Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2 (Q24651443)

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Dmitriy A Goncharov

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Matthew Spaits

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Daniel J Noonan

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Ekaterina Talovskaya

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Andrew Eszterhas

American Journal of Respiratory Cell and Molecular Biology

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language of work or name

English

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publication date

May 2006

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published in

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volume

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issue

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page(s)

561-72

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cites work

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Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs

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The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin

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TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

7 April 2017

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Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

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TSC2: filling the GAP in the mTOR signaling pathway

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Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis

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28 September 2017

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Multiple roles of the tuberous sclerosis complex genes

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis

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Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

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PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells

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12 December 2020

Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype--phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex

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12 December 2020

Lymphangioleiomyomatosis

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12 December 2020

Lymphangioleiomyomatosis: a review

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12 December 2020

A human airway smooth muscle cell line that retains physiological responsiveness

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12 December 2020