A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death (Q24675372)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17161984%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

review article

1 reference

title

A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17161984%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

0 references

0 references

1 reference

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17161984%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

Tarek A Taha

1 reference

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23 December 2019

Thomas D Mullen

series ordinal

1 reference

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23 December 2019

language of work or name

English

0 references

publication date

1 November 2006

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Biochimica et Biophysica Acta

23 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17161984%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

volume

1758

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23 December 2019

issue

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23 December 2019

page(s)

2027-2036

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PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

23 December 2019

cites work

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Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1

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BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome

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14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax

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Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

7 April 2017

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The proapoptotic protein Bad binds the amphipathic groove of 14-3-3zeta

7 April 2017

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

7 April 2017

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Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis

7 April 2017

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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

7 April 2017

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Molecular cloning and functional characterization of murine sphingosine kinase

7 April 2017

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

7 April 2017

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Ceramide inactivates cellular protein kinase Calpha

7 April 2017

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Role of ceramide in cellular senescence

7 April 2017

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

7 April 2017

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7 April 2017

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7 April 2017

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Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.

28 September 2017

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28 September 2017

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Golgi fragmentation is associated with ceramide-induced cellular effects.

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Regulation of the apoptosis-necrosis switch

28 September 2017

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28 September 2017

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JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

28 September 2017

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28 September 2017

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Regulation of apoptosis by endoplasmic reticulum pathways.

28 September 2017

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28 September 2017

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Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells

28 September 2017

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28 September 2017

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28 September 2017

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TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes

28 September 2017

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28 September 2017

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Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells

28 September 2017

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28 September 2017

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Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

28 September 2017

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Human diploid fibroblasts that undergo a senescent-like differentiation have elevated ceramide and diacylglycerol

28 September 2017

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Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

28 September 2017

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Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells

28 September 2017

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Ceramide in the eukaryotic stress response

28 September 2017

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Apoptosis and cancer drug targeting

28 September 2017

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Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells

28 September 2017

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Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.

28 September 2017

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Suicidal tendencies: apoptotic cell death by caspase family proteinases

28 September 2017

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28 September 2017

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28 September 2017

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Analysis of bax protein in sphingosine-induced apoptosis in the human leukemic cell line TF1 and its bcl-2 transfectants.

28 September 2017

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An essential role for autophosphorylation in the dissociation of activated protein kinase C from the plasma membrane

28 September 2017

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Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M.

28 September 2017

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Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.

28 September 2017

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Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression

28 September 2017

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Bcl-2 phosphorylation required for anti-apoptosis function

28 September 2017

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Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis.

28 September 2017

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Bcl-2 interrupts the ceramide-mediated pathway of cell death.

28 September 2017

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1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells

28 September 2017

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Regulation of protein kinase C by sphingosine and lysosphingolipids

28 September 2017

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Functions of ceramide in coordinating cellular responses to stress

28 September 2017

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Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses

28 September 2017

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Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death

28 September 2017

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Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?

30 May 2018

1 reference

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Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis

30 May 2018

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Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells

30 May 2018

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Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling

30 May 2018

1 reference

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A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein

30 May 2018

1 reference

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Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction

30 May 2018

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Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells.

30 May 2018

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Sphingolipid second messengers: tumor suppressor lipids.

30 May 2018

1 reference

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Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

A central role for ceramide in the age-related acceleration of apoptosis in the female germline

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Positively charged ceramide is a potent inducer of mitochondrial permeabilization.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Ceramide induces release of pro-apoptotic proteins from mitochondria by either a Ca2+ -dependent or a Ca2+ -independent mechanism

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Sphingosine-dependent protein kinase-1, directed to 14-3-3, is identified as the kinase domain of protein kinase C delta

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Distinct apoptotic phenotypes induced by radiation and ceramide in both p53-wild-type and p53-mutated lymphoblastoid cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Activation of a p53-independent, sphingolipid-mediated cytolytic pathway in p53-negative mouse fibroblast cells treated with N-methyl-N-nitro-N-nitrosoguanidine

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Modification of ceramide metabolism increases cancer cell sensitivity to cytotoxics.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Inhibition of glycoprotein traffic through the secretory pathway by ceramide.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766198

Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells

28 November 2018

1 reference

12 December 2020

Regulation of cyclin-dependent kinase 2 activity by ceramide

1 reference

12 December 2020

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore

1 reference

12 December 2020

Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence

1 reference

12 December 2020

Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation

1 reference

12 December 2020

P53 mediates ceramide-induced apoptosis in SKN-SH cells

1 reference

12 December 2020

Tumor response to radiotherapy regulated by endothelial cell apoptosis

1 reference

12 December 2020

Ceramide inhibits phospholipase D in a cell-free system

1 reference

12 December 2020

cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons

1 reference

12 December 2020

Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide

1 reference

12 December 2020

A potential role for ceramide in the regulation of mouse epidermal keratinocyte proliferation and differentiation

1 reference

12 December 2020

Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide

1 reference

12 December 2020

Ceramide Induces CytochromecRelease from Isolated Mitochondria

1 reference

12 December 2020

Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A

1 reference

12 December 2020

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.BBAMEM.2006.10.018

7 January 2021

inferred from DOI database lookup

A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.BBAMEM.2006.10.018

7 January 2021

inferred from DOI database lookup

Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.BBAMEM.2006.10.018

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.BBAMEM.2006.10.018

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17161984%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17161984%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

PubMed publication ID

17161984

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17161984%20AND%20SRC:MED&resulttype=core&format=json