The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity (Q38337743)

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Language	Label	Description	Also known as
English	The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 September 2017

The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity (English)

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Europe PubMed Central

PubMed publication ID

2 September 2017

author name string

Alexey Dementiev

1

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Maurice Petitou

2

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Jean-Marc Herbert

3

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Peter G W Gettins

4

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Europe PubMed Central

PubMed publication ID

2 September 2017

publication date

15 August 2004

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Europe PubMed Central

PubMed publication ID

2 September 2017

Nature Structural & Molecular Biology

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Europe PubMed Central

PubMed publication ID

2 September 2017

11

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Europe PubMed Central

PubMed publication ID

2 September 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

863-867

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Europe PubMed Central

PubMed publication ID

2 September 2017

Clinical use of low molecular weight heparins and heparinoids

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Serpin structure, mechanism, and function

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Mechanism of heparin activation of antithrombin: evidence for an induced-fit model of allosteric activation involving two interaction subsites

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Mechanism of heparin activation of antithrombin. Evidence for reactive center loop preinsertion with expulsion upon heparin binding

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Synthesis of thrombin-inhibiting heparin mimetics without side effects

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

The anticoagulant activation of antithrombin by heparin

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

The structure of a Michaelis serpin-protease complex

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Role of Leu99 of thrombin in determining the P2 specificity of serpins

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Importance of the P2 glycine of antithrombin in target proteinase specificity, heparin activation, and the efficiency of proteinase trapping as revealed by a P2 Gly --> Pro mutation.

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Biological implications of a 3 A structure of dimeric antithrombin

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

The structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence Chemical and13C nuclear-magnetic-resonance studies

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

The molecular-weight-dependence of the anti-coagulant activity of heparin

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Molecular mapping of the heparin-binding exosite of thrombin

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Reactivities of the S2 and S3 subsite residues of thrombin with the native and heparin-induced conformers of antithrombin

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Tryptophan 60-D in the B-insertion loop of thrombin modulates the thrombin-antithrombin reaction

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Role of arginine 132 and lysine 133 in heparin binding to and activation of antithrombin

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

A novel one-step purification of human α-thrombin after direct activation of crude prothrombin enriched from plasma

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

[26] Screening for heavy-atom derivatives and obtaining accurate isomorphous differences.

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

21 January 2018

Rational design of synthetic heparin analogues with tailor-made coagulation factor inhibitory activity

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

31 March 2020

Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

31 March 2020

Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

31 March 2020

Contribution of lysine 60f to S1' specificity of thrombin

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

31 March 2020

The role of Glu(192) in the allosteric control of the S(2)' and S(3)' subsites of thrombin

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

31 March 2020

Influence of Arginines 93, 97, and 101 of Thrombin to Its Functional Specificity

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

31 March 2020

Preparation and characterization of anhydrothrombin

1 reference

https://api.crossref.org/works/10.1038%2FNSMB810

31 March 2020

Identifiers

10.1038/NSMB810

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

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