Cell cycle, CDKs and cancer: a changing paradigm (Q24314465)

GOA release 2020-03-11

meiosis

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To cycle or not to cycle: a critical decision in cancer.

GOA release 2020-03-11

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Marcos Malumbres

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language of work or name

English

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publication date

March 2009

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published in

Nature Reviews Cancer

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volume

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issue

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page(s)

153-66

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cites work

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G1 cell-cycle control and cancer

31 March 2020

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Cell-cycle checkpoints and cancer

31 March 2020

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On the road to cancer: aneuploidy and the mitotic checkpoint

31 March 2020

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Mammalian cyclin-dependent kinases

31 March 2020

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Checking on DNA damage in S phase

31 March 2020

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A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy

31 March 2020

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The spindle-assembly checkpoint in space and time

31 March 2020

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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

31 March 2020

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Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

31 March 2020

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Distinct roles for cyclin-dependent kinases in cell cycle control

31 March 2020

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Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts

31 March 2020

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Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

31 March 2020

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

31 March 2020

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Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

31 March 2020

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Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

31 March 2020

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Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

31 March 2020

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Cdk2 knockout mice are viable

31 March 2020

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Cdk1 is sufficient to drive the mammalian cell cycle

31 March 2020

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Mice thrive without Cdk4 and Cdk2.

31 March 2020

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Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation

31 March 2020

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Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2

31 March 2020

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Cell cycle in mouse development

31 March 2020

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Mouse development and cell proliferation in the absence of D-cyclins.

31 March 2020

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Cyclin E ablation in the mouse

31 March 2020

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Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells

31 March 2020

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Kinase-independent function of cyclin E

31 March 2020

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Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

31 March 2020

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Delayed early embryonic lethality following disruption of the murine cyclin A2 gene.

31 March 2020

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Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero

31 March 2020

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p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity

31 March 2020

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Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

31 March 2020

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shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development

31 March 2020

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p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus

31 March 2020

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Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

31 March 2020

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Hematopoietic stem cell quiescence maintained by p21cip1/waf1

31 March 2020

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Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

31 March 2020

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In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C.

31 March 2020

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Hematopoietic stem cell exhaustion impacted by p18 INK4C and p21 Cip1/Waf1 in opposite manners

31 March 2020

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Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

31 March 2020

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p16INK4a induces an age-dependent decline in islet regenerative potential

31 March 2020

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p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers

31 March 2020

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

31 March 2020

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Loss of the tumor suppressor p15Ink4b enhances myeloid progenitor formation from common myeloid progenitors.

31 March 2020

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Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.

31 March 2020

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NFATc1 balances quiescence and proliferation of skin stem cells

31 March 2020

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Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone

31 March 2020

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Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.

31 March 2020

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Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence

31 March 2020

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Invasive melanoma in Cdk4-targeted mice

31 March 2020

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Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1).

31 March 2020

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Cdc2-cyclin E complexes regulate the G1/S phase transition

31 March 2020

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Proliferation of cancer cells despite CDK2 inhibition.

31 March 2020

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Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues

31 March 2020

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Requirement for CDK4 kinase function in breast cancer

31 March 2020

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Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis

31 March 2020

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Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis

31 March 2020

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Specific protection against breast cancers by cyclin D1 ablation

31 March 2020

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Is Cyclin D1-CDK4 kinase a bona fide cancer target?

31 March 2020

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Genome instability: a mechanistic view of its causes and consequences

31 March 2020

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ATR: an essential regulator of genome integrity

31 March 2020

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Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

31 March 2020

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Single-strand break repair and genetic disease

31 March 2020

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CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

31 March 2020

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

31 March 2020

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

31 March 2020

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

31 March 2020

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

31 March 2020

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An oncogene-induced DNA damage model for cancer development

31 March 2020

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Dual role of CDKs in DNA repair: to be, or not to be.

31 March 2020

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CDK targets Sae2 to control DNA-end resection and homologous recombination

31 March 2020

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CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

31 March 2020

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The reversibility of mitotic exit in vertebrate cells

31 March 2020

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Cdk-counteracting phosphatases unlock mitotic exit

31 March 2020

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The anaphase promoting complex/cyclosome: a machine designed to destroy

31 March 2020

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Finishing mitosis, one step at a time.

31 March 2020

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Ubiquitin ligases: cell-cycle control and cancer

31 March 2020

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Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

31 March 2020

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Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

31 March 2020

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A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

31 March 2020

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Oncogenes and tumour suppressors take on centrosomes

31 March 2020

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Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

31 March 2020

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Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells

31 March 2020

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An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells

31 March 2020

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Patterns of somatic mutation in human cancer genomes

31 March 2020

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Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

31 March 2020

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Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability

31 March 2020

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Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

31 March 2020

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

31 March 2020

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Bub1 maintains centromeric cohesion by activation of the spindle checkpoint

31 March 2020

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Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency

31 March 2020

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MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

31 March 2020

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

31 March 2020

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Aneuploidy: instigator and inhibitor of tumorigenesis

31 March 2020

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31 March 2020

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The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells.

31 March 2020

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Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

31 March 2020

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The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory

31 March 2020

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Aurora-kinase inhibitors as anticancer agents

31 March 2020

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Cell cycle kinases in cancer

31 March 2020

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Emerging cancer therapeutic opportunities by inhibiting mitotic kinases

31 March 2020

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Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.

31 March 2020

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Targeting polo-like kinase 1 for cancer therapy.

31 March 2020

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Polo and Aurora kinases: lessons derived from chemical biology

31 March 2020

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CDK inhibitors in cancer therapy: what is next?

31 March 2020

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Cyclin-dependent kinase pathways as targets for cancer treatment

31 March 2020

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Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.

31 March 2020

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Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development

31 March 2020

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Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer

31 March 2020

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Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice

31 March 2020

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Aneuploidy acts both oncogenically and as a tumor suppressor

31 March 2020

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

31 March 2020

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Pho85, a multifunctional cyclin-dependent protein kinase in budding yeast

31 March 2020

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CDK activation by non-cyclin proteins

31 March 2020

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Multiple levels of cyclin specificity in cell-cycle control

31 March 2020

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Cyclin C/cdk3 promotes Rb-dependent G0 exit

31 March 2020

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Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons

31 March 2020

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Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity

31 March 2020

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Secrets of a double agent: CDK7 in cell-cycle control and transcription

31 March 2020

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Role of CDK/cyclin complexes in transcription and RNA splicing

31 March 2020

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

31 March 2020

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E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

31 March 2020

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14-3-3sigma controls mitotic translation to facilitate cytokinesis

31 March 2020

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Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate

31 March 2020

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CDK11(p58) is required for the maintenance of sister chromatid cohesion

31 March 2020

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Synchronicity: policing multiple aspects of gene expression by Ctk1

31 March 2020

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Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation

31 March 2020

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CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing

31 March 2020

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Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number

31 March 2020

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Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice

31 March 2020

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Cdk4 is indispensable for postnatal proliferation of the anterior pituitary.

31 March 2020

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Pituitary Hypoplasia and Lactotroph Dysfunction in Mice Deficient for Cyclin-Dependent Kinase-4

31 March 2020

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Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity

31 March 2020

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Genetic control of the cell-division cycle in yeast. I. Detection of mutants

31 March 2020

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Genetic control of cell size at cell division in yeast

31 March 2020

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Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

31 March 2020

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Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

31 March 2020

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The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

31 March 2020

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The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

31 March 2020

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Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

31 March 2020

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31 March 2020

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Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

31 March 2020

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Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

31 March 2020

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Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

31 March 2020

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

31 March 2020

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Wild-type p53 activates transcription in vitro

31 March 2020

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Regulation of the specific DNA binding function of p53

31 March 2020

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Ras-induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

31 March 2020

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Cancer. p53, guardian of the genome

31 March 2020

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Wild-type p53 is a cell cycle checkpoint determinant following irradiation

31 March 2020

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

31 March 2020

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Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation

31 March 2020

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

31 March 2020

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p21 is a universal inhibitor of cyclin kinases

31 March 2020

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

31 March 2020

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p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

31 March 2020

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Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

31 March 2020

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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

31 March 2020

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

31 March 2020

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Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution

31 March 2020

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p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene

31 March 2020

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Identification of a human mitotic checkpoint gene: hsMAD2

31 March 2020

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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

31 March 2020

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Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

31 March 2020

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

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Mutations of mitotic checkpoint genes in human cancers

31 March 2020

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

31 March 2020

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Tumour biology: senescence in premalignant tumours

31 March 2020

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Oncogene-induced senescence as an initial barrier in lymphoma development

31 March 2020

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

31 March 2020

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Cyclin D-dependent kinases, INK4 inhibitors and cancer

31 March 2020

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12 December 2020

Pituitary hypoplasia and lactotroph dysfunction in mice deficient for cyclin-dependent kinase-4.

1 reference

12 December 2020

A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene

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12 December 2020

The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation

1 reference

12 December 2020

Control of G2 delay by the rad9 gene of Saccharomyces cerevisiae

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12 December 2020

Identifiers

DOI

10.1038/NRC2602

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1008867916

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Fatcat ID

release_tg767drmijcqvbhlecpmgaqsee

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tg767drmijcqvbhlecpmgaqsee

24 November 2022

mapped directly with Wikidata item

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

19238148

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Consolidated OpenCitations Corpus – April 2017