HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation (Q24669980)

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Daniel S Hwang

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Arumugam Premkumar

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Nathanael S Dayes

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Crafford Harris

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Scott A Wadsworth

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John J Siekierka

Structure--function relationships in HIV-1 Nef.

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language of work or name

English

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publication date

15 September 2005

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published in

Blood

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volume

106

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issue

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page(s)

2059-68

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cites work

1 reference

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Identification of the Nef-associated kinase as p21-activated kinase 2

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Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

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Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

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Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

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Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

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Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death

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NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope

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HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

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p21-activated kinase 1 plays a critical role in cellular activation by Nef.

28 September 2017

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Induction of activator protein 1 (AP-1) in macrophages by human immunodeficiency virus type-1 NEF is a cell-type-specific response that requires both hck and MAPK signaling events

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HIV-1 directly kills CD4+ T cells by a Fas-independent mechanism

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28 September 2017

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Apoptosis subversion: HIV-Nef provides both armor and sword

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Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

15928037

1 reference