Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation (Q24311887)

negative regulation of protein serine/threonine kinase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Hai Jiang

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Jianchun Wu

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Chen He

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Wending Yang

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Honglin Li

LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB

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language of work or name

English

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publication date

April 2009

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458-68

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cites work

1 reference

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

19 March 2017

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Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint

19 March 2017

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Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit

19 March 2017

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Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

19 March 2017

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Active cyclin B1-Cdk1 first appears on centrosomes in prophase

19 March 2017

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Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody

19 March 2017

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

19 March 2017

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Cloning of three novel neuronal Cdk5 activator binding proteins

19 March 2017

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

19 March 2017

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

19 March 2017

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cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

19 March 2017

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Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

19 March 2017

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The DNA damage response: putting checkpoints in perspective

19 March 2017

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Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

19 March 2017

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Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53

19 March 2017

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

19 March 2017

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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

19 March 2017

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Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

19 March 2017

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ATR disruption leads to chromosomal fragmentation and early embryonic lethality

19 March 2017

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Activation of Caspase-2 in Apoptosis

19 March 2017

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

19 March 2017

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Chk1 and Chk2 kinases in checkpoint control and cancer

22 April 2017

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Centrosomes in cellular regulation

7 April 2017

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Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe

27 September 2017

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Centrosome control of the cell cycle

27 September 2017

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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

27 September 2017

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Checking out the centrosome

27 September 2017

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G1 and S-phase checkpoints, chromosome instability, and cancer

27 September 2017

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Targeting the checkpoint kinases: chemosensitization versus chemoprotection

27 September 2017

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Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

27 September 2017

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Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1).

27 September 2017

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Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains

30 May 2018

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Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

30 May 2018

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Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

30 May 2018

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Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.

21 January 2018

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Initial steps of ferulic acid polymerization by lignin peroxidase

21 January 2018

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The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19223857