Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action (Q38818048)

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scientific article published on 21 November 2015

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English	Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action	scientific article published on 21 November 2015

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

6 September 2017

Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action (English)

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Europe PubMed Central

PMC publication ID

6 September 2017

dasatinib monohydrate

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based on heuristic

inferred from title

pancreatic adenocarcinoma

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based on heuristic

inferred from title

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based on heuristic

inferred from title

3

object named as

Dirk Rades

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Europe PubMed Central

PMC publication ID

6 September 2017

object named as

Frank Gieseler

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ORCID Public Data File 2021

author name string

Tobias Bartscht

1

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Europe PubMed Central

PMC publication ID

6 September 2017

Benjamin Rosien

2

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Europe PubMed Central

PMC publication ID

6 September 2017

Roland Kaufmann

4

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Europe PubMed Central

PMC publication ID

6 September 2017

Harald Biersack

5

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Europe PubMed Central

PMC publication ID

6 September 2017

Hendrik Lehnert

6

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Europe PubMed Central

PMC publication ID

6 September 2017

Hendrik Ungefroren

8

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Europe PubMed Central

PMC publication ID

6 September 2017

publication date

21 November 2015

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Europe PubMed Central

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6 September 2017

Molecular Cancer

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6 September 2017

14

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6 September 2017

199

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Europe PubMed Central

PMC publication ID

6 September 2017

describes a project that uses

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RTCA

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

The role of dasatinib in the management of chronic myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Transforming growth factor β signaling overcomes dasatinib resistance in lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Combination of dasatinib and gemcitabine reduces the ALDH1A1 expression and the proliferation of gemcitabine-resistant pancreatic cancer MIA PaCa-2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Phase II study of dasatinib (BMS-354825) in patients with metastatic adenocarcinoma of the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

A phase 1 study of gemcitabine combined with dasatinib in patients with advanced solid tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Retracted: Concomitant Targeting of EGF Receptor, TGF-beta and Src Points to a Novel Therapeutic Approach in Pancreatic Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Inhibition of TGFβ signaling and its implications in anticancer treatments.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Clonogenic assay: adherent cells

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9 September 2017

Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Dasatinib: An Anti-Tumour Agent via Src Inhibition

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9 September 2017

Targeting tyrosine kinases: a novel therapeutic strategy for systemic sclerosis

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9 September 2017

Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

The epithelial-mesenchymal transition generates cells with properties of stem cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Dasatinib: a new step in molecular target therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Clonogenic assay of cells in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Dynamic and label-free cell-based assays using the real-time cell electronic sensing system

1 reference

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9 September 2017

Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

Overriding imatinib resistance with a novel ABL kinase inhibitor

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9 September 2017

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

9 September 2017

The Src family kinase inhibitors PP2 and PP1 block TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

14 September 2017

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

14 September 2017

Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

14 September 2017

Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

14 September 2017

Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

14 September 2017

Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

14 September 2017

Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

25 September 2017

Differential roles of Src in transforming growth factor-ß regulation of growth arrest, epithelial-to-mesenchymal transition and cell migration in pancreatic ductal adenocarcinoma cells.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

31 August 2018

Inhibition of tyrosine kinase Src suppresses pancreatic cancer invasiveness

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

31 August 2018

Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654868

31 August 2018

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

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https://pubmed.ncbi.nlm.nih.gov/26588899

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3

1 reference

https://pubmed.ncbi.nlm.nih.gov/26588899

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/26588899

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of TGF-beta inhibitor is dependent on the microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/26588899

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The generation of programmable cells of monocytic origin involves partial repression of monocyte/macrophage markers and reactivation of pluripotency genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26588899

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12943-015-0468-0

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Europe PubMed Central

PMC publication ID

6 September 2017

Dimensions Publication ID

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PMC publication ID

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Europe PubMed Central

PMC publication ID

6 September 2017

PubMed publication ID

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Europe PubMed Central

PMC publication ID

6 September 2017

ResearchGate publication ID

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