Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA) (Q24317848)

transcription coactivator activity

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

J L Riley

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S D Westerheide

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J A Price

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J A Brown

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J M Boss

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

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language of work or name

English

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publication date

May 1995

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533-43

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A new class of yeast transcriptional activators

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Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: evidence for transcriptional adaptors

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Alkaline phosphatase as a reporter enzyme

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Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction

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Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

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Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X.

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Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon

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A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes

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GAL4-VP16 is an unusually potent transcriptional activator

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Cloning of cDNAs for Fanconi's anaemia by functional complementation

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Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets

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Induction of murine peritoneal gamma/delta T cells and their role in resistance to bacterial infection

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Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA.

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7 January 2021

Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes.

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Two B cell factors bind the HLA-DRA X box region and recognize different subsets of HLA class II promoters

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7 January 2021

In vivo footprinting of MHC class II genes: bare promoters in the bare lymphocyte syndrome

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A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter

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Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.

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Mutational analysis of the DRA promoter: cis-acting sequences and trans-acting factors

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Stereospecific alignment of the X and Y elements is required for major histocompatibility complex class II DRA promoter function

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The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters

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Functional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX.

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Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet

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Sequences and factors: a guide to MHC class-II transcription

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