DExD/H-box helicase 58 (Q21100537)

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mammalian protein found in Homo sapiens
  • antiviral innate immune response receptor RIG-I
  • RIG-I
  • RIG-I-like receptor 1
  • RNA helicase RIG-I
  • DEAD box protein 58
  • retinoic acid-inducible gene 1 protein
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
  • probable ATP-dependent RNA helicase DDX58
  • DDX58
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide
  • RLR-1
  • RIG-1
  • retinoic acid-inducible gene I protein
edit
Language Label Description Also known as
English
DExD/H-box helicase 58
mammalian protein found in Homo sapiens
  • antiviral innate immune response receptor RIG-I
  • RIG-I
  • RIG-I-like receptor 1
  • RNA helicase RIG-I
  • DEAD box protein 58
  • retinoic acid-inducible gene 1 protein
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
  • probable ATP-dependent RNA helicase DDX58
  • DDX58
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide
  • RLR-1
  • RIG-1
  • retinoic acid-inducible gene I protein

Statements

molecular function
protein binding
determination method or standard
IPI
33 references
retrieved
1 January 2018
stated in
DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
The nucleolar protein GLTSCR2 is required for efficient viral replication
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene I
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
The nucleolar protein GLTSCR2 is required for efficient viral replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Toscana virus NSs protein inhibits the induction of type I interferon by interacting with RIG-I
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
retrieved
1 January 2018
stated in
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IPI
cell component
biological process
positive regulation of interferon-beta production
determination method or standard
IDA
IEA
IMP
5 references
retrieved
1 January 2018
stated in
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IMP
retrieved
1 January 2018
stated in
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IMP
retrieved
1 January 2018
stated in
Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2
GOA
curator
UniProt
UniProt protein ID
O95786
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IMP
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IEA
retrieved
1 January 2018
stated in
Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786
determination method or standard
IDA

Identifiers

MeSH descriptor ID
D000071457
subject named as
DEAD Box Protein 58
0 references
Freebase ID
/m/03cx28s
0 references
PDB structure ID
 
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