Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO (Q24310886)

oxidative single-stranded RNA demethylation

GO:0035513

1 reference

oxidative RNA demethylase activity

GO:0035553

1 reference

oxidative DNA demethylase activity

GO:0035515

1 reference

oxidative single-stranded DNA demethylation

GO:0035516

1 reference

oxidative DNA demethylation

GO:0035552

1 reference

AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase

1 reference

ChEBI release 2020-05-28

ChEBI ID

74732

1 reference

GOA release 2020-03-11

DNA demethylation

1 reference

Fat mass and obesity associated

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Guifang Jia

Guifang

Jia

1 reference

20 October 2023

Cai-Guang Yang

Cai-Guang

Yang

1 reference

20 October 2023

Shangdong Yang

Shangdong

Yang

1 reference

20 October 2023

Xing Jian

Xing

Jian

1 reference

20 October 2023

Chengqi Yi

Chengqi

1 reference

20 October 2023

Zhiqiang Zhou

Zhiqiang

Zhou

1 reference

20 October 2023

Chuan He

Chuan

1 reference

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA

20 October 2023

language of work or name

English

0 references

publication date

15 October 2008

0 references

published in

FEBS Letters

0 references

volume

582

0 references

issue

23-24

0 references

page(s)

3313-9

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Variation in FTO contributes to childhood obesity and severe adult obesity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Repair of methylation damage in DNA and RNA by mammalian AlkB homologues

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Expression and sub-cellular localization of human ABH family molecules

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Repair of alkylated DNA: recent advances

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Direct reversal of DNA alkylation damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Substrate specificities of bacterial and human AlkB proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Reversal of DNA alkylation damage by two human dioxygenases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

The FTO Gene, Implicated in Human Obesity, Is Found Only in Vertebrates and Marine Algae

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

The selectivity and inhibition of AlkB.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577709

Preparation and enzymatic hydrolysis of DNA and RNA for mass spectrometry

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/18775698

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.FEBSLET.2008.08.019

1 reference

release_a7r2faw2tvg7bjauq2rlrzwzje

Fatcat ID

0 references

1 reference

1 reference

1 reference