Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships (Q24655806)

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English	Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships	scientific article

Statements

instance of

scholarly article

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title

Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships (English)

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main subject

organic chemistry

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drug discovery

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opioid

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author name string

Peter L Katavic

series ordinal

1

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Kenneth Lamb

series ordinal

2

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Hernan Navarro

series ordinal

3

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Thomas E Prisinzano

series ordinal

4

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language of work or name

English

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publication date

August 2007

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published in

Journal of Natural Products

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volume

70

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issue

8

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page(s)

1278-82

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cites work

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Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats

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Effects of JDTic, a selective kappa-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model

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Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist

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Opioids and alcoholism

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Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.

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Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys

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Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans

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Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity

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Modulation of the behavioral and neurochemical effects of psychostimulants by kappa-opioid receptor systems.

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28 September 2017

Interactions between kappa opioid agonists and cocaine. Preclinical studies

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5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist

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Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys

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28 September 2017

Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine

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Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists

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28 September 2017

Endogenous opioid systems and alcohol addiction

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(±)-Diinsininone: made nature's way

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Chemical constituents from Amentotaxus yunnanensis and Torreyayunnanensis.

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Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system

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Hypericum perforatum inhibits the binding of mu- and kappa-opioid receptor expressed with the Semliki Forest virus system

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30 May 2018

Bimorphinans as highly selective, potent kappa opioid receptor antagonists

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A dose-ratio comparison of mu and kappa agonists in formalin and thermal pain

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28 November 2018

N-substituted 4beta-methyl-5-(3-hydroxyphenyl)-7alpha-amidomorphans are potent, selective kappa opioid receptor antagonists.

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Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro

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Hypericum perforatum CO2 Extract and Opioid Receptor Antagonists Act Synergistically to Reduce Ethanol Intake in Alcohol‐Preferring Rats

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In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs

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A remarkable change of opioid receptor selectivity on the attachment of a peptidomimetic kappa address element to the delta antagonist, natrindole: 5'-[N2-alkylamidino)methyl]naltrindole derivatives as a novel class of kappa opioid receptor antagoni

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Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17' basic group in the interaction with a putative address subsite on the kappa opioid receptor

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Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test

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Identifiers

DOI

10.1021/NP070194X

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PMC publication ID

2265593

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PubMed publication ID

17685652

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ResearchGate publication ID

6153217

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