Optimizing treatments for lymphangioleiomyomatosis (Q26865250)

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English	Optimizing treatments for lymphangioleiomyomatosis	scientific article

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instance of

scholarly article

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stated in

PubMed

title

Optimizing treatments for lymphangioleiomyomatosis (English)

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stated in

PubMed

author

Joel Moss

series ordinal

2

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author name string

Angelo M Taveira-DaSilva

series ordinal

1

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stated in

Crossref

language of work or name

English

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stated in

PubMed

publication date

June 2012

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stated in

PubMed

published in

Expert Review of Respiratory Medicine

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PubMed

volume

6

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PubMed

issue

3

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PubMed

page(s)

267-76

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PubMed

cites work

PI3K/AKT/mTOR Pathway in Angiogenesis

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Efficacy and safety of sirolimus in lymphangioleiomyomatosis

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21 March 2017

Cell cycle, CDKs and cancer: a changing paradigm

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21 March 2017

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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21 March 2017

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

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21 March 2017

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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21 March 2017

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

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21 March 2017

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

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21 March 2017

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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21 March 2017

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

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PubMed Central

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21 March 2017

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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PubMed Central

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21 March 2017

Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

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PubMed Central

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21 March 2017

The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners

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PubMed Central

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21 March 2017

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

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PubMed Central

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21 March 2017

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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PubMed Central

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21 March 2017

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

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PubMed Central

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21 March 2017

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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PubMed Central

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21 March 2017

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

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PubMed Central

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21 March 2017

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

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7 April 2017

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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PubMed Central

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7 April 2017

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

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PubMed Central

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7 April 2017

A current viewpoint of lymphangioleiomyomatosis supporting immunotherapeutic treatment options.

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PubMed Central

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28 September 2017

The role of autophagy in cancer: therapeutic implications

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28 September 2017

Changes in lung function and chylous effusions in patients with lymphangioleiomyomatosis treated with sirolimus

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PubMed Central

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28 September 2017

Is sirolimus a therapeutic option for patients with progressive pulmonary lymphangioleiomyomatosis?

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PubMed Central

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28 September 2017

Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis

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PubMed Central

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28 September 2017

mTORC2 is required for proliferation and survival of TSC2-null cells

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PubMed Central

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28 September 2017

Doxycycline inhibits matrix metalloproteinase-2 secretion from TSC2-null mouse embryonic fibroblasts and lymphangioleiomyomatosis cells.

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28 September 2017

Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

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28 September 2017

Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis

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28 September 2017

Phenotypic characterization of disseminated cells with TSC2 loss of heterozygosity in patients with lymphangioleiomyomatosis

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PubMed Central

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28 September 2017

Systematic review of aromatase inhibitors in the first-line treatment for hormone sensitive advanced or metastatic breast cancer

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28 September 2017

Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy

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28 September 2017

European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis

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28 September 2017

Feasibility of immunotherapy for lymphangioleiomyomatosis

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28 September 2017

Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells

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28 September 2017

Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies

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28 September 2017

Statins in lymphangioleiomyomatosis: a word of caution

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28 September 2017

Renal and liver tumors in Tsc2(+/-) mice, a model of tuberous sclerosis complex, do not respond to treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor

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28 September 2017

Serum vascular endothelial growth factor-D levels in patients with lymphangioleiomyomatosis reflect lymphatic involvement

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28 September 2017

Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models

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28 September 2017

Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells

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28 September 2017

mTOR and the control of whole body metabolism

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28 September 2017

Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells

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28 September 2017

PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects

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28 September 2017

Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene

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28 September 2017

Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin

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28 September 2017

Sirolimus amelioration of clinical symptoms of recurrent lymphangioleiomyomatosis after living-donor lobar lung transplantation

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28 September 2017

Lymphatic involvement in lymphangioleiomyomatosis

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28 September 2017

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

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28 September 2017

Tuberin, p27 and mTOR in different cells

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28 September 2017

Activation of the estrogen receptor contributes to the progression of pulmonary lymphangioleiomyomatosis via matrix metalloproteinase-induced cell invasiveness.

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28 September 2017

Diagnostic potential of serum VEGF-D for lymphangioleiomyomatosis.

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28 September 2017

Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis

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28 September 2017

Effect of a gonadotrophin-releasing hormone analogue on lung function in lymphangioleiomyomatosis.

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28 September 2017

TSC2 loss in lymphangioleiomyomatosis cells correlated with expression of CD44v6, a molecular determinant of metastasis

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28 September 2017

Pulmonary lymphangioleiomyomatosis (LAM): progress and current challenges

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28 September 2017

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

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28 September 2017

Sporadic lymphangioleiomyomatosis and tuberous sclerosis complex with lymphangioleiomyomatosis: comparison of CT features

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28 September 2017

Lymphatic endothelial cells, lymphangiogenesis, and extracellular matrix

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28 September 2017

The tuberous sclerosis genes and regulation of the cyclin-dependent kinase inhibitor p27.

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28 September 2017

Tissue-specific renin-angiotensin system in pulmonary lymphangioleiomyomatosis

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28 September 2017

The NHLBI lymphangioleiomyomatosis registry: characteristics of 230 patients at enrollment.

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28 September 2017

Interferon-gamma-Jak-Stat signaling in pulmonary lymphangioleiomyomatosis and renal angiomyolipoma: a potential therapeutic target

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28 September 2017

Molecular and genetic analysis of disseminated neoplastic cells in lymphangioleiomyomatosis.

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28 September 2017

Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of rapamycin-IFN-gamma treatment

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28 September 2017

Metastasis of benign tumor cells in tuberous sclerosis complex

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28 September 2017

Localized retroperitoneal lymphangioleiomyomatosis mimicking malignancy. A case report and review of the literature

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28 September 2017

Exacerbation of pulmonary lymphangioleiomyomatosis by exogenous oestrogen used for infertility treatment

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28 September 2017

Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism.

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PubMed Central

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28 September 2017

Lymphangioleiomyomatosis (LAM): a review of clinical and morphological features

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PubMed Central

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28 September 2017

Lymphangioleiomyomatosis: abdominopelvic CT and US findings

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28 September 2017

Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis

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28 September 2017

Frequent estrogen and progesterone receptor immunoreactivity in renal angiomyolipomas from women with pulmonary lymphangioleiomyomatosis

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28 September 2017

Pulmonary lymphangioleiomyomatosis. A study of 69 patients. Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P).

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429940

retrieved

28 September 2017

Evidence that lymphangiomyomatosis is caused by TSC2 mutations: chromosome 16p13 loss of heterozygosity in angiomyolipomas and lymph nodes from women with lymphangiomyomatosis

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429940

retrieved

28 September 2017

Hereditary cancer: two hits revisited

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429940

retrieved

28 September 2017

Pulmonary lymphangioleiomyomatosis and steroid receptors. An immunocytochemical study

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429940

retrieved

28 September 2017

Estrogen stimulation and tamoxifen inhibition of leiomyoma cell growth in vitro and in vivo

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429940

retrieved

28 September 2017

Control of p70 s6 kinase by kinase activity of FRAP in vivo

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429940

retrieved

31 May 2018

The tetracycline analogs minocycline and doxycycline inhibit angiogenesis in vitro by a non-metalloproteinase-dependent mechanism

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429940

retrieved

31 May 2018

Recurrence of lymphangioleiomyomatosis after single lung transplantation: new insights into pathogenesis.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Decline in lung function in patients with lymphangioleiomyomatosis treated with or without progesterone

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Evolution of pulmonary function after treatment with goserelin in patients with lymphangioleiomyomatosis

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Effects of rapamycin in the Eker rat model of tuberous sclerosis complex

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Sirolimus ameliorated post lung transplant chylothorax in lymphangioleiomyomatosis

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Vascular Endothelial Growth Factor-D Is Increased in Serum of Patients with Lymphangioleiomyomatosis

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Response of lymphangioleiomyomatosis to a mammalian target of rapamycin inhibitor (temsirolimus) -based treatment.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Effect of doxycycline on proliferation, MMP production, and adhesion in LAM-related cells

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Doxycycline treatment for lymphangioleiomyomatosis with urinary monitoring for MMPs.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Doxycycline use in patients with lymphangioleiomyomatosis: safety and efficacy in metalloproteinase blockade.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Pregnancy exacerbating unsuspected mediastinal lymphangioleiomyomatosis and chylothorax

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1586%2FERS.12.26

retrieved

21 January 2018

Atypical presentation of lymphangioleiomyomatosis as acute abdomen: CT diagnosis.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429940

retrieved

28 November 2018

Lymphangioleiomyomatosis: a complex tale of serum response factor-mediated tissue inhibitor of metalloproteinase-3 regulation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22788941

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sirolimus treatment for pulmonary lymphangioleiomyomatosis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22788941

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidemiology of tuberous sclerosis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22788941

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen and Progesterone Receptors in Lymphangioleiomyomatosis, Epithelioid Hemangioendothelioma, and Sclerosing Hemangioma of the Lung

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22788941

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphangioleiomyomatosis treatment with sirolimus

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22788941

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution and mRNA expression of insulin-like growth factor system in pulmonary lymphangioleiomyomatosis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22788941

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for activation of matrix metalloproteinases in the pathogenesis of pulmonary lymphangioleiomyomatosis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22788941

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphangiomyomatosis mimicking an abdominal lymphoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22788941

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1586/ERS.12.26

0 references

PMC publication ID

3429940

1 reference

stated in

PubMed

PubMed publication ID

22788941

1 reference

stated in

PubMed

ResearchGate publication ID

229080200

0 references

 

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