Pyruvate kinase: Function, regulation and role in cancer (Q26798084)

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English	Pyruvate kinase: Function, regulation and role in cancer	scientific article

Statements

instance of

scholarly article

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title

Pyruvate kinase: Function, regulation and role in cancer (English)

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main subject

cell biology

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author name string

William J Israelsen

series ordinal

1

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Matthew G Vander Heiden

series ordinal

2

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language of work or name

English

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publication date

July 2015

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published in

Seminars in Cell & Developmental Biology

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volume

43

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page(s)

43-51

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cites work

SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells

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PubMed Central

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Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase

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7 April 2017

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

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PubMed Central

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7 April 2017

Understanding the Warburg effect: the metabolic requirements of cell proliferation

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7 April 2017

Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme

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PubMed Central

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7 April 2017

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

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7 April 2017

Maximum activities of key enzymes of glycolysis, glutaminolysis, pentose phosphate pathway and tricarboxylic acid cycle in normal, neoplastic and suppressed cells

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7 April 2017

Isolation and characterization of the human pyruvate kinase M gene

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PubMed Central

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7 April 2017

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

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PubMed Central

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7 April 2017

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

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PubMed Central

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7 April 2017

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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PubMed Central

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7 April 2017

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

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PubMed Central

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7 April 2017

Pyruvate kinase M2 is a phosphotyrosine-binding protein

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PubMed Central

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7 April 2017

Structure of the bis(Mg2+)-ATP-oxalate complex of the rabbit muscle pyruvate kinase at 2.1 A resolution: ATP binding over a barrel

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7 April 2017

The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

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PubMed Central

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7 April 2017

The first step in sugar transport: crystal structure of the amino terminal domain of enzyme I of the E. coli PEP: sugar phosphotransferase system and a model of the phosphotransfer complex with HPr

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7 April 2017

On the Origin of Cancer Cells

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7 April 2017

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28 September 2017

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

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7 April 2017

Regulation of cancer cell metabolism

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PubMed Central

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7 April 2017

A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector Strength

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7 April 2017

The control of flux

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PubMed Central

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7 April 2017

The Pk-3 gene determines both the heart, M1, and the kidney, M2, pyruvate kinase isozymes in the mouse; and a simple electrophoretic method for separating phosphoglucomutase-3

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PubMed Central

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7 April 2017

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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PubMed Central

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7 April 2017

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

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PubMed Central

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7 April 2017

Lack of Evidence for PKM2 Protein Kinase Activity

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PubMed Central

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28 September 2017

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages

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PubMed Central

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28 September 2017

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation

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PubMed Central

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28 September 2017

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.

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PubMed Central

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28 September 2017

Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis

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28 September 2017

PKM2 regulates chromosome segregation and mitosis progression of tumor cells.

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PubMed Central

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28 September 2017

Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization

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PubMed Central

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28 September 2017

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

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PubMed Central

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28 September 2017

Pharmacologic activation of PKM2 slows lung tumor xenograft growth.

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PubMed Central

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28 September 2017

Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals

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PubMed Central

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28 September 2017

M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth

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PubMed Central

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28 September 2017

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

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PubMed Central

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28 September 2017

Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides

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PubMed Central

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28 September 2017

SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions

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PubMed Central

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28 September 2017

PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis

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PubMed Central

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28 September 2017

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

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PubMed Central

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28 September 2017

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

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PubMed Central

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28 September 2017

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

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28 September 2017

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

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PubMed Central

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28 September 2017

Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons

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PubMed Central

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28 September 2017

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

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28 September 2017

Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

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PubMed Central

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28 September 2017

Prolactin inhibits activity of pyruvate kinase M2 to stimulate cell proliferation

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PubMed Central

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28 September 2017

Evidence for an alternative glycolytic pathway in rapidly proliferating cells

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PubMed Central

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28 September 2017

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

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28 September 2017

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

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28 September 2017

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

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PubMed Central

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28 September 2017

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

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28 September 2017

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

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28 September 2017

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

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PubMed Central

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28 September 2017

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity

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28 September 2017

PHOSPHATE BOUND TO HISTIDINE IN A PROTEIN AS AN INTERMEDIATE IN A NOVEL PHOSPHO-TRANSFERASE SYSTEM

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28 September 2017

Pyruvate kinase type M2: a crossroad in the tumor metabolome

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28 September 2017

Metabolic characteristics of different malignant cancer cell lines.

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28 September 2017

Inhibition of human brain pyruvate kinase and hexokinase by phenylalanine and phenylpyruvate: possible relevance to phenylketonuric brain damage

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28 September 2017

Activation of liver pyruvate kinase by fructose 1,6-diphosphate

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28 September 2017

Phosphoenolpyruvate:carbohydrate phosphotransferase system of bacteria

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28 September 2017

Metabolite transfer via enzyme-enzyme complexes

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28 September 2017

Enzyme-enzyme interactions and the regulation of metabolic reaction pathways

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28 September 2017

The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing

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28 September 2017

Enolpyruvate: chemical determination as a pyruvate kinase intermediate

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28 September 2017

Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells.

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PubMed Central

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28 September 2017

Alanine-mediated reversible inactivation of tumour pyruvate kinase caused by a tetramer-dimer transition

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PubMed Central

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28 September 2017

Kinetic properties of pig pyruvate kinases type A from kidney and type M from muscle

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28 September 2017

Dual divalent cation requirement for activation of pyruvate kinase: essential roles of both enzyme- and nucleotide-bound metal ions

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28 September 2017

Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins

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PubMed Central

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31 May 2018

Observations on the carbohydrate metabolism of tumours

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31 May 2018

Crystallization, characterization and metabolic regulation of two types of pyruvate kinase isolated from rat tissues

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31 May 2018

A Linear Steady-State Treatment of Enzymatic Chains. Critique of the Crossover Theorem and a General Procedure to Identify Interaction Sites with an Effector

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31 May 2018

Bovine pyruvate kinases. II. Purification of the liver isozyme and its hybridization with skeletal muscle pyruvate kinase

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31 May 2018

A kinetic study of rabbit muscle pyruvate kinase

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31 May 2018

Kinetic and magnetic resonance studies of the interaction of oxalate with pyruvate kinase.

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31 May 2018

Multimolecular forms of pyruvate kinase from rat and other mammalian tissues. I. Electrophoretic studies

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

retrieved

31 May 2018

The structure of cat muscle pyruvate kinase

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

retrieved

31 May 2018

Domain interaction in rabbit muscle pyruvate kinase. I. Effects of ligands on protein denaturation induced by guanidine hydrochloride.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

retrieved

31 May 2018

On the evolutionary origins of the bacterial phosphoenolpyruvate:sugar phosphotransferase system

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

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31 May 2018

An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1,6-bisphosphate

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

retrieved

31 May 2018

Bovine pyruvate kinase isozymes and hybrid isozymes. Electrophoretic studies and tissue distribution

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

retrieved

31 May 2018

Pyruvate kinase isoenzymes in adult and fetal tissues of chicken

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

retrieved

31 May 2018

Three-dimensional structure of cat muscle pyruvate kinase at 3-1 A resolution

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

retrieved

31 May 2018

Mammalian pyruvate kinase hybrid isozymes: tissue distribution and physiological significance

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

retrieved

31 May 2018

Studies on associations of glycolytic and glutaminolytic enzymes in MCF-7 cells: role of P36.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

retrieved

31 May 2018

Differentiating a ligand's chemical requirements for allosteric interactions from those for protein binding. Phenylalanine inhibition of pyruvate kinase

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

retrieved

28 November 2018

Mutagenesis of the active site lysine 221 of the pyruvate kinase from Bacillus stearothermophilus

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

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28 November 2018

Proton donor in yeast pyruvate kinase: chemical and kinetic properties of the active site Thr 298 to Cys mutant

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

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28 November 2018

The proton transfer step catalyzed by yeast pyruvate kinase

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

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28 November 2018

Role of Lysine 240 in the Mechanism of Yeast Pyruvate Kinase Catalysis†

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

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28 November 2018

Structural and kinetic differences between the M2 type pyruvate kinases from lung and various tumors

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662905

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28 November 2018

Bovine pyruvate kinases. I. Purification and characterization of the skeletal muscle isozyme

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of precursor modulation of human pyruvate kinase I by fructose diphosphate

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multimolecular forms of pyruvate kinase. II. Purification of M 2 -type pyruvate kinase from Yoshida ascites hepatoma 130 cells and comparative studies on the enzymological and immunological properties of the three types of pyruvate kinases, L, M 1 ,

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of L-alanine and fructose (1, 6-diphosphate) on pyruvate kinase from ehrlich ascites tumour cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Kinetic Study of Nucleotide Interactions with Pyruvate Kinase*

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subunit Structure of Rabbit Muscle Pyruvate Kinase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle-associated expression of M2-type isozyme of pyruvate kinase in proliferating rat thymocytes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of structural alterations on the reactivity of the nucleotide substrate of rabbit muscle pyruvate kinase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate kinases from human erythrocytes and liver

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and properties of mouse pyruvate kinases K and M and of a modified K subunit

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A variation in mouse kidney pyruvate kinase activity determined by a mutant gene on chromosome 9

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate kinase isozymes from rat

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cold-sensitive cytosolic 3,5,3'-triiodo-L-thyronine-binding protein and pyruvate kinase from human erythrocytes share similar regulatory properties of hormone binding by glycolytic intermediates

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate kinase from bovine muscle and liver

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of chicken skeletal muscle pyruvate kinase and a proposal for its evolutionary relation to the other avian and mammalian isoenzymes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate kinase: modulation by L-phenylalanine and L-alanine

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteins associated with the soluble form of p36, the main target of the src oncogene product in chicken fibroblasts, are glycolytic enzymes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of Non-allosteric Pyruvate Kinase Isozyme into an Allosteric Enzyme by a Single Amino Acid Substitution

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of chicken pyruvate kinases by amino acids

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of Allosteric Activation of Yeast Pyruvate Kinase and Identification of Novel Effectors Using Computational Screening†

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic properties of pyruvate kinase hybrids formed with native type L and inactivated type M subunits

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric Properties of Skeletal Muscle Pyruvate Kinase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26277545

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycolysis—one of the keys to cancer?

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1016%2FJ.SEMCDB.2015.08.004

retrieved

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolic Channeling in Organized Enzyme Systems: Experiments and Models

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1016%2FJ.SEMCDB.2015.08.004

retrieved

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.SEMCDB.2015.08.004

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1044831

OpenCitations bibliographic resource ID

1044831

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1044831

PMC publication ID

4662905

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1044831

PubMed publication ID

26277545

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1044831

 

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