MutL homolog 1 (Q14911713)

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mammalian protein found in Mus musculus
  • DNA mismatch repair protein Mlh1
  • mutL protein homolog 1
  • colon cancer, nonpolyposis type 2
  • Mlh1
edit
Language Label Description Also known as
English
MutL homolog 1
mammalian protein found in Mus musculus
  • DNA mismatch repair protein Mlh1
  • mutL protein homolog 1
  • colon cancer, nonpolyposis type 2
  • Mlh1

Statements

molecular function
cell component
biological process
cellular response to DNA damage stimulus
determination method or standard
IGI
IEA
IMP
5 references
retrieved
14 February 2019
stated in
MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IGI
retrieved
14 February 2019
stated in
Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IGI
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JK91
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IEA
DNA mismatch repair
determination method or standard
IDA
IEA
IMP
ISO
16 references
retrieved
16 July 2018
stated in
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
ISO
retrieved
16 July 2018
stated in
Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
ISO
retrieved
16 July 2018
stated in
Meiotic pachytene arrest in MLH1-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
16 July 2018
stated in
Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
16 July 2018
stated in
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
16 July 2018
stated in
Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
16 July 2018
stated in
Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
16 July 2018
stated in
Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
16 July 2018
stated in
A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
16 July 2018
stated in
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
16 July 2018
stated in
Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
16 July 2018
stated in
Different mutator phenotypes in Mlh1- versus Pms2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
16 July 2018
stated in
Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IEA
retrieved
16 July 2018
stated in
Efficient repair of A/C mismatches in mouse cells deficient in long-patch mismatch repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
determination method or standard
IDA
DNA mismatch repair
determination method or standard
IBA
IDA
IEA
IMP
ISO
17 references
retrieved
14 February 2019
stated in
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
ISO
retrieved
14 February 2019
stated in
Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
ISO
retrieved
14 February 2019
stated in
Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
Different mutator phenotypes in Mlh1- versus Pms2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
Meiotic pachytene arrest in MLH1-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IMP
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IEA
retrieved
14 February 2019
stated in
Efficient repair of A/C mismatches in mouse cells deficient in long-patch mismatch repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
determination method or standard
IBA

Identifiers

 
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