Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment (Q24319929)

Fas apoptotic inhibitory molecule 2

GOA release 2020-03-11

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Journal of Neurochemistry

GOA release 2020-03-11

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Miriam Fernández

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Carme Solé

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Miguel F Segura

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Joan X Comella

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Valentín Ceña

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Alicia Colino

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language of work or name

English

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publication date

October 2007

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published in

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volume

103

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issue

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page(s)

190-203

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cites work

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Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death

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Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and post-synaptic densities following transient global ischemia in the rat brain

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CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells.

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Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis

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Pathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiology

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Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation.

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Neural membrane protein 35/Lifeguard is localized at postsynaptic sites and in dendrites

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Fas and Fas Ligand are associated with neuritic degeneration in the AD brain and participate in β-amyloid-induced neuronal death

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GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival

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Control of neuronal branching by the death receptor CD95 (Fas/Apo-1).

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Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system

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7 January 2021

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

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7 January 2021

Fas—Beyond Death: A regenerative role for Fas in the nervous system

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7 January 2021

Fas engagement induces neurite growth through ERK activation and p35 upregulation

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7 January 2021

Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

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7 January 2021

Palmitoylation is required for efficient Fas cell death signaling

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7 January 2021

LFG: an anti-apoptotic gene that provides protection from Fas-mediated cell death

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7 January 2021

Multiple sclerosis: Fas signaling in oligodendrocyte cell death

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7 January 2021

Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species.

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7 January 2021

FasL (CD95L/APO-1L) resistance of neurons mediated by phosphatidylinositol 3-kinase-Akt/protein kinase B-dependent expression of lifeguard/neuronal membrane protein 35.

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7 January 2021

Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis.

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7 January 2021

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

1 reference

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7 January 2021