Proapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinase (Q24307641)

positive regulation of neuron apoptotic process

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Brendan Bingham

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Ru Shen

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Smita Kotnis

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C Frederick Lo

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Bradley A Ozenberger

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Nivedita Ghosh

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Jeffrey D Kennedy

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J Steven Jacobsen

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Jill M Grenier

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Peter S DiStefano

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Lillian W Chiang

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Andrew Wood

The Kex2p proregion is essential for the biosynthesis of an active enzyme and requires a C-terminal basic residue for its function

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language of work or name

English

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publication date

1 November 2006

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1123-31

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cites work

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To die or not to die: an overview of apoptosis and its role in disease.

21 January 2018

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Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

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Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat cerebellar granule cells

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The role of inducible transcription factors in apoptotic nerve cell death

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An orchestrated gene expression component of neuronal programmed cell death revealed by cDNA array analysis.

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7 January 2021

Functional characterization of Narc 1, a novel proteinase related to proteinase K

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

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Effect of mutations in the PCSK9 gene on the cell surface LDL receptors

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Genetic variants in PCSK9 affect the cholesterol level in Japanese

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A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree

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Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia

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7 January 2021

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

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7 January 2021

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

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7 January 2021

Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

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7 January 2021

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

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7 January 2021

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

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Laser scanning cytometry in the characterization of the proapoptotic effects of transiently transfected genes in cerebellar granule neurons

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7 January 2021

Laser-scanning cytometry: A new instrumentation with many applications

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Protease variants, LDL, and coronary heart disease

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A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

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7 January 2021

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

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7 January 2021

Expression and localization of PCSK9 in rat hepatic cells

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Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity

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Caspase-independent cell death

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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Caspase-dependent and -independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxin treatment.

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Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death

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Inhibitors of proprotein convertases

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No genetic association between PCSK9 polymorphisms and Alzheimer's disease and plasma cholesterol level in Japanese patients

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7 January 2021