TREM2 in CNS homeostasis and neurodegenerative disease (Q26785919)

PubMed

31 July 2019

physiological phenomenon

1 reference

20 August 2019

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12 September 2019

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12 October 2019

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20 November 2019

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28 November 2019

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15 December 2019

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19 December 2019

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3 December 2020

1 reference

3 May 2021

Rosa Rademakers

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author name string

Meghan M Painter

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Yuka Atagi

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Chia-Chen Liu

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Huaxi Xu

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John D Fryer

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Guojun Bu

Molecular Neurodegeneration

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language of work or name

English

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publication date

4 September 2015

11 references

25 April 2019

31 July 2019

20 August 2019

12 September 2019

12 October 2019

20 November 2019

28 November 2019

15 December 2019

19 December 2019

3 December 2020

3 May 2021

11 references

25 April 2019

31 July 2019

20 August 2019

12 September 2019

12 October 2019

20 November 2019

28 November 2019

15 December 2019

19 December 2019

3 December 2020

3 May 2021

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Creative Commons Attribution 4.0 International

11 references

25 April 2019

31 July 2019

20 August 2019

12 September 2019

12 October 2019

20 November 2019

28 November 2019

15 December 2019

19 December 2019

3 December 2020

on focus list of Wikimedia project

3 May 2021

copyrighted

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ScienceSource

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cites work

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

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Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

7 April 2017

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A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

7 April 2017

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Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

7 April 2017

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Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

7 April 2017

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

7 April 2017

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R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

7 April 2017

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

7 April 2017

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7 April 2017

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Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

7 April 2017

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TREM2 and the neuroimmunology of Alzheimer's disease

7 April 2017

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Identification of a unique TGF-β-dependent molecular and functional signature in microglia

7 April 2017

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Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

7 April 2017

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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

7 April 2017

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Pattern recognition by TREM-2: binding of anionic ligands

7 April 2017

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

7 April 2017

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

7 April 2017

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Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

7 April 2017

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

7 April 2017

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

7 April 2017

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

7 April 2017

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More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk.

7 April 2017

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28 September 2017

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DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

28 September 2017

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TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

28 September 2017

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TREM2 is associated with increased risk for Alzheimer's disease in African Americans

28 September 2017

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

28 September 2017

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TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

28 September 2017

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Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.

28 September 2017

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Innate immunity in Alzheimer's disease

28 September 2017

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TREM2 R47H variant and risk of essential tremor: a cross-sectional international multicenter study

28 September 2017

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Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease

28 September 2017

1 reference

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

28 September 2017

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Homozygous TREM2 mutation in a family with atypical frontotemporal dementia

28 September 2017

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Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

28 September 2017

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TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

28 September 2017

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Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.

28 September 2017

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The microglial sensome revealed by direct RNA sequencing

28 September 2017

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Heterozygous TREM2 mutations in frontotemporal dementia

28 September 2017

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A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages

28 September 2017

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Insights into TREM2 biology by network analysis of human brain gene expression data

28 September 2017

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TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

28 September 2017

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CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

28 September 2017

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Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

28 September 2017

1 reference

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TREM2 is associated with the risk of Alzheimer's disease in Spanish population

28 September 2017

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Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

28 September 2017

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Microglial cell origin and phenotypes in health and disease

28 September 2017

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Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review

28 September 2017

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CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation.

28 September 2017

1 reference

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Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin

28 September 2017

1 reference

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Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors

28 September 2017

1 reference

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Meta-analysis of linkage studies for Alzheimer's disease--a web resource

28 September 2017

1 reference

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TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Activating and inhibitory functions of DAP12.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

TREMs in the immune system and beyond

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Heterogeneity of presenile dementia with bone cysts (Nasu-Hakola disease): three genetic forms.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

VAV proteins as signal integrators for multi-subunit immune-recognition receptors

28 September 2017

1 reference

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Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Nasu-Hakola syndrome: polycystic lipomembranous osteodysplasia with sclerosing leucoencephalopathy and presenile dementia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

TREM2 sustains microglial expansion during aging and response to demyelination

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Triggering receptor expressed on myeloid cells-2 fine-tunes inflammatory responses in murine Gram-negative sepsis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

A lipid metabolic disease-"membranous lipodystrophy"-an autopsy case demonstrating numerous peculiar membrane-structures composed of compound lipid in bone and bone marrow and various adipose tissues

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Neuropsychiatric and genetic aspects of a new hereditary disease characterized by progressive dementia and lipomembranous polycystic osteodysplasia

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4560063

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia

31 May 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13024-015-0040-9

Cutting Edge: TREM-2 Attenuates Macrophage Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13024-015-0040-9

Variant TREM2 as risk factor for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13024-015-0040-9

CSF-1R, DAP12 and beta-catenin: a ménage à trois.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13024-015-0040-9