A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads (Q24304169)

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Language	Label	Description	Also known as
English	A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads	scientific article

Statements

scholarly article

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A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads (English)

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Signal recognition particle 72

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GOA release 2020-03-11

Signal recognition particle 54

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GOA release 2020-03-11

Signal recognition particle 68

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GOA release 2020-03-11

Signal recognition particle 19

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GOA release 2020-03-11

Signal recognition particle 14

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GOA release 2020-03-11

response to drug

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GOA release 2020-03-11

author name string

Makoto Yoshida

1

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Yasuaki Kabe

2

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Tadashi Wada

3

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Akira Asai

4

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Hiroshi Handa

5

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language of work or name

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publication date

March 2008

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Molecular Pharmacology

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73

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3

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987-94

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Combination effects of TAS-103, a novel dual topoisomerase I and II inhibitor, with other anticancer agents on human small cell lung cancer cells

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Biochemical basis for the interactions of type I and type II topoisomerases with DNA.

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Selective ligand purification using high-performance affinity beads.

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Inefficient targeting to the endoplasmic reticulum by the signal recognition particle elicits selective defects in post-ER membrane trafficking

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Simultaneous determination of a novel anticancer drug, TAS-103, and its N-demethylated metabolite in monkey plasma by high-performance liquid chromatography using solid-phase extraction

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Total analysis and purification of cellular proteins binding to cisplatin-damaged DNA using submicron beads

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Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.

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DNA topoisomerases as targets for the anticancer drug TAS-103: primary cellular target and DNA cleavage enhancement

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DNA topoisomerases as targets for the anticancer drug TAS-103: DNA interactions and topoisomerase catalytic inhibition

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High-performance affinity beads for identifying drug receptors

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Regulation of interaction of the acetyltransferase region of p300 and the DNA-binding domain of Sp1 on and through DNA binding.

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Mechanism of H-8 inhibition of cyclin-dependent kinase 9: study using inhibitor-immobilized matrices

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Signal recognition particle components in the nucleolus

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p300 collaborates with Sp1 and Sp3 in p21(waf1/cip1) promoter activation induced by histone deacetylase inhibitor

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DNA topoisomerase II poison TAS-103 transactivates GC-box-dependent transcription via acetylation of Sp1.

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Assembly of the 68- and 72-kD proteins of signal recognition particle with 7S RNA

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The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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SRPDB: Signal Recognition Particle Database

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Interaction of a novel antitumor agent TAS-103 with DNA.

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DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

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Antitumor Activity of a Novel Quinoline Derivative, TAS‐103, with Inhibitory Effects on Topoisomerases I and II

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Signal recognition particle (SRP), a ubiquitous initiator of protein translocation

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A new mechanism of methotrexate action revealed by target screening with affinity beads

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DNA topoisomerases

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The signal recognition particle

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Getting on target: the archaeal signal recognition particle

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Identifiers

10.1124/MOL.107.043307

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