PDK1, the master regulator of AGC kinase signal transduction (Q24297416)

protein autophosphorylation

GOA release 2020-03-11

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GOA release 2020-03-11

David Komander

David

Komander

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9 December 2023

Alfonso Mora

Alfonso

Mora

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9 December 2023

Dario R Alessi

Dario R

Alessi

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9 December 2023

Daan M F van Aalten

Daan M F

van Aalten

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15209375

Seminars in Cell & Developmental Biology

9 December 2023

language of work or name

English

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publication date

April 2004

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published in

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volume

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issue

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page(s)

161-70

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cites work

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Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms.

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Role of S6 phosphorylation and S6 kinase in cell growth

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The conformational plasticity of protein kinases

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Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.

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PTEN: The down side of PI 3-kinase signalling.

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

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Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

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Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

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7 January 2021

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Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

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TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

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Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

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Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

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Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

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Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

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Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

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Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

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Partial purification and characterization of a wortmannin-sensitive and insulin-stimulated protein kinase that activates heart 6-phosphofructo-2-kinase

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

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Monitoring conformational changes of proteins in cells by fluorescence lifetime imaging microscopy

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Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

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Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

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Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

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Mechanisms of control of heart glycolysis

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7 January 2021

PDK1 regulates growth through Akt and S6K in Drosophila

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Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway.

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7 January 2021

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

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Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

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Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

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Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

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Role of translocation in the activation and function of protein kinase B

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7 January 2021

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

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7 January 2021

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

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7 January 2021

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

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7 January 2021

Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop

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7 January 2021

Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes

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7 January 2021

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

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7 January 2021

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

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7 January 2021

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

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7 January 2021

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

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7 January 2021

Essential role of PDK1 in regulating cell size and development in mice

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High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

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7 January 2021

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

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7 January 2021

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

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7 January 2021

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

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7 January 2021

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

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7 January 2021

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

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7 January 2021

Phosphorylation and activation of p70s6k by PDK1

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7 January 2021

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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7 January 2021

The phosphoinositide 3-kinase pathway

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7 January 2021

Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms

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7 January 2021

Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

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7 January 2021

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

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The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01.

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7 January 2021