Role of osteocytes in multiple myeloma bone disease (Q26992195)

Current Opinion in Supportive and Palliative Care

published in

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407-13

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Apoptotic osteocytes and the control of targeted bone resorption

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21 March 2017

The amazing osteocyte

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Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

21 March 2017

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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

21 March 2017

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RANKL expression, function, and therapeutic targeting in multiple myeloma and chronic lymphocytic leukemia

21 March 2017

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Evidence for osteocyte regulation of bone homeostasis through RANKL expression

21 March 2017

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Matrix-embedded cells control osteoclast formation

21 March 2017

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Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

21 March 2017

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Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

21 March 2017

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Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation

21 March 2017

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

21 March 2017

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Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions

21 March 2017

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Bone marrow monocyte-/macrophage-derived activin A mediates the osteoclastogenic effect of IL-3 in multiple myeloma

28 September 2017

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Relationship between initial clinical presentation and the molecular cytogenetic classification of myeloma.

28 September 2017

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Osteocyte-driven bone remodeling

28 September 2017

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Osteocyte control of osteoclastogenesis

28 September 2017

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Myeloma cells suppress osteoblasts through sclerostin secretion

28 September 2017

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Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases

28 September 2017

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Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations

28 September 2017

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Sclerostin is overexpressed by plasma cells from multiple myeloma patients

28 September 2017

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Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation.

28 September 2017

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Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway

28 September 2017

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Apoptotic osteocytes regulate osteoclast precursor recruitment and differentiation in vitro

28 September 2017

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Novel actions of bisphosphonates in bone: Preservation of osteoblast and osteocyte viability

28 September 2017

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Thiazolidinediones induce osteocyte apoptosis and increase sclerostin expression

28 September 2017

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Targeting the bone microenvironment in multiple myeloma

28 September 2017

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A physical mechanism for coupling bone resorption and formation in adult human bone.

28 September 2017

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Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue

28 September 2017

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Metastases and multiple myeloma generate distinct transcriptional footprints in osteocytes in vivo

28 September 2017

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Remodeling and vascular spaces in bone

28 September 2017

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The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma

28 September 2017

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A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma.

28 September 2017

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Microdamage and apoptosis

28 September 2017

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Microcracks in cortical bone: how do they affect bone biology?

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

New insight in the mechanism of osteoclast activation and formation in multiple myeloma: focus on the receptor activator of NF-kappaB ligand (RANKL).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Pathogenesis of myeloma bone disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

RANK-Fc: a therapeutic antagonist for RANK-L in myeloma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Osteogenic inhibition in multiple myeloma.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

An open-label, phase 2 trial of denosumab in the treatment of relapsed or plateau-phase multiple myeloma

31 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

AML-1A and AML-1B regulation of MIP-1alpha expression in multiple myeloma.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation.

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Elevated circulating sclerostin correlates with advanced disease features and abnormal bone remodeling in symptomatic myeloma: reduction post-bortezomib monotherapy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Serum levels of total-RANKL in multiple myeloma.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Myeloma cell-induced disruption of bone remodelling compartments leads to osteolytic lesions and generation of osteoclast-myeloma hybrid cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Pathogenesis of myeloma bone disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278961

Bone marrow plasma macrophage inflammatory protein protein-1 alpha(MIP-1 alpha) and sclerostin in multiple myeloma: relationship with bone disease and clinical characteristics

28 November 2018

1 reference

12 December 2020

Excessive bone resorption in human plasmacytomas: direct induction by tumour cells in vivo

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12 December 2020

Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers

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12 December 2020

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

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12 December 2020

Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction

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12 December 2020

Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment

1 reference

12 December 2020

Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease

1 reference

12 December 2020

Upregulation of osteoblast apoptosis by malignant plasma cells: a role in myeloma bone disease

1 reference

12 December 2020

Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption

1 reference

12 December 2020

10.1097/SPC.0000000000000090

Identifiers

DOI

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1 reference

PubMed publication ID

25289928

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