eplerenone (Q423804)

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steroidal antimineralocorticoid of the spirolactone group that is used as an adjunct in the management of chronic heart failure

Language	Label	Description	Also known as
English	eplerenone	steroidal antimineralocorticoid of the spirolactone group that is used as an adjunct in the management of chronic heart failure

Statements

type of chemical entity

0 references

1 reference

based on heuristic

inferred from InChIKey

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chemical structure

Eplerenon.svg
352 × 242; 21 KB

1 reference

imported from Wikimedia project

German Wikipedia

414.204239±0 dalton

1 reference

language of work or name

Epoxymexrenone (English)

21 September 2016

chemical formula

C₂₄H₃₀O₆

1 reference

language of work or name

Epoxymexrenone (English)

21 September 2016

canonical SMILES

CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC

1 reference

19 February 2019

Eplerenone (English)

isomeric SMILES

COC(=O)[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@@]34O[C@@H]3C[C@@]5(C)[C@@H](CC[C@@]56CCC(=O)O6)[C@H]14

1 reference

Global Substance Registration System

15 February 2018

C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@]24[C@H](O4)C[C@]5([C@H]3CC[C@@]56CCC(=O)O6)C)C(=O)OC

1 reference

19 February 2019

Eplerenone (English)

defined daily dose

50 milligram

route of administration

oral administration

1 reference

https://www.whocc.no/atc_ddd_index/?code=C03DA04

active ingredient in

1 reference

15 February 2018

medical condition treated

arterial hypertension

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Drug Indications Extracted from FAERS

2 October 2018

significant drug interaction

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

(RS)-fenoprofen

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

(+-)-flurbiprofen

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

(RS)-ketoprofen

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

lisinopril dihydrate

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

(RS)-fenoprofen

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

(+-)-flurbiprofen

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

(RS)-ketoprofen

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

lisinopril dihydrate

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

(RS)-fenoprofen

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

(+-)-flurbiprofen

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

(RS)-ketoprofen

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

acute kidney injury

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

increased blood creatinine

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

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sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

legal status (medicine)

1 reference

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

pregnancy category

Australian pregnancy category B3

1 reference

imported from Wikimedia project

English Wikipedia

US pregnancy category B

1 reference

imported from Wikimedia project

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category E*

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Eplerenone

2 October 2017

subject has role

antimineralocorticoid

1 reference

Medical Subject Headings

MeSH descriptor ID

15 March 2018

NCI Thesaurus ID

C47513

1 reference

Global Substance Registration System

15 February 2018

Commons category

Eplerenone

0 references

Identifiers

InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

1 reference

19 February 2019

Eplerenone (English)

JUKPWJGBANNWMW-VWBFHTRKSA-N

2 references

Global Substance Registration System

15 February 2018

19 February 2019

Eplerenone (English)

CAS Registry Number

2 references

Global Substance Registration System

15 February 2018

JUKPWJGBANNWMW-VWBFHTRKSA-N

CAS Common Chemistry

9 April 2021

https://commonchemistry.cas.org/detail?cas_rn=107724-20-9

1 reference

language of work or name

Methyl (4aS,4bR,6aS,7R,9aS,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate (English)

21 September 2016

2 references

19 February 2019

Eplerenone (English)

matched by identifier from

JUKPWJGBANNWMW-VWBFHTRKSA-N

mapping relation type

2 references

ChEBI release 2021-03-01

matched by identifier from

International Chemical Identifier

InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

8 February 2021

2 references

based on heuristic

inferred from InChIKey

matched by identifier from

JUKPWJGBANNWMW-VWBFHTRKSA-N

UniChem compound ID

1 reference

1 reference

Hazardous Substances Data Bank

publication date

28 October 2019

EPLERENONE (English)

10 May 2021

DSSTox substance ID

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

matched by identifier from

JUKPWJGBANNWMW-VWBFHTRKSA-N

DSSTOX compound identifier

0 references

0 references

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

27 December 2018

Methyl (4aS,5aR,6aS,7S,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'Hspiro[cyclopenta[1,2]phenanthro[4,4ab]oxirene-7,2'-furan]-10-carboxylate (English)

CAS no.: 107724-20-9 (English)

ECHA Substance Infocard ID

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

27 December 2018

Methyl (4aS,5aR,6aS,7S,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'Hspiro[cyclopenta[1,2]phenanthro[4,4ab]oxirene-7,2'-furan]-10-carboxylate (English)

CAS no.: 107724-20-9 (English)

0 references

Guide to Pharmacology Ligand ID

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

5 February 2021

MeSH descriptor ID

subject named as

Eplerenone

0 references

0 references

D04.210.500.745.745.329

0 references

1 reference

Global Substance Registration System

15 February 2018

1 reference

matched by identifier from

JUKPWJGBANNWMW-VWBFHTRKSA-N

Human Metabolome Database ID

2 references

based on heuristic

inferred from InChIKey

matched by identifier from

JUKPWJGBANNWMW-VWBFHTRKSA-N

2 references

Global Substance Registration System

15 February 2018

matched by identifier from

JUKPWJGBANNWMW-VWBFHTRKSA-N

MedlinePlus drug identifier

0 references

PatientsLikeMe treatment ID

0 references

1 reference

26 February 2018

Probes And Drugs ID

0 references

1 reference

1 reference

imported from Wikimedia project

Japanese Wikipedia

0 references

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

WikiProjectMed ID

0 references

Sitelinks

Wikipedia(17 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:Eplerenone

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