Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function (Q113000684)

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An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9701193)

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Language	Label	Description	Also known as
English	Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9701193)

Statements

instance of

biological pathway

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

part of

Diseases of DNA Double-Strand Break Repair

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

found in taxon

Homo sapiens

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

exact match

https://identifiers.org/reactome:R-HSA-9701193

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

has part(s)

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

cites work

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

1 reference

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Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

Penetrance analysis of the PALB2 c.1592delT founder mutation

1 reference

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Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

Molecular Mechanisms of PALB2 Function and Its Role in Breast Cancer Management

1 reference

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Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

1 reference

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Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

PALB2: the hub of a network of tumor suppressors involved in DNA damage responses

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

PALB2/FANCN: Recombining Cancer and Fanconi Anemia

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

Breast-Cancer Risk in Families with Mutations in PALB2

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

Exploring the roles of PALB2 at the crossroads of DNA repair and cancer.

1 reference

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Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

The Tumor Suppressor PALB2: Inside Out

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Reactome

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8 July 2022

Reactome ID

R-HSA-9701193

Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families

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Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

PALB2 self-interaction controls homologous recombination

1 reference

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Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

The Role of PALB2 in the DNA Damage Response and Cancer Predisposition.

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

A recurrent mutation in PALB2 in Finnish cancer families.

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

PALB2 Variants: Protein Domains and Cancer Susceptibility

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

Identifiers

Reactome ID

R-HSA-9701193

1 reference

stated in

Reactome

retrieved

8 July 2022

Reactome ID

R-HSA-9701193

 

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