TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson's disease (Q26747606)

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English	TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson's disease	scientific article

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instance of

scholarly article

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review article

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Europe PubMed Central

title

TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson's disease (English)

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main subject

nervous system development

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Parkinson's disease

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based on heuristic

inferred from title

author

Binukumar Bk

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stated in

ORCID Public Data File 2021

author name string

B K Binukumar

series ordinal

1

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Harish C Pant

series ordinal

2

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language of work or name

English

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publication date

May 2016

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published in

Neural Regeneration Research

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volume

11

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issue

5

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page(s)

698-701

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cites work

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Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease

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A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons

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Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

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7 April 2017

Peptide TFP5/TP5 derived from Cdk5 activator P35 provides neuroprotection in the MPTP model of Parkinson's disease

1 reference

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PubMed Central

reference URL

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28 September 2017

A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice

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A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation

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PubMed Central

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28 September 2017

Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5.

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28 September 2017

Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.

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28 September 2017

Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival

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28 September 2017

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

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28 September 2017

NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

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28 September 2017

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

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28 September 2017

Site-specific phosphorylation of Lys-Ser-Pro repeat peptides from neurofilament H by cyclin-dependent kinase 5: structural basis for substrate recognition

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28 September 2017

cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization

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28 September 2017

Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5

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PubMed Central

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31 May 2018

Epitopes located in spatially separate domains of each neurofilament subunit are present in parkinson's disease lewy bodies

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PubMed Central

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31 May 2018

Purification and characterization of a novel proline-directed protein kinase from bovine brain

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PubMed Central

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31 May 2018

Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments

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PubMed Central

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31 May 2018

Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.

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PubMed Central

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28 November 2018

Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson's disease

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PubMed Central

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28 November 2018

Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.

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PubMed Central

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28 November 2018

Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb

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PubMed Central

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28 November 2018

Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease

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PubMed Central

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28 November 2018

Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.

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PubMed Central

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28 November 2018

Topographic regulation of phosphorylation in giant neurons of the squid, Loligo pealei: role of phosphatases

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PubMed Central

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28 November 2018

A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904445

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28 November 2018

Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904445

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28 November 2018

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

1 reference

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PubMed Central

reference URL

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28 November 2018

Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M.

1 reference

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PubMed Central

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28 November 2018

p35 nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904445

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28 November 2018

Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/27335538

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12 December 2020

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Cyclin-dependent kinase-5 is associated with lipofuscin in motor neurones in amyotrophic lateral sclerosis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/27335538

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/27335538

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Principal neurofilament-associated protein kinase in squid axoplasm is related to casein kinase I

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/27335538

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P13suc1 associates with a cdc2-like kinase in a multimeric cytoskeletal complex in squid axoplasm

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/27335538

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.4103/1673-5374.182681

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1926633

OpenCitations bibliographic resource ID

1926633

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1926633

PMC publication ID

4904445

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1926633

PubMed publication ID

27335538

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1926633

 

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