Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung

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12 December 2020

Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice

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12 December 2020

Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke

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12 December 2020

Molecular basis of exopeptidase activity in the C-terminal domain of human angiotensin I-converting enzyme: insights into the origins of its exopeptidase activity

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12 December 2020

The tetrapeptide AcSDKP, a negative regulator of cell cycle entry, inhibits the proliferation of human and chicken lymphocytes

1 reference

12 December 2020

Telmisartan, ramipril, or both in patients at high risk for vascular events

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12 December 2020

(Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats

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12 December 2020

ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis

1 reference

12 December 2020

The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme

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12 December 2020

Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren

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12 December 2020

Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis

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12 December 2020

Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis

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12 December 2020

Human prorenin has "gate and handle" regions for its non-proteolytic activation

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12 December 2020

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury

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12 December 2020

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

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12 December 2020

Prevention of myocardial fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in diabetic rats

1 reference

12 December 2020

The (pro)renin receptor: a new addition to the renin-angiotensin system?

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12 December 2020

Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides

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12 December 2020

The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380.

1 reference

12 December 2020

Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor

1 reference

12 December 2020

Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide

1 reference

12 December 2020

Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells.

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12 December 2020

Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation

1 reference

12 December 2020

The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo.

1 reference

12 December 2020

Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents

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12 December 2020

Structural requirements of Angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides

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12 December 2020

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

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12 December 2020

Crystal structure of the human angiotensin-converting enzyme-lisinopril complex

1 reference

12 December 2020

The occurrence of renin inhibitor in rice: isolation, identification, and structure-function relationship

1 reference

12 December 2020

Prorenin Induces Intracellular Signaling in Cardiomyocytes Independently of Angiotensin II

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12 December 2020

Novel activity of angiotensin-converting enzyme. Hydrolysis of cholecystokinin and gastrin analogues with release of the amidated C-terminal dipeptide

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12 December 2020

An ACE in the hole alternative pathways of the renin angiotensin system and their potential role in cardiac remodeling

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12 December 2020

Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63.

1 reference

12 December 2020

Ace revisited: a new target for structure-based drug design.

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12 December 2020

Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.

1 reference

12 December 2020