The naturally trans-acting ribozyme RNase P RNA has leadzyme properties (Q24811172)

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English	The naturally trans-acting ribozyme RNase P RNA has leadzyme properties	scientific article

Statements

instance of

scholarly article

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title

The naturally trans-acting ribozyme RNase P RNA has leadzyme properties (English)

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main subject

ribozyme

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author name string

Ema Kikovska

series ordinal

1

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Nils-Egil Mikkelsen

series ordinal

2

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Leif A Kirsebom

series ordinal

3

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language of work or name

English

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publication date

2005

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published in

Nucleic Acids Research

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volume

33

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issue

21

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page(s)

6920-30

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cites work

Studies on Escherichia coli RNase P RNA with Zn2+ as the catalytic cofactor

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PubMed Central

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7 April 2017

Substrate discrimination in RNase P RNA-mediated cleavage: importance of the structural environment of the RNase P cleavage site

1 reference

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PubMed Central

reference URL

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7 April 2017

The Ribonuclease P Database

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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7 April 2017

Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates

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PubMed Central

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7 April 2017

Crystal structure of the leadzyme at 1.8 A resolution: metal ion binding and the implications for catalytic mechanism and allo site ion regulation

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stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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7 April 2017

Structure of an RNA dodecamer containing a fragment from SRP domain IV of Escherichia coli

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PubMed Central

reference URL

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7 April 2017

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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7 April 2017

Recent advances in the elucidation of the mechanisms of action of ribozymes

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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7 April 2017

Crystal structure of a bacterial ribonuclease P RNA.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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28 September 2017

Cross talk between the +73/294 interaction and the cleavage site in RNase P RNA mediated cleavage

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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28 September 2017

Recent insights into the structure and function of the ribonucleoprotein enzyme ribonuclease P.

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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28 September 2017

The chemical repertoire of natural ribozymes

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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28 September 2017

Metal ion cooperativity in ribozyme cleavage of RNA.

1 reference

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PubMed Central

reference URL

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28 September 2017

Monitoring the structure of Escherichia coli RNase P RNA in the presence of various divalent metal ions

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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28 September 2017

Ribonuclease P (RNase P) RNA is converted to a Cd(2+)-ribozyme by a single Rp-phosphorothioate modification in the precursor tRNA at the RNase P cleavage site

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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28 September 2017

The environment of two metal ions surrounding the splice site of a group I intron

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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28 September 2017

Different cleavage sites are aligned differently in the active site of M1 RNA, the catalytic subunit of Escherichia coli RNase P.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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28 September 2017

Lead cleavage sites in the core structure of group I intron-RNA

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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28 September 2017

Base pairing between Escherichia coli RNase P RNA and its substrate

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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28 September 2017

Nucleotide sequence and stability of the RNA component of RNase P from a temperature-sensitive mutant ofE. coli

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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28 September 2017

Minor components in transfer RNA: their characterization, location, and function.

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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28 September 2017

Functional domains of the RNA component of ribonuclease P revealed by chemical probing of mutant RNAs

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 September 2017

Site-specific cleavage by metal ion cofactors and inhibitors of M1 RNA, the catalytic subunit of RNase P from Escherichia coli

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 September 2017

A small metalloribozyme with a two-step mechanism

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 September 2017

Important 2'-hydroxyl groups in model substrates for M1 RNA, the catalytic RNA subunit of RNase P from Escherichia coli

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 September 2017

The kinetics and specificity of cleavage by RNase P is mainly dependent on the structure of the amino acid acceptor stem

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 September 2017

The P15-loop of Escherichia coli RNase P RNA is an autonomous divalent metal ion binding domain.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

30 May 2018

Mutations affecting two distinct functions of the RNA component of RNase P.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

30 May 2018

Ribonuclease P catalysis requires Mg2+ coordinated to the pro-RP oxygen of the scissile bond.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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30 May 2018

Residues in Escherichia coli RNase P RNA important for cleavage site selection and divalent metal ion binding.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

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30 May 2018

Metal ion requirements and other aspects of the reaction catalyzed by M1 RNA, the RNA subunit of ribonuclease P from Escherichia coli.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

19 June 2018

Complexity in orchestration of chemical groups near different cleavage sites in RNase P RNA mediated cleavage

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 November 2018

Analysis of solvent nucleophile isotope effects: evidence for concerted mechanisms and nucleophilic activation by metal coordination in nonenzymatic and ribozyme-catalyzed phosphodiester hydrolysis

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 November 2018

Catalysis by RNase P RNA: unique features and unprecedented active site plasticity

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 November 2018

The residue immediately upstream of the RNase P cleavage site is a positive determinant

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 November 2018

NMR spectroscopic evidence for Mn(2+)(Mg(2+)) binding to a precursor-tRNA microhelix near the potential RNase P cleavage site

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 November 2018

Interaction between Escherichia coli RNase P RNA and the discriminator base results in slow product release.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 November 2018

Pathway of Activation by Magnesium Ions of Substrates for the Catalytic Subunit of RNase P from Escherichia coli

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 November 2018

Cloning and characterization of the RNase P RNA genes from two porcine mycoplasmas

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1310964

retrieved

28 November 2018

Multiple magnesium ions in the ribonuclease P reaction mechanism

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16332695

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrolysis of DNA and RNA through cooperation of two metal ions: a novel mimic of phosphoesterases

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16332695

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leadzyme RNA catalysis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16332695

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of metal ions in the hydrolysis reaction catalyzed by RNase P RNA from Bacillus subtilis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16332695

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Manganese ions induce miscleavage in the Escherichia coli RNase P RNA-catalyzed reaction

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16332695

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of the RNA component of bacterial ribonuclease P

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16332695

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of the +73/294 interaction in Escherichia coli RNase P RNA substrate complexes for cleavage and metal ion coordination

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16332695

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/NAR/GKI993

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1026654

OpenCitations bibliographic resource ID

1026654

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1026654

PMC publication ID

1310964

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1026654

PubMed publication ID

16332695

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1026654

ResearchGate publication ID

7436325

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