Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (Q14887711)

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mammalian protein found in Mus musculus

Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
phosphoinositide-3-kinase catalytic alpha polypeptide
phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
serine/threonine protein kinase PIK3CA
PI3K-alpha
ptdIns-3-kinase subunit alpha
ptdIns-3-kinase subunit p110-alpha
2.7.11.1
PI3-kinase subunit alpha
p110alpha
PI3Kalpha
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Language	Label	Description	Also known as
English	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	mammalian protein found in Mus musculus	Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide phosphoinositide-3-kinase catalytic alpha polypeptide phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha serine/threonine protein kinase PIK3CA PI3K-alpha ptdIns-3-kinase subunit alpha ptdIns-3-kinase subunit p110-alpha 2.7.11.1 PI3-kinase subunit alpha p110alpha PI3Kalpha phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Statements

1 reference

25 May 2022

UniProt protein ID

Phosphatidylinositol 3-kinase, Vps34 type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

Phosphatidylinositol kinase family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

Armadillo-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol 3-kinase, C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PI3Kalpha, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphoinositide 3-kinase, accessory (PIK) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

nucleotide binding

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

1-phosphatidylinositol-3-kinase activity

determination method or standard

4 references

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

determination method or standard

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

determination method or standard

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

determination method or standard

16 July 2018

Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

determination method or standard

protein kinase activator activity

determination method or standard

1 reference

9 May 2019

Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

1-phosphatidylinositol-4-phosphate 3-kinase activity

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

protein serine/threonine kinase activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

protein binding

determination method or standard

5 references

9 May 2019

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Bioinformatics and cellular signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

insulin receptor substrate binding

determination method or standard

1 reference

9 May 2019

Involvement of tissue plasminogen activator in onset and effector phases of experimental allergic encephalomyelitis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

kinase activity

determination method or standard

4 references

9 May 2019

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

phosphatidylinositol 3-kinase activity

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

determination method or standard

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

1-phosphatidylinositol-3-kinase activity

determination method or standard

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

phosphatidylinositol-3,4-bisphosphate 5-kinase activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

plasma membrane

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

determination method or standard

1 reference

9 May 2019

Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

phosphatidylinositol 3-kinase complex, class IA

determination method or standard

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

phosphatidylinositol 3-kinase complex

determination method or standard

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

biological process

negative regulation of neuron apoptotic process

determination method or standard

1 reference

9 May 2019

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

protein kinase B signaling

determination method or standard

1 reference

9 May 2019

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

regulation of multicellular organism growth

determination method or standard

1 reference

9 May 2019

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

hypomethylation of CpG island

determination method or standard

1 reference

9 May 2019

Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

positive regulation of peptidyl-serine phosphorylation

determination method or standard

1 reference

9 May 2019

Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

protein phosphorylation

determination method or standard

1 reference

16 July 2018

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

glucose metabolic process

determination method or standard

1 reference

9 May 2019

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

energy homeostasis

determination method or standard

1 reference

9 May 2019

Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

regulation of gene expression

determination method or standard

1 reference

9 May 2019

Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

negative regulation of fibroblast apoptotic process

determination method or standard

1 reference

9 May 2019

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

liver development

determination method or standard

1 reference

9 May 2019

Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

adipose tissue development

determination method or standard

1 reference

9 May 2019

Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

regulation of cellular respiration

determination method or standard

1 reference

9 May 2019

Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

regulation of genetic imprinting

determination method or standard

1 reference

9 May 2019

Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

cellular response to glucose stimulus

determination method or standard

1 reference

9 May 2019

Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

phosphatidylinositol-mediated signaling

determination method or standard

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

determination method or standard

phosphatidylinositol-3-phosphate biosynthetic process

determination method or standard

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

determination method or standard

activation of protein kinase activity

determination method or standard

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

phosphorylation

determination method or standard

3 references

9 May 2019

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

adaptive immune response

determination method or standard

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

determination method or standard

inflammatory response

determination method or standard

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

determination method or standard

platelet activation

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

innate immune response

determination method or standard

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

determination method or standard

cell chemotaxis

determination method or standard

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

determination method or standard

positive regulation of smooth muscle cell proliferation

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

negative regulation of gene expression

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

protein phosphorylation

determination method or standard

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

phosphatidylinositol-3-phosphate biosynthetic process

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

phosphatidylinositol phosphate biosynthetic process

determination method or standard

regulation of protein phosphorylation

determination method or standard

1 reference

9 May 2019

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

protein phosphorylation

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

protein phosphorylation

determination method or standard

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

determination method or standard

Phosphatidylinositol 3-kinase, C2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

Phosphoinositide 3-kinase, accessory (PIK) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

PI3Kalpha, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42337

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000029201

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000029201

ENSMUSP00000103878

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000103878

ENSMUSP00000103877

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000103877

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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