Complement C5a receptor 1 (Q5008266)

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mammalian protein found in Homo sapiens

C5a anaphylatoxin chemotactic receptor 1
C5a anaphylatoxin receptor
C5a-R
C5aR
C5a anaphylatoxin chemotactic receptor
C5AR1
C5a ligand
complement component 5a receptor 1
complement component 5 receptor 1

Language	Label	Description	Also known as
English	Complement C5a receptor 1	mammalian protein found in Homo sapiens	C5a anaphylatoxin chemotactic receptor 1 C5a anaphylatoxin receptor C5a-R C5aR C5a anaphylatoxin chemotactic receptor C5AR1 C5a ligand complement component 5a receptor 1 complement component 5 receptor 1

Statements

1 reference

13 November 2019

UniProt protein ID

C5a1/C5a2 anaphylatoxin chemotactic receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21730

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

complement component C5a binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

signal transducer activity

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21730&geneProductId=UniProtKB:P21730

determination method or standard

complement receptor activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

complement component C5a receptor activity

determination method or standard

5 references

24 April 2018

rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21730&geneProductId=UniProtKB:P21730

determination method or standard

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21730&geneProductId=UniProtKB:P21730

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21730&geneProductId=UniProtKB:P21730

determination method or standard

24 April 2018

Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21730&geneProductId=UniProtKB:P21730

determination method or standard

24 April 2018

Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21730&geneProductId=UniProtKB:P21730

determination method or standard

G protein-coupled receptor activity

determination method or standard

4 references

8 April 2019

Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

complement component C5a receptor activity

determination method or standard

6 references

8 April 2019

rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

plasma membrane

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

apical part of cell

determination method or standard

1 reference

8 April 2019

Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

8 April 2019

Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

basolateral plasma membrane

determination method or standard

1 reference

8 April 2019

Novel insights in localization and expression levels of C5aR and C5L2 under native and post-transplant conditions in the kidney

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

cytoplasmic vesicle

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

secretory granule membrane

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

biological process

negative regulation of neuron apoptotic process

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

positive regulation of epithelial cell proliferation

determination method or standard

1 reference

8 April 2019

Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

mRNA transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

activation of phospholipase C activity

determination method or standard

1 reference

8 April 2019

Mitogen-activated Protein Kinase Activation Requires Two Signal Inputs from the Human Anaphylatoxin C5a Receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

neutrophil chemotaxis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

positive regulation of angiogenesis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

determination method or standard

3 references

8 April 2019

rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

cellular defense response

determination method or standard

1 reference

8 April 2019

The C5a chemoattractant receptor mediates mucosal defence to infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

response to lipopolysaccharide

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

animal organ regeneration

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

immune response

determination method or standard

1 reference

8 April 2019

Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

response to peptidoglycan

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

positive regulation of ERK1 and ERK2 cascade

determination method or standard

1 reference

8 April 2019

Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

positive regulation of neutrophil chemotaxis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

complement receptor mediated signaling pathway

determination method or standard

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21730&geneProductId=UniProtKB:P21730

determination method or standard

sensory perception of chemical stimulus

determination method or standard

1 reference

8 April 2019

Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

positive regulation of vascular endothelial growth factor production

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

cell proliferation in hindbrain

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

positive regulation of macrophage chemotaxis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

signal transduction

determination method or standard

3 references

8 April 2019

Molecular cloning and characterization of the human anaphylatoxin C3a receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

defense response to Gram-positive bacterium

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

apoptotic process

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

regulation of complement activation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

phospholipase C-activating G protein-coupled receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

neutrophil degranulation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

leukocyte migration

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21730&geneProductId=UniProtKB:P21730

determination method or standard

cell chemotaxis

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21730&geneProductId=UniProtKB:P21730

determination method or standard

positive regulation of cytosolic calcium ion concentration

determination method or standard

3 references

8 April 2019

Molecular cloning and characterization of the human anaphylatoxin C3a receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

G protein-coupled receptor signaling pathway

determination method or standard

complement component C5a signaling pathway

determination method or standard

1 reference

8 April 2019

Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

complement receptor mediated signaling pathway

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21730

determination method or standard

Gene Atlas image

PBB GE C5AR1 220088 at fs.png
732 × 530; 8 KB

0 references

http://purl.uniprot.org/uniprot/P21730

1 reference

Identifiers.org

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21730

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000347197

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000347197

ENSP00000470613

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470613

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(7 entries)

dewiki CD88
enwiki C5a receptor
ruwiki C5AR1
shwiki C5a receptor
srwiki C5a receptor
ukwiki C5AR1
zhwiki C5a受体

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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