Pokeweed antiviral protein, a ribosome inactivating protein: activity, inhibition and prospects (Q26822931)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25635465%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

review article

1 reference

title

Pokeweed antiviral protein, a ribosome inactivating protein: activity, inhibition and prospects (English)

2 references

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29 February 2020

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28 September 2019

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20 December 2019

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29 February 2020

Dixie J Goss

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29 February 2020

language of work or name

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28 January 2015

4 references

28 September 2019

20 December 2019

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29 February 2020

4 references

28 September 2019

20 December 2019

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29 February 2020

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29 February 2020

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29 February 2020

page(s)

274-298

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Creative Commons Attribution

29 February 2020

2 references

28 September 2019

20 December 2019

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A novel interaction of pokeweed antiviral protein with translation initiation factors 4G and iso4G: a potential indirect mechanism to access viral RNAs

1 reference

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28 September 2017

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1 reference

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28 September 2017

1 reference

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28 September 2017

1 reference

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Homodimerization of pokeweed antiviral protein as a mechanism to limit depurination of pokeweed ribosomes

28 September 2017

1 reference

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Pokeweed antiviral protein depurinates the sarcin/ricin loop of the rRNA prior to binding of aminoacyl-tRNA to the ribosomal A-site

31 May 2018

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31 May 2018

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UK doctors warned after ricin poison found in police raid

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Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1.

31 May 2018

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31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Vascular leak syndrome: a side effect of immunotherapy

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Accumulating Evidence Suggests That Several AB-Toxins Subvert the Endoplasmic Reticulum-Associated Protein Degradation Pathway To Enter Target Cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

The plant translational apparatus

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Distribution and properties of major ribosome-inactivating proteins (28 S rRNA N-glycosidases) of the plant Saponaria officinalis L. (Caryophyllaceae).

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Isolation and characterization of a cDNA clone encoding the pokeweed antiviral protein II from Phytolacca americana and its expression in E. coli

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

ATP-dependent translocation of ricin across the membrane of purified endosomes.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Effective immunochemotherapy of human t(4;11) leukemia in mice with severe combined immunodeficiency (SCID) using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin plus cyclophosphamide

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Purification and partial characterization of another form of the antiviral protein from the seeds of Phytolacca americana L. (pokeweed).

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Inhibition by ricin of protein synthesis in vitro. Ribosomes as the target of the toxin

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

The effect of an antiviral peptide on the ribosomal reactions of the peptide elongation enzymes, EF-I and EF-II.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

The inhibition of infection by cucumber mosaic virus and influenza virus by extracts from Phytolacca americana

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Ribosome-inactivating proteins from plant cells in culture

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

High-pressure-liquid-chromatographic and fluorimetric methods for the determination of adenine released from ribosomes by ricin and gelonin

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

RNA pseudoknot domain of tobacco mosaic virus can functionally substitute for a poly(A) tail in plant and animal cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Ribosomal RNA identity elements for ricin A-chain recognition and catalysis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

A maize ribosome-inactivating protein is controlled by the transcriptional activator Opaque-2

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Some ribosome-inactivating proteins depurinate ribosomal RNA at multiple sites

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Developmental hierarchy during early human B-cell ontogeny after autologous bone marrow transplantation using autografts depleted of CD19+ B-cell precursors by an anti-CD19 pan-B-cell immunotoxin containing pokeweed antiviral protein

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Effective immunochemotherapy of CALLA+C mu+ human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19) pokeweed antiviral protein immunotoxin plus cyclophosphamide

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against BCL-1 murine B-cell leukemia

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Inhibition of protein synthesis by modeccin, the toxin of Modecca digitata

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Isolation and properties of abrin: a toxic protein inhibiting protein synthesis. Evidence for different biological functions of its two constituent-peptide chains.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Structure of a ricin mutant showing rescue of activity by a noncatalytic residue

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Activities associated with the presence of ribosome-inactivating proteins increase in senescent and stressed leaves.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

Enhanced quantitative resistance against fungal disease by combinatorial expression of different barley antifungal proteins in transgenic tobacco.

19 June 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Evidence for retro-translocation of pokeweed antiviral protein from endoplasmic reticulum into cytosol and separation of its activity on ribosomes from its activity on capped RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Adenine glycosylase activity in mammalian tissues: an equivalent of ribosome-inactivating proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Induction of a ribosome-inactivating protein upon environmental stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

First simultaneous isolation of a ribosome inactivating protein and an antifungal protein from a mushroom (Lyophyllum shimeji) together with evidence for synergism of their antifungal effects

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Hypsin, a novel thermostable ribosome-inactivating protein with antifungal and antiproliferative activities from fruiting bodies of the edible mushroom Hypsizigus marmoreus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Isolation and characterization of velutin, a novel low-molecular-weight ribosome-inactivating protein from winter mushroom (Flammulina velutipes) fruiting bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Isolation and enzymatic characterization of lamjapin, the first ribosome-inactivating protein from cryptogamic algal plant (Laminaria japonica A).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

cDNA cloning and expression of pokeweed antiviral protein from seeds in Escherichia coli and its inhibition of protein synthesis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

The Effect of Treating the Virus of Tobacco Mosaic With the Juices of Various Plants

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Effect of N-terminal deletions on the activity of pokeweed antiviral protein expressed in E. coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Isolation and characterization of a novel ribosome-inactivating protein from root cultures of pokeweed and its mechanism of secretion from roots

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Ricin A-chain inhibitors resembling the oxacarbenium ion transition state

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Pokeweed antiviral protein accesses ribosomes by binding to L3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Expression of a truncated form of ribosomal protein L3 confers resistance to pokeweed antiviral protein and the Fusarium mycotoxin deoxynivalenol

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Comparative analysis of depurination catalyzed by ricin A-chain on synthetic 32mer and 25mer oligoribonucleotides mimicking the sarcin/ricin domain of the rat 28S rRNA and E. coli 23S rRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Non-specific deadenylation and deguanylation of naked RNA catalyzed by ricin under acidic condition

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Deguanylation of human immunodeficiency virus (HIV-1) RNA by recombinant pokeweed antiviral protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Pokeweed antiviral protein inhibits brome mosaic virus replication in plant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Characterization of pokeweed antiviral protein binding to mRNA cap analogs: competition with nucleotides and enhancement by translation initiation factor iso4G.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

A non-toxic pokeweed antiviral protein mutant inhibits pathogen infection via a novel salicylic acid-independent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Translation Inhibition of Capped and Uncapped Viral RNAs Mediated by Ribosome-Inactivating Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

The role of the 3'-untranslated region of non-polyadenylated plant viral mRNAs in regulating translational efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

A novel recombinant vaccine which protects mice against ricin intoxication.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Interaction of genome-linked protein (VPg) of turnip mosaic virus with wheat germ translation initiation factors eIFiso4E and eIFiso4F.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

The 6K2 protein and the VPg of potato virus A are determinants of systemic infection in Nicandra physaloides

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Viral genome-linked protein (VPg) controls accumulation and phloem-loading of a potyvirus in inoculated potato leaves

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Central domain of a potyvirus VPg is involved in the interaction with the host translation initiation factor eIF4E and the viral protein HcPro

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

Characterization and molecular cloning of a proenzyme form of a ribosome-inactivating protein from maize. Novel mechanism of proenzyme activation by proteolytic removal of a 2.8-kilodalton internal peptide segment

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344624

28 November 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

The barley 60 kDa jasmonate-induced protein (JIP60) is a novel ribosome-inactivating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

N-acetyl-D-glucosamine-asparagine structure in ribosome-inactivating proteins from the seeds of Luffa cylindrica and Phytolacca americana

21 January 2018

1 reference

12 December 2020

Effect of crystalline ricin on the biosynthesis of protein, RNA, and DNA in experimental tumor cells

1 reference

12 December 2020

Purification and partial characterization of the antiviral protein from Phytolacca americana which inhibits eukaryotic protein synthesis

1 reference

12 December 2020

Ricin A chain can be chemically cross-linked to the mammalian ribosomal proteins L9 and L10e

1 reference

12 December 2020

Site-directed mutagenesis of ricin A-chain and implications for the mechanism of action

1 reference

12 December 2020

Pokeweed antiviral protein and its applications

1 reference

12 December 2020

In vivo toxicity, pharmacokinetics, and antileukemic activity of TXU (anti-CD7)-pokeweed antiviral protein immunotoxin

1 reference

12 December 2020

Production of a pokeweed antiviral protein (PAP)-containing immunotoxin, B43-PAP, directed against the CD19 human B lineage lymphoid differentiation antigen in highly purified form for human clinical trials

1 reference

12 December 2020

Inhibition of protein synthesis by Shiga toxin

1 reference

12 December 2020

Isolation and Characterization of a Type 1 Ribosome-Inactivating Protein from Fruiting Bodies of the Edible Mushroom (Volvariella volvacea)

1 reference

12 December 2020

Potyvirus genome-linked protein, VPg, directly affects wheat germ in vitro translation: interactions with translation initiation factors eIF4F and eIFiso4F

1 reference

12 December 2020

In vitro and in vivo cytotoxicity of an anti-osteosarcoma immunotoxin containing pokeweed antiviral protein

1 reference

12 December 2020

High-level expression and purification of biologically active recombinant pokeweed antiviral protein

1 reference

12 December 2020

Mouse monoclonal antibodies against Phytolacca americana antiviral protein PAP I

1 reference

12 December 2020

Purification and properties of new ribosome-inactivating proteins with RNA N-glycosidase activity.

1 reference

12 December 2020

1 reference

12 December 2020

Variations in the VPg Protein Allow a Potyvirus to OvercomevaGene Resistance in Tobacco

1 reference

12 December 2020

Advances in immunotoxin biology and therapy: a summary of the Fourth International Symposium on Immunotoxins

1 reference

12 December 2020

Pokeweed antiviral protein inactivates pokeweed ribosomes; implications for the antiviral mechanism

1 reference

12 December 2020

Replacement of the tyrosine residue that links a potyviral VPg to the viral RNA is lethal

1 reference

12 December 2020

Toxicity and cytotoxicity of nigrin b, a two-chain ribosome-inactivating protein from Sambucus nigra : comparison with ricin

1 reference

12 December 2020

Plant Lectins: A Composite of Several Distinct Families of Structurally and Evolutionary Related Proteins with Diverse Biological Roles

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

7 January 2021

inferred from DOI database lookup

FDA insists that oestrogen products for menopause carry a warning

1 reference

https://api.crossref.org/works/10.3390%2FTOXINS7020274

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.3390/TOXINS7020274

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25635465%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25635465%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

25635465

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25635465%20AND%20SRC:MED&resulttype=core&format=json